Evaluation of carboplatin dosage based on 4-variable modification of diet in renal disease equation.

Abstract:

BACKGROUND:Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR). METHODS:We performed a retrospective analysis of carboplatin dosage in our institute. Calvert formula derived carboplatin dose using eGFR calculated from the MDRD equation was compared to estimated CrCl from the Cockcroft-Gault and Jelliffe equations. RESULTS:Ninety-two carboplatin treatment episodes were recorded. eGFR and CrCl correlated reasonably well with a correlation coefficient (r) of 0.88. The correlation was weakest at lower levels of serum creatinine. Correcting eGFR for body surface area resulted in a tighter correlation (r = 0.94). CONCLUSION:The MDRD derived eGFR is readily available and may prove very useful in calculating carboplatin dosage for patients with impaired renal function.

journal_name

Ir J Med Sci

authors

Barry A,O'Cearbhaill R,Griffin D,Donnellan P,Keane M,Grimes H

doi

10.1007/s11845-008-0250-z

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

301-7

issue

3

eissn

0021-1265

issn

1863-4362

journal_volume

178

pub_type

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