Abstract：
BACKGROUND:Programmed cell death, or apoptosis, is a distinct, managed form of cell death. It is fundamentally different from necrosis. It is a genetically controlled, energy-dependent method of cellular deletion without inflammation. In the cardiovascular system, apoptosis occurs as a primary and secondary event in disease pathogenesis. This review addresses our current understanding of the initiation, propagation and significance of apoptosis in the cardiovascular system, as well as assessing therapeutic potentials arising therefrom. METHODS:A Medline search was performed and relevant publications reviewed. Further articles were obtained from the references of these publications. RESULTS:and conclusions Apoptotic cell death is a key element in the pathogenesis and progression of ischaemia-reperfusion (IR) injury, cardiac failure, myocardial infarction, atherosclerosis, endothelial dysfunction and the clinical syndromes which these situations produce. Our increased understanding of the role of apoptosis in the pathogenesis of cardiovascular disease offers potential to develop new therapeutic strategies.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
McLaughlin R,Kelly CJ,Kay E,Bouchier-Hayes Ddoi
10.1007/BF03168827keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
132-40issue
2eissn
0021-1265issn
1863-4362journal_volume
170pub_type
杂志文章,评审abstract：BACKGROUND:Anal ulceration is uncommon. Patients are typically referred because of severe anal pain, bleeding, discharge, and ulceration. It is important to exclude anal carcinoma, and to consider more unusual causes. METHODS:A 74-year-old lady presented with severe anal pain and ulceration. This was subsequently note...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169175
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND:The magnitude of effects of lean mass and fat mass on bone health is controversial, and this study is a contribution to understand its effects on skeletal composition. AIM:We explored the relationship of body fat and muscle parameters with bone mineral density (BMD) and age and observed if it changed when m...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02177-8
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Secondary prevention therapies, such as angiotension converting enzyme (ACE) inhibitors, beta-blockers and statins, are known to reduce cardiovascular morbidity and mortality. OBJECTIVE:The aim of the study was to examine the prevalence of coronary heart disease (CHD) and the prescribing of secondary preven...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169139
更新日期：2005-07-01 00:00:00
abstract：:We describe a man who was diagnosed with non-small cell lung cancer following previous treatment for small cell lung cancer. He developed dyspnoea, paroxysmal nocturnal dyspnoea and orthopnoea. Trans-thoracic echocardiogram revealed a large mass within the right atrium. The patient proceeded to thoracotomy at which ti...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0240-1
更新日期：2011-06-01 00:00:00
abstract：:Analysis of the results of treatment of localised prostate cancer with radiation and surgery has identified patients who are at high risk of developing metastatic dissemination. High histologic grade, serum prostate specific antigen above 20 ng/ml, extension beyond the capsule of the prostate, and involvement of lymph...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02937924
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Hemoglobin (HB) and red cell distribution width (RDW) are known to be prognostic in many cancer types. The HB-RDW ratio (HRR) is a new biomarker that has been shown to be predictive in some cancer types. However, the prognostic significance of HRR in patients with gastric cancer (GC) is unknown. AIMS:In thi...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02153-x
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:One in eight paediatric primary care presentations is for a musculoskeletal (MSK) disorder. These patients are frequently referred to paediatric orthopaedic surgeons; however, up to 50% of referrals are for normal variants. This results in excessive wait-times and impedes access for urgent surgical cases. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-017-1611-2
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:There is extensive focus on the rising costs of healthcare. However, for patients undergoing cancer treatment, there are additional personal costs, which are poorly characterised. AIM:To qualify indirect costs during anti-cancer therapy in a designated Irish cancer centre. METHODS:An anonymous questionnair...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-016-1483-x
更新日期：2017-02-01 00:00:00
abstract：:Nasal intermittent positive pressure ventilation (NIPPV) represents a major advance in the management of respiratory failure. While its role in chronic respiratory failure is well documented, its use in acute respiratory failure is less well defined. We studied four patients with respiratory failure due to kyphoscolio...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02968110
更新日期：1995-01-01 00:00:00
abstract：:It has been suggested in the literature that an eight hour period of distal oesophageal monitoring is adequate for the diagnosis of reflux in symptomatic patients. The aim of this study was to investigate whether 3 hour intra-oesophageal pH-metry could be substituted for the eight hour test period without loss of sens...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02947641
更新日期：1991-02-01 00:00:00
abstract：INTRODUCTION:Prostate cancer cells can switch from an androgen-dependent state to an androgen-independent state after a continuous androgen ablation therapy. However, the molecular mechanisms underlying this switch are still unclear. Therefore, we explored the change in androgen receptor (AR)-related gene expression du...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0714-4
更新日期：2011-12-01 00:00:00
abstract：:Height, body weight, the thickness of triceps, biceps, subscapular and supra-iliac skinfolds and the six-minute run-walk test of aerobic endurance were measured on 1163 National school children between the ages of 7 and 13, who were attending rural or urban schools in counties Cork, Galway, Limerick, Mayo, Waterford a...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942167
更新日期：1993-09-01 00:00:00
abstract：INTRODUCTION:Optimal risk factor control is integral to managing patients with proven coronary heart disease (CHD+) and for those at risk of coronary heart disease (CHD-). The primary aim of the study was to assess the success rate of reaching lipid risk factor targets in a multiple risk factor clinic. METHODS:A retro...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-0954-6
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Sport-related concussion (SRC) is a potential issue within Gaelic Football. Therefore, it is essential that concussion management guidelines are adhered to. HYPOTHESIS/PURPOSE:The aim of this study is to determine if potential concussive events (PCEs) in the Gaelic Athletic Association (GAA) National Footba...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02390-5
更新日期：2020-09-30 00:00:00
abstract：BACKGROUND:There is no agreeing if rescue therapy can avoid short-term colectomy in patients treated for severe steroid-refractory ulcerative colitis. AIMS:The aim of our study was to identify predictors of response to infliximab and cyclosporine A. METHODS:In this cross-sectional study, 49 patients with severe ulcer...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1666-0
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Inadequate medical documentation has been associated with a higher rate of adverse events and may have medicolegal consequences. An accurate admission note is critical as it is frequently referred to during inpatient stay, particularly when the patient is acutely unwell and during handover of care. AIM:We s...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02475-1
更新日期：2021-01-19 00:00:00
abstract：BACKGROUND:Circumcision is one of the world's most common operations. Series describing a new technique involving the use of fibrin-based glue have become more apparent in the literature. Here we outline the first 100 such cases for 62 children and 38 adults in our practice describing complications and learning curve. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-010-0545-8
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:We describe a case report and technique for using an ultrasound scanner and a linear transducer to guide serratus posterior superior (SPS) muscle injection. A 43-year-old female presented with chronic pain centered under the right upper portion of her scapula impacting her activities of daily living. METH...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1336-z
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Rubella is caused by the rubella virus, a single-stranded RNA virus of the Togaviridae family. The most severe complications of rubella in adult women occur during pregnancy when infection can lead to miscarriage, stillbirth or congenital rubella syndrome. Antenatal rubella susceptibility screening is no lon...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-017-1722-9
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:While considerable changes are happening in primary care in Ireland and considerable potential exists in intelligence derived from practice-based data to inform these changes, relatively few large-scale general morbidity surveys have been published. AIMS:To examine the most common reasons why people attend ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-015-1367-5
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To describe the relationship between parents with gender identity disorder (GID) and their child(ren) as described by the parent and to understand how being a parent affects transitioning from one gender to the other. METHODS:Fourteen parents with GID underwent a semi-structured interview and completed the I...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1003-1
更新日期：2014-06-01 00:00:00
abstract：:In automobile accidents, the "seatbelt syndrome" (SBS) consists of a constellation of injuries, predominantly involving thoraco-lumbar vertebral fractures and intraabdominal organ injury. A recent amendment to Irish legislation has made the wearing of seatbelts mandatory for all rear seated passengers in an effort to ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/s11845-008-0215-2
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Little is known about the economic impact of diabetic foot ulceration in the Irish healthcare setting. AIM:Audit of diabetic foot ulcer admissions in St James's Hospital between April 2001 and March 2002. METHODS:Hospital charts were reviewed and costs were calculated on the length of patients' hospital st...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02914564
更新日期：2004-04-01 00:00:00
abstract：INTRODUCTION:The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy. METHODS:Four groups of C57/Bl6 mice received 14 Gy ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0389-2
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Increasing prevalence of overweight and obese children in developed countries poses a substantial threat to long-term health. One well-described factor is the amount of time spent watching television, with exposure to food advertising a known influence on food preferences and consumption patterns. AIMS:Foll...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1088-1
更新日期：2015-03-01 00:00:00
abstract：:Direct Antibiotic Sensitivity Testing (DST) is a rapid means of diagnosing urinary tract infection (UTI) and obtaining antibiotic sensitivity patterns of the infecting organisms. In this study 227 urine samples from general practice were analysed using this technique with those obtained using the standard laboratory m...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02937439
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:The management of patients with chronic pain is challenging. The aim of treatment is alleviation of symptoms in an attempt to increase functional capacity. Interventional procedures, such as chemical neurolysis are adopted when other techniques fail to provide adequate pain control. RESULTS:An 82-year-old m...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0312-x
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Medication discrepancies at the time of hospital discharge are common and can result in error, patient/carer inconvenience or patient harm. Providing accurate medication information to the next care provider is necessary to prevent adverse events. AIMS:To investigate the quality and consistency of medicatio...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0142-2
更新日期：2008-06-01 00:00:00
abstract：:A bioassay method for measuring parathyroid hormone (PTH) and other substances that influence bone metabolism is described. Monolayers of bone cells are culturedin vitro, then treated with the test material. Biological activity is determined by measuring the resulting rise in bone-cell adenosine 3',5'-monophosphate (c...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02938966
更新日期：1976-12-01 00:00:00
abstract：BACKGROUND:The clinical spectrum of adult coeliac disease (ACD) is varied with limited Irish data. AIMS AND OBJECTIVES:The aim of this study was to analyse the presenting symptoms, associated conditions and complications in a consecutive series of patients with ACD. METHODS:Data were obtained from database on patient...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0788-z
更新日期：2012-06-01 00:00:00
