当前位置： SCI文献检索 > IRISH JOURNAL OF MEDICAL SCIENCE期刊下所有文献 > A retrospective study (2001-2017) of acute and chronic morbidity and mortality associated with Staphylococcus aureus bacteraemia in a tertiary neonatal intensive care unit.

A retrospective study (2001-2017) of acute and chronic morbidity and mortality associated with Staphylococcus aureus bacteraemia in a tertiary neonatal intensive care unit.

Abstract：

BACKGROUND:Staphylococcus aureus bacteraemia (SAB) in NICU patients can cause significant morbidity and mortality. AIMS:To review early and late neonatal SAB with regard to risk factors, treatment, acute complications and long-term outcomes. METHODS:A retrospective study of laboratory confirmed SAB over a 16-year period (November 2001-January 2017) in a tertiary neonatal unit in Ireland. FINDINGS:A total of 74 neonates (MSSA n = 72, MRSA n = 2) were identified; 8.1% (n = 6) early sepsis, 91.8% (n = 68) late sepsis. Low birth weight neonates (born weighing less than 2500 g) 80% (n = 59). Median age to bacteraemia 11 days post-delivery (range = 0-100 days); median onset early sepsis 1.5 days versus late sepsis 12 days. Complications of SAB; cellulitis n = 17, pneumonia n = 12, necrotising enterocolitis n = 7, thromobophlebitis n = 5, skin abscess formation n = 4, osteomyelitis n = 3, endocarditis n = 1. Late SAB mortality 6.4% (n = 3). CONCLUSIONS:Preterm and low birth weight infants were at highest risk of SAB. Only a small proportion of affected children had long-term clinical sequelae on follow-up. The high rate of recurrence and breakthrough bacteraemia suggests that early implementation of a targeted anti-staphylococcal antimicrobial regimen may be of particular benefit.

journal_name

Ir J Med Sci

journal_title

Irish journal of medical science

authors

O'Reilly D,O'Connor C,McCallion N,Drew RJ

doi

10.1007/s11845-019-01992-y

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1297-1301

issue

4

eissn

0021-1265

issn

1863-4362

pii

10.1007/s11845-019-01992-y

journal_volume

188

pub_type

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