Abstract:
BACKGROUND:The aim of this study was to investigate whether hypersplenism is related to the age of onset of liver disease. METHODS:Hypersplenism was assessed in 84 consecutive cirrhotic patients attending a university hospital liver clinic. RESULTS:Hypersplenism was present in 78% of patients and severe in 39%. Severe hypersplenism was more common in patients with cystic fibrosis liver disease (88%, P < 0.0001) and autoimmune hepatitis (60%, P = 0.0006) compared to alcoholic cirrhosis (12%). There was a significant correlation between patient age and platelet count r = 0.525, P < 0.0001 in the group as a whole and for the sub-group of patients with autoimmune hepatitis r = 0.54, P = 0.047. There was a negative correlation between age and spleen size r = -0.611, P < 0.0001. CONCLUSION:Younger patients had lower platelet counts, larger spleens and a higher incidence of hypersplenism suggesting that hypersplenism is significantly related to the age of onset of chronic liver disease.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
McCormick PA,Walker S,Benepal Rdoi
10.1007/s11845-007-0089-8subject
Has Abstractpub_date
2007-12-01 00:00:00pages
293-6issue
4eissn
0021-1265issn
1863-4362journal_volume
176pub_type
杂志文章abstract:BACKGROUND:Laparoscopic techniques are increasingly used in common surgical procedures. Many of these procedures are used to teach basic surgical trainees (BST) and therefore introduction of these techniques may have implications for training. AIMS:To establish whether the introduction of laparoscopic techniques reduc...
journal_title:Irish journal of medical science
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pub_type: 传,历史文章,杂志文章
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