Hypersplenism is related to age of onset of liver disease.

Abstract:

BACKGROUND:The aim of this study was to investigate whether hypersplenism is related to the age of onset of liver disease. METHODS:Hypersplenism was assessed in 84 consecutive cirrhotic patients attending a university hospital liver clinic. RESULTS:Hypersplenism was present in 78% of patients and severe in 39%. Severe hypersplenism was more common in patients with cystic fibrosis liver disease (88%, P < 0.0001) and autoimmune hepatitis (60%, P = 0.0006) compared to alcoholic cirrhosis (12%). There was a significant correlation between patient age and platelet count r = 0.525, P < 0.0001 in the group as a whole and for the sub-group of patients with autoimmune hepatitis r = 0.54, P = 0.047. There was a negative correlation between age and spleen size r = -0.611, P < 0.0001. CONCLUSION:Younger patients had lower platelet counts, larger spleens and a higher incidence of hypersplenism suggesting that hypersplenism is significantly related to the age of onset of chronic liver disease.

journal_name

Ir J Med Sci

authors

McCormick PA,Walker S,Benepal R

doi

10.1007/s11845-007-0089-8

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

293-6

issue

4

eissn

0021-1265

issn

1863-4362

journal_volume

176

pub_type

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