Abstract：
:1. Constrictor responses of the isolated perfused rabbit ear artery to electrical stimulation and to intraluminally applied noradrenaline and histamine have been studied before and after addition to the perfusate of the anticholinesterases neostigmine and physostigmine. 2. Both neostigmine (6×10(-5)-2.4×10(-4) mol/l) and physostigmine (6×10(-5)mol/l) caused a small but significant (P<0.05) increase in responses to electrical stimulation and to intraluminal noradrenaline and histamine. The degree of potentiation was similar for all three modes of stimulation, suggesting that neostigmine and physostigmine act at smooth muscle level rather than at nerve terminal level. 3. In the presence of a high potassium perfusate, the artery failed to respond to electrical stimulation but still responded to noradrenaline and histamine. In this medium, the potentiating action of neostigmine disappeared, suggesting that this action depends on the initial presence of a normal resting membrane potential in the arterial smooth muscle cells. 4. These results do not support the cholinergic link hypothesis, that acetylcholine is involved in the release of noradrenaline at adrenergic nerve terminals.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Wallace WF,Hobbs FM,Mock GRdoi
10.1007/BF02939056subject
Has Abstractpub_date
1975-12-01 00:00:00pages
469issue
1eissn
0021-1265issn
1863-4362pii
10.1007/BF02939056journal_volume
144pub_type
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