Abstract:
:The development of the Free Cortisol Index, an indirect measurement of the free or metabolically active portion of circulating cortisol, is described. Patients with non-adrenal disease had FCl values in the same range as normal subjects and in patients with adrenal disease the FCl values moved in the same direction as the total plasma cortisol. FCl values exhibited the same diurnal variation and response to ACTH as did total plasma cortisol in normal subjects. In pregnancy a significant rise in FCl was found confirming previous evidence of a degree of hyperadrenocorticalism in this condition.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Brien TG,Hingerty DJdoi
10.1007/BF02939036subject
Has Abstractpub_date
1975-12-01 00:00:00pages
343issue
1eissn
0021-1265issn
1863-4362pii
10.1007/BF02939036journal_volume
144pub_type
杂志文章abstract:BACKGROUND:The magnitude of effects of lean mass and fat mass on bone health is controversial, and this study is a contribution to understand its effects on skeletal composition. AIM:We explored the relationship of body fat and muscle parameters with bone mineral density (BMD) and age and observed if it changed when m...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02177-8
更新日期:2020-08-01 00:00:00
abstract:AIM:To examine the role of alcohol and alcohol-related cognitive impairment in the clinical presentation of adults in-patients less than 65 years who are 'hard to discharge' in a general hospital. METHOD:Retrospective medical file review of inpatients in CUH referred to the discharge coordinator between March and Sept...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0135-1
更新日期:2008-06-01 00:00:00
abstract::Ossifying fibromyxoid tumour of soft parts (OFMT) is a recently described soft tissue tumour. Although rare it deserves recognition as a locally invasive but essentially benign neoplasm. Prior to its description in 1989 by Enzinger, ossifying fibromyxoid tumours of soft parts were classified as a wide variety of lesio...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943588
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Cancellation of operations increases theatre costs and decreases efficiency. We examined the causes of theatre cancellations in general surgery. METHODS:The Beaumont hospital database (ORSUS system) and theatre records were examined retrospectively between April 1997 and March 2002. The number and causes of...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167925
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:In the last decades, the studies performed on the field of endothelial dysfunction confirmed the fact that the starting point of this pathology is the inflammation. Several inflammatory biomarkers had been discovered and studied, ones showing systemic inflammation, and others being more specific biomarkers a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1580-5
更新日期:2017-08-01 00:00:00
abstract::We identified 51 patients from pathology and operative records who were treated in the Royal Victoria Eye and Ear Hospital with malignant sinonasal tumours between January 1980 and December 1991. Complete follow up was available in 43 patients. There were 30 males, mean age 50 years, range (10-80) and 13 females, mean...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02973281
更新日期:1995-04-01 00:00:00
abstract:INTRODUCTION AND AIM:Various techniques have been proposed for the repair of abdominal wall defects (AWD) with varying rates of success. Despite the development of new materials and modifications of surgical technique, no single approach has emerged as the optimum way to close large AWD. We report a method for repairin...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0776-3
更新日期:2012-06-01 00:00:00
abstract:AIMS:To evaluate the potential role of key DNA repair proteins in the sensitivity of normal human fibroblasts to ionising radiations. METHODS:Radiosensitivity of six human fibroblast strains established from skin biopsies of women who had undergone conservative breast surgery and received a curative breast conserving ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-010-0554-7
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Assessment of non-cardiac chest pain places a considerable burden on healthcare resources. The current practice of serial electrocardiographs (ECGs), serum creatinine phosphokinase and by pre-discharge exercise electrocardiography gives an average in-hospital stay of 3.7 days. AIMS:This study assess the use...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03167689
更新日期:2000-07-01 00:00:00
abstract:INTRODUCTION:Pituitary tuberculosis is an uncommon cause of sellar mass [1]; the estimated prevalence worldwide is not known, and there have been no reports of the condition occurring in Ireland. Tuberculosis of the pituitary gland may present as a sellar mass or with symptoms of hypopituitarism. CASE PRESENTATION:A 4...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-017-1654-4
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:In recent decades the management of acute appendicitis has evolved significantly. Improved access to early imaging and better clinical scoring algorithms have resulted in less negative appendicectomy rates. In addition, non-operative management has become increasingly utilized. The aim of this study was to a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02349-6
更新日期:2020-08-27 00:00:00
abstract::The management of patients with suspected post laparotomy intra-abdominal sepsis poses a major therapeutic challenge to clinicians. The mortality is high and the optimal interventional modality remains ill-defined. We define the incidence, diagnostic methodology, pre- and postoperative findings and outcome of patients...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944195
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Recent developments in the management of severe aortic stenosis have resulted in a paradigm shift in the way we view the condition. Patients previously denied intervention in the form of surgical aortic valve replacement (SAVR) are now candidates for transcatheter aortic valve implantation and the risk and a...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-016-1417-7
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Coroners routinely enquire into suicide deaths and communicate with people bereaved by suicide. However, no research has been conducted into coroners' attitudes towards suicide and its prevention. AIMS:We assessed attitudes towards suicide among Irish coroners in order to determine their understanding of su...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0261-9
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The weight of the delivered placenta gives a useful representation of placental function in utero. In the absence of Irish data, many pathologists rely on data from other populations, many of which are now 15 to 30 years old. The development of a population-specific nomogram would aid in the examination of p...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-02102-8
更新日期:2020-05-01 00:00:00
abstract::Two-hundred and eleven Irish GPs responded to a questionnaire survey of their experience and management of acute myocardial infarction (MI) and their attitudes to the use of thrombolytic therapy Three-quarters of the respondents felt they dealt with three or more MIs per year; most felt that the majority of MIs were i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942365
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:With the increasing incidence of breast cancer in patients over 70 years, there is interest in the best therapeutic approach. AIMS:To review the management of breast cancer in elderly women and to identify the factors involved in the decision to treat patients with tamoxifen as first line therapy. PATIENTS...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168937
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The aims of this investigation was to analyse the response to second and third postal invitations from a group of patients previously invited for mammographic screening and to identify any demographic differences between responders and non-responders. SUBJECTS:The subjects were females aged 50-64 yr resident...
journal_title:Irish journal of medical science
pub_type: 临床试验,杂志文章
doi:10.1007/BF02939577
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Suicidal behaviour has become recognised as a major public health problem. AIM:To examine hospital-treated parasuicide and suicide in the Southern and Mid-Western Health Boards. METHODS:Parasuicide data were derived from independent data collection in general and psychiatric hospitals and prisons between 1...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02914492
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:Optimisation of patient comfort during flexible bronchoscopy is achieved with the use of intravenous sedation and vocal anaesthesia. METHODS:The effect of transcricoid lignocaine injection was investigated with regards to ease of procedure and frequency of cough. A single-blinded study was carried out and...
journal_title:Irish journal of medical science
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11845-014-1099-y
更新日期:2015-06-01 00:00:00
abstract::The bone marrow and peripheral blood findings of 22 selected patients with acute myeloid leukaemia were studied. A correlation was detected between the incidence of attainment of complete remission and the balance of nucleo-cytoplasmic differentiation in the neutrophil series. The prognostic significance of this findi...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02938916
更新日期:1976-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze neuropathic pain (NeP) and its therapy in patients with Guillain-Barré syndrome (GBS) during a 6-month follow-up period. METHOD:This longitudinal multicenter study included 69 newly diagnosed adult GBS patients. NeP diagnosis was based on the criteria of Finnerup and conf...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02395-0
更新日期:2020-10-15 00:00:00
abstract::More than 300 risk factors for coronary artery disease (CAD) have been described. There are important geographical and racial differences in both the prevalence of CAD and of potential risk factors. The purpose of this study was to determine the relationship between both the presence and extent of angiographically def...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943801
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Glycodelin plays an important role in normal and abnormal reproductive growth. The in vitro properties of glycodelin have been studied in K562 cells. The role of glycodelin in vivo in the peripheral circulation has not been determined. AIM:To determine if circulating leukocytes in normal subjects express th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0019-9
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Programmed cell death, or apoptosis, is a distinct, managed form of cell death. It is fundamentally different from necrosis. It is a genetically controlled, energy-dependent method of cellular deletion without inflammation. In the cardiovascular system, apoptosis occurs as a primary and secondary event in di...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/BF03168827
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Cadmium (Cd) is an environmental and industrial pollutant that induces a broad spectrum of toxicological effects, influences a variety of human organs, and is associated with poor semen quality and male infertility. Increasing evidence demonstrates that Cd induces testicular germ cell apoptosis in rodent ani...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1595-y
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Nearly half of the Irish population is covered by private health insurance. In recent years, premium inflation has been significantly ahead of overall inflation and has been accelerating. This has contributing to a drop in the numbers insured since the peak in 2008. The fall in the numbers with private healt...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-013-0929-7
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique po...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-01980-2
更新日期:2019-11-01 00:00:00
abstract::Quality of life of out-of-hospital cardiac arrest (OHCA) survivors is believed to be as important as a factor in resuscitation outcome as the survival rate. The aim of this investigation is to assess the quality of life outcomes of survivors of out-of- hospital cardiac arrest in the Munster region. OHCAR was used to i...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02189-4
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:There is extensive focus on the rising costs of healthcare. However, for patients undergoing cancer treatment, there are additional personal costs, which are poorly characterised. AIM:To qualify indirect costs during anti-cancer therapy in a designated Irish cancer centre. METHODS:An anonymous questionnair...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-016-1483-x
更新日期:2017-02-01 00:00:00