Abstract：
BACKGROUND:Cadmium (Cd) is an environmental and industrial pollutant that induces a broad spectrum of toxicological effects, influences a variety of human organs, and is associated with poor semen quality and male infertility. Increasing evidence demonstrates that Cd induces testicular germ cell apoptosis in rodent animals. However, the specific effect of Cd exposure on autophagy in germ cells is poorly understood. METHODS:We investigate the role of high-mobility group box 1 protein (HMGB1), a ubiquitous nuclear protein, on Cd-evoked autophagy in a mouse spermatocyte cell line (GC-2spd). RESULTS:Our data have shown that autophagy was significantly elevated in GC-2spd cells exposed to Cd. Furthermore, there was a reduction in rapamycin (RAP)-mediated apoptosis. In addition, Cd exposure reduced cell viability, which is an effect that could be significantly inhibited by RAP treatment. These results indicate that autophagy appears to serve a positive function in reducing Cd-induced cytotoxicity. In addition, HMGB1 increased coincident with the processing of LC3-I to LC3-II. Thus, the upregulation of HMGB1 increases LC3-II levels. CONCLUSIONS:Our data suggest that HMGB1-induced autophagy appears to act as a defense/survival mechanism against Cd cytotoxicity in GC-2spd cells.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Ou Z,Chen Y,Niu X,He W,Song B,Fan D,Sun Xdoi
10.1007/s11845-017-1595-ysubject
Has Abstractpub_date
2017-11-01 00:00:00pages
1041-1050issue
4eissn
0021-1265issn
1863-4362pii
10.1007/s11845-017-1595-yjournal_volume
186pub_type
杂志文章abstract：OBJECTIVE:To analyze the capability of four-dimensional surface rendering mode ultrasound (4D SRM USG) in the detection of fetal abnormalities, and also compare it with 2D USG. MATERIALS AND METHODS:A total of 1,379 pregnant women were enrolled in the study, and they all underwent 2D USG screening. In the same session...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-014-1184-2
更新日期：2015-09-01 00:00:00
abstract：INTRODUCTION:The medical elective is a common component of undergraduate medical education in the UK and Ireland. These are often undertaken in varied hospitals and countries across the world, most of which are not related to their parent institutions, in order to explore specialties and regions of interest. However ex...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1919-6
更新日期：2019-08-01 00:00:00
abstract：:A bioassay method for measuring parathyroid hormone (PTH) and other substances that influence bone metabolism is described. Monolayers of bone cells are culturedin vitro, then treated with the test material. Biological activity is determined by measuring the resulting rise in bone-cell adenosine 3',5'-monophosphate (c...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02938966
更新日期：1976-12-01 00:00:00
abstract：:RADIOACTIVE fallout from the Chernobyl accident reached Ireland in May 1986 and caused serious concern with regard to its possible effects on health. Reports of a large scale American study claim an almost immediate effect of Chernobyl fallout in terms of increased mortality rates. A study of Irish mortality rates rep...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02943039
更新日期：1989-05-01 00:00:00
abstract：:A ten year review (1980-1989) of 59 neonates presenting with congenital diaphragmatic hernia (CDH) to Our Lady's Hospital for Sick Children, the main referral centre for neonatal surgery in Ireland, is presented to determine the outcome and make suggestions for improvements. CDH was more common in males (34M, 25F). Th...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02984671
更新日期：1992-01-01 00:00:00
abstract：AIMS:A retrospective post-mortem analysis was undertaken to determine the aetiology of sudden cardiac death (SCD) amongst individuals aged journal_title：Irish journal of medical science pub_type： 杂志文章 doi：10.1007/s11845-009-0294-8 更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:The first Irish heart transplant was performed on the 10th of September 1985. Over the next 20 years, 229 transplants were performed in 228 recipients. AIMS:To evaluate the success of the first generation of cardiac transplantation in Ireland. METHODS:Analysis of clinical outcomes and survival statistics f...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03168991
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Osteoid osteoma is a painful benign bone tumour. Previously the standard therapy was surgical excision. Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner. AIMS:We present a case of an 18-year-old boy who presented with features of chronic left...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169159
更新日期：2005-07-01 00:00:00
abstract：:Self-instruction programmes comprise audio tapes and a variety of visual materials ranging from photographs to models. The use of such programmes in an anatomy course is described and illustrated. They are an effective ancillary in teaching and are applicable to other medical teaching disciplines. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02938052
更新日期：1979-12-01 00:00:00
abstract：:An unusual case of a well-documented granulomatous hepatitis in secondary syphilis in a 47-year-old male is presented. This hepatic pathology in secondary syphilis is summarised, and a review of the literature regarding syphilitic granulomatous hepatitis presented. ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,评审
doi：10.1007/BF02937251
更新日期：1990-02-01 00:00:00
abstract：OBJECTIVE:We describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide. DESIGN AND METHODS:To determine whether the patient might respond to therapeutic administr...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0171-x
更新日期：2008-09-01 00:00:00
abstract：:Two-hundred and eleven Irish GPs responded to a questionnaire survey of their experience and management of acute myocardial infarction (MI) and their attitudes to the use of thrombolytic therapy Three-quarters of the respondents felt they dealt with three or more MIs per year; most felt that the majority of MIs were i...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02942365
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND:Anaesthetists are at high risk from blood-borne pathogens. Universal Precautions (UP) include the routine use of appropriate barrier precautions and techniques to reduce the likelihood of exposure to blood, body fluids and tissues that may contain pathogens. The compliance of Irish anaesthetists with these p...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03167699
更新日期：2000-07-01 00:00:00
abstract：INTRODUCTION:Optimal risk factor control is integral to managing patients with proven coronary heart disease (CHD+) and for those at risk of coronary heart disease (CHD-). The primary aim of the study was to assess the success rate of reaching lipid risk factor targets in a multiple risk factor clinic. METHODS:A retro...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-0954-6
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:To review the clinical impact of vertebroplasty in osteoporotic and myelomatous compression fractures METHODS:Eleven compression fractures in eight patients were treated by percutaneous cement vertebroplasty over a three-year period, May 2000 to May 2003. RESULTS:Successful percutaneous stabilisation and c...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF03169001
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Cosmetic outcomes and scar lengths remain important considerations in breast cancer surgery. Suturing techniques should decrease scar tissue formation and provide good cosmetic results. The use of an accordion suturing technique may result in decreased surgical wound lengths and better cosmetic outcomes. We ...
journal_title：Irish journal of medical science
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11845-018-1772-7
更新日期：2018-11-01 00:00:00
abstract：:Mesenteric venous thrombosis, "the great mimicker", is a very rare disorder in pregnancy and the puerperium, particularly when not associated with any pre-existing thrombophilia or autoimmune states. We describe a patient requiring a resection of 150 cm of gangrenous small bowel after uncomplicated elective Caesarean ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02945845
更新日期：1999-07-01 00:00:00
abstract：:Isolated third cranial nerve palsy is usually due to vascular causes like posterior communicating artery aneurysm and it is rare in neurocysticercosis. Third cranial nerve palsy in neurocysticercosis is usually caused by supratentorial or sub-arachnoid lesions with accompanying hydrocephalus or meningitis. We report a...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-009-0308-6
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:Prostate cancer cells can switch from an androgen-dependent state to an androgen-independent state after a continuous androgen ablation therapy. However, the molecular mechanisms underlying this switch are still unclear. Therefore, we explored the change in androgen receptor (AR)-related gene expression du...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-011-0714-4
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Solitary adenomas have been shown to be responsible for almost 90% of cases of primary hyperparathyroidism. AIM:The purpose of this study was to determine the utility of sestamibi scanning pre-operatively to guide minimally invasive video-assisted (MIVA) parathyroidectomy. METHODS:We reviewed 40 patients w...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0075-1
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:The Factor V Leiden (FVL) mutation is the commonest genetic abnormality associated with venous thromboembolism. AIMS:To determine the prevalence of the FVL mutation in Irish patients undergoing total hip replacement and whether it has an increased risk of deep venous thrombosis or pulmonary embolism (DVT/PE...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-007-0095-x
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:A congenital diaphragmatic hernia (Bochdalek's hernia) rarely presents in adulthood. CASE PRESENTATION:We present the case of a 21-year-old woman with thrombocytopenia secondary to hypersplenism due to left-sided (sinistral) portal hypertension. This portal hypertension was caused by strangulation of the sp...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-008-0140-4
更新日期：2009-03-01 00:00:00
abstract：:The case of a 27 month old male with a congenital midline nasal dermoid cyst is presented. The child attended the Ear, Nose and Throat outpatient's department in July 1995, with an external midline nasal swelling, which had been present at birth and was noted to be gradually increasing in size. Magnetic resonance imag...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02943594
更新日期：1997-07-01 00:00:00
abstract：:1. Constrictor responses of the isolated perfused rabbit ear artery to electrical stimulation and to intraluminally applied noradrenaline and histamine have been studied before and after addition to the perfusate of the anticholinesterases neostigmine and physostigmine. 2. Both neostigmine (6×10(-5)-2.4×10(-4) mol/l) ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02939056
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:Inadequate medical documentation has been associated with a higher rate of adverse events and may have medicolegal consequences. An accurate admission note is critical as it is frequently referred to during inpatient stay, particularly when the patient is acutely unwell and during handover of care. AIM:We s...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-020-02475-1
更新日期：2021-01-19 00:00:00
abstract：BACKGROUND:Adults ageing with HIV and on antiretroviral therapy have a greater burden of chronic diseases compared with adults without HIV as reported by Althoff et al. (Curr Opin HIV AIDS 11:527-36, 2016). Therefore, it is important in this clinically stable HIV+ population to monitor and evaluate their risk of chroni...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-019-02063-y
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:The "National Integrated Medical Imaging System" or NIMIS went live in 2011 and allows the movement of patient radiology imaging throughout the Irish health system. At the time of its launch, NIMIS was not only going to allow the filmless passage of patient radiology imaging but it was also envisaged that ...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-018-1900-4
更新日期：2019-05-01 00:00:00
abstract：:Menorrhagia affects 20-30% of healthy women, many of whom undergo hysterectomy. In recent years, transcervical resection of the endometrium (TCRE) has become an alternative surgical option. This observational study assesses patient satisfaction following TCRE. The case notes of 55 patients who had a TCRE in the Coombe...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02940244
更新日期：1996-07-01 00:00:00
abstract：:STRIPS of bovine tracheal smooth muscle were subjected to changes in the gas tensions of the Krebs solution bathing them. Contractions were produced by 50 Hz sine-wave electrical field stimulation, either in single bursts, or repetitively throughout the experiment.Hypoxia (Po2 99, 55 or 22 mm Hg, pH 7.4) decreased the...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/BF02939006
更新日期：1975-12-01 00:00:00
abstract：BACKGROUND:Ankylosing spondylitis (AS) is characterised by insidious onset lower back pain. Poor symptom recognition results in delays in diagnosis of up to 11 years. Despite the widespread use of anti-tumour necrosis factor alpha (anti-TNFα) therapy, work disability remains a challenging problem in AS. METHODS:A retr...
journal_title：Irish journal of medical science
pub_type： 杂志文章
doi：10.1007/s11845-013-1054-3
更新日期：2014-12-01 00:00:00
