Abstract:
OBJECTIVE:To describe the incidence and obstetric and perinatal outcomes in primigravid Black South Africans with hypertensive disorders of pregnancy (HDP). METHOD:All primigravidae who booked for antenatal care were followed up until hospital discharge. Relevant clinical and demographic data were collected in structured data forms. RESULTS:A total of 5860 primigravidae delivered during the study period. Of these, 731 had an HDP, giving an incidence of 12.5%. The diagnosis of gestational hypertension was made in 6.7% of all primigravidae but was the commonest HDP subcategory (n = 394/731; 53.9%). On the other hand, mild to moderate preeclampsia or non-severe preeclampsia, severe preeclampsia, and eclampsia occurred in 222, 84, and 31 of the 5860 primigravidae, respectively. Therefore, preeclampsia-eclampsia syndrome occurred in 337/5860 or 5.75% of the study population. Severe preeclampsia occurred in 1.43% (84/5860) of the primigravidae. The rates of caesarean deliveries in women with preeclampsia were approximately 50%. There were no perinatal deaths in the gestational hypertension group, but the overall perinatal mortality rate in all preeclamptics was 5.9%, in comparison to 2.2% in all primigravidae. CONCLUSION:Hypertensive disorders of pregnancy developed in 12.5% (n = 731/5860) of primigravidae seen over a one-year period. Gestational hypertension comprised the commonest subcategory of the HDP and there were no perinatal deaths in this group.
journal_name
Hypertens Pregnancyjournal_title
Hypertension in pregnancyauthors
Moodley J,Onyangunga OA,Maharaj NRdoi
10.1080/10641955.2016.1193190subject
Has Abstractpub_date
2016-11-01 00:00:00pages
529-535issue
4eissn
1064-1955issn
1525-6065journal_volume
35pub_type
杂志文章abstract:OBJECTIVE:To report about a case of complicated late postpartum eclampsia where neonatal low birth weight could be considered a predictive factor of placental sufferance. METHODS:A 25-year-old woman, without medical or familiar history for hypertension or cerebrovascular diseases, underwent a normal spontaneous delive...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2010.506231
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To examine the management of early-onset preeclampsia and its maternal and fetal morbidity and mortality. DESIGN:Retrospective cohort study of 49,812 births at a university teaching hospital between June 1986 and March 1997. Seventy-one women were identified with a diagnosis of preeclampsia with an onset at ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/prg-100100138
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS:131 pregnant women cons...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,随机对照试验
doi:10.1080/10641955.2018.1446977
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Women with a history of preeclampsia have an increased risk of cardiovascular disease. Gynaecologists have an important role in the counselling and management of cardiovascular risk factors after preeclampsia. We aimed to assess the role of gynaecologists in informing women on interventions and risk factor fo...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1100311
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that the risk of preeclampsia in nulliparous women may be due to an anti-angiogenic state. METHODS:Maternal serum samples obtained in the third trimester from nulliparous (n = 86) and multiparous (n = 165) singleton uncomplicated pregnancies were analyzed for levels of angiogenic facto...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2013.858745
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To provide long-term follow-up data on women with a history of hemolysis, elevated liver enzymes, and low platelets [(H)ELLP] syndrome regarding the risk of recurrence in subsequent pregnancies and disease in later life. METHODS:All women admitted to the Academic Medical Centre between January 1984 and Janua...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-100104168
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. METHODS:The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802601187
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To compare connexin expression in omental resistance arteries from preeclamptic women and normal gravidas. METHODS:Small arteries (approximately 200-400 microm i.d.) were dissected from omental fat biopsies, taken at cesarean delivery from normotensive and preeclamptic women. Vessels were frozen and homogeni...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-100104178
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120004767
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Low-dose aspirin can reduce the incidence of preeclampsia and intrauterine growth restriction (IUGR). However, the effects of ethnicity upon low-dose aspirin's efficacy has not been analyzed. Here, we comparatively evaluated the efficacy of low-dose aspirin in preventing preeclampsia and related fetal compli...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,meta分析,评审
doi:10.1080/10641955.2016.1178772
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To determine whether Chlamydia pneumoniae antibodies and highly sensitive C-reactive protein (hsCRP) levels in maternal sera are associated with preeclampsia or gestational hypertension. METHODS:C. pneumoniae antibodies and hsCRP levels were measured in maternal serum during first trimester (mean, 10.4 weeks...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701885188
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the value of placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PLGF ratio, in predicting symptomatic preeclampsia (PE). METHODS:A prospective longitudinal study was carried out on 71 high risk preeclamptic women cohort. All of t...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2013.807818
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:We compared second pregnancy outcomes among women with and without preeclampsia in their first pregnancies who all had second pregnancies without preeclampsia. METHODS:One hundred thirty women with and 6148 without preeclampsia in their first pregnancies, who all had nonpreeclamptic second pregnancies, were...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-200059869
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to quantify adiponectin levels in women with normal and hypertensive pregnancies to determine whether there is an independent association, while controlling for body fat and insulin sensitivity. METHODS:A cross-sectional study was conducted in the following categories: 12 normotensi...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950600912976
更新日期:2006-01-01 00:00:00
abstract::The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1397690
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-200030860
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1117099
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Pre-eclampsia is associated with significant maternal and neonatal complications, and delivery is often expedited to minimise complications. For randomised trials evaluating interventions in women with late-onset (>34 weeks) mild to moderate pre-eclampsia, no single outcome has been identified to be the most ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2013.837176
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1242605
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS:Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS:The PE group had significantly lower apelin...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1777300
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To characterize the maternal and fetal presentation of abruptio placentae and associated maternal and fetal morbidity and mortality by mode of delivery and fetal status on admission. STUDY DESIGN:Perinatal data (gestational age > 24 weeks) from women with abruptio placentae at a tertiary referral center were...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-100106969
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:Oxidative stress and a generalized inflammatory state are features of preeclampsia (PE). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with PE, and to determine the relationship between oxidative stress and inflammation in P...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802233064
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). METHODS:In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase ch...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1250904
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:We examined serum concentrations of basic fibroblast growth factor (bFGF) in women with hypertensive disorders in pregnancy and analyzed whether serum concentrations of bFGF can be used as a discriminator between mild and severe preeclampsia. METHODS:One hundred and twenty pregnant women were included in thi...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120016790
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity. METHODS:Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography. RESULTS:Sodium nitroprusside-i...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10601330701274824
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To investigate the importance of prostacyclin and nitric oxide synthesis in endothelium-dependent relaxation in myometrial resistance vessels, and to test the hypothesis that a deficiency in nitric oxide synthesis contributes to the known alterations in endothelial function in preeclampsia. METHODS:Thirty-si...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641959909009611
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS:A prospective case-control study included a study group consisting of 30 pregnant women with p...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1212872
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. METHODS:Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,多中心研究
doi:10.3109/10641955.2011.640375
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Hypertension that develops after 20 gestational weeks and is defined as pregnancy-induced hypertension (PIH). The main cause of PIH is vasoconstriction and the thickening of vascular media, which decreases vascular capacity and increases peripheral resistance. One of the theories postulated to explain this p...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950600601835
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS:Microarray-based study was carried out with placental samples. RESULTS:Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however,...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,评审
doi:10.3109/10641955.2013.807819
更新日期:2013-11-01 00:00:00