Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia.

abstract：:Intracranial hemorrhage and stroke are primary causes of maternal mortality in pregnancies affected by hypertensive disorders. As such antihypertensive therapy plays a crucial role in the management of severe hypertension. However, the target level to achieve the best outcome for both - mother and fetus - is still unc...

journal_title：Hypertension in pregnancy

authors： Wertaschnigg D,Wang R,Reddy M,Costa FDS,Mol BWJ,Rolnik DL

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To examine the association between calcium levels during the first trimester of pregnancy and preeclampsia. METHODS:The study population included registered births (n = 5233) in a tertiary medical center between 2001 and 2011. A comparison was performed between women with and without hypocalcemia during the ...

journal_title：Hypertension in pregnancy

authors： Gabbay A,Tzur T,Weintraub AY,Shoham-Vardi I,Sergienko R,Sheiner E

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To report a case of cardiac arrhythmia related to a low dose of endovenous lanatoside C. CASE REPORT:A 23-year-old pregnant woman with mitral regurgitation complicated with preeclampsia and pulmonary edema presented 2 episodes of atrial tachycardia induced by a intravenous digitalis (2 mg, IV and 1 mg, IV, r...

journal_title：Hypertension in pregnancy

authors： Roscani MG,Zanati SG,Magalhães CG,Borges VT,Matsubara BB

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...

journal_title：Hypertension in pregnancy

authors： Namlı Kalem M,Kalem Z,Yüce T,Soylemez F

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:(i) To compare the levels of soluble Fas (sFas) in the sera of patients with variable degrees of preeclampsia and in healthy gravidas; and (ii) to correlate sFas with clinical, laboratory, and Doppler parameters in preeclampsia. METHODS:Fifty patients with mild preeclampsia, 50 patients with severe preeclam...

journal_title：Hypertension in pregnancy

authors： El-Sherbiny W,Soliman A,El-Mazny A

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). METHODS:In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase ch...

journal_title：Hypertension in pregnancy

authors： Karakus S,Bagci B,Bagci G,Sancakdar E,Yildiz C,Akkar O,Cetin A

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Chymase, a chymotrypsin-like protease, is a non-ACE angiotensin II (Ang II) generating enzyme. We determined if maternal chymotrypsin-like protease/chymase activity was increased in women with preeclampsia (PE). METHODS:Maternal plasma was extracted from venous blood of healthy nonpregnant women, women with ...

journal_title：Hypertension in pregnancy

authors： Wang Y,Gu Y,Lewis DF,Alexander JS,Granger DN

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To investigate the importance of prostacyclin and nitric oxide synthesis in endothelium-dependent relaxation in myometrial resistance vessels, and to test the hypothesis that a deficiency in nitric oxide synthesis contributes to the known alterations in endothelial function in preeclampsia. METHODS:Thirty-si...

journal_title：Hypertension in pregnancy

authors： Ashworth JR,Baker PN,Warren AY,Johnson IR

更新日期：1999-01-01 00:00:00

abstract：:The pathophysiology of preeclampsia (PET) implicates an inflammatory dysfunction. This study profiled this host response by challenging whole blood with lipopolysaccharide. Multiplex immunoassays determined interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12(p70), IL-13, IL-17, granulocyte/granulo...

journal_title：Hypertension in pregnancy

authors： Brewster JA,Orsi NM,Gopichandran N,Ekbote UV,Cadogan E,Walker JJ

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. METHODS:Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four...

journal_title：Hypertension in pregnancy

authors： Pecks U,Schütt A,Röwer C,Reimer T,Schmidt M,Preschany S,Stepan H,Rath W,Glocker MO

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hypertension that develops after 20 gestational weeks and is defined as pregnancy-induced hypertension (PIH). The main cause of PIH is vasoconstriction and the thickening of vascular media, which decreases vascular capacity and increases peripheral resistance. One of the theories postulated to explain this p...

journal_title：Hypertension in pregnancy

authors： Kwiatkowski S,Kwiatkowska E,Czajka R,Ciechanowski K,Kedzierska K,Bober J,Rzepka R,Golembiewska E,Chlubek D

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Oxidative stress and a generalized inflammatory state are features of preeclampsia (PE). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with PE, and to determine the relationship between oxidative stress and inflammation in P...

journal_title：Hypertension in pregnancy

authors： Ouyang YQ,Li SJ,Zhang Q,Cai HB,Chen HP

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...

journal_title：Hypertension in pregnancy

authors： Livingston JC,Ahokas R,Haddad B,Sibai BM,Awaads R

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). METHODS:A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and materna...

journal_title：Hypertension in pregnancy

authors： Christiansen M,Hedley PL,Placing S,Wøjdemann KR,Carlsen AL,Jørgensen JM,Gjerris AC,Shalmi AC,Rode L,Sundberg K,Tabor A

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...

journal_title：Hypertension in pregnancy

authors： Xuan J,Jing Z,Yuanfang Z,Xiaoju H,Pei L,Guiyin J,Yu Z

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To determine the correlation between simultaneous assessment of maternal middle cerebral blood flow velocity with the other maternal hemodynamic factors of cardiac output and mean arterial pressure. STUDY DESIGN:Eight normotensive patients were assessed. Maternal cerebral blood flow velocity was assessed usi...

journal_title：Hypertension in pregnancy

authors： Williams KP,Wilson S

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To identify parameters that may assist clinicians in predicting which women will develop preeclampsia (PE) after initially presenting with gestational hypertension (GH). METHODS:118 women were recruited to the study with GH or PE. They were divided into three groups based on their diagnosis at delivery- (1) ...

journal_title：Hypertension in pregnancy

authors： Davis GK,Mackenzie C,Brown MA,Homer CS,Holt J,McHugh L,Mangos G

更新日期：2007-01-01 00:00:00

abstract：:Preeclampsia and intrauterine growth restriction are both characterized by placental malfunction. The pathological processes of abnormal trophoblast invasion, partial absence of maternal spiral artery modification, increased apoptosis of trophoblast cells, and placental ischemia are all associated with the release of ...

journal_title：Hypertension in pregnancy

authors： Tjoa ML,Oudejans CB,van Vugt JM,Blankenstein MA,van Wijk IJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Case report of a 35-year-old gravida 3, para 2, at 40 + 6 weeks with massive respiratory dysfunction with need of oxygenation, requiring cesarean section. CASE REPORT:Postpartum investigations revealed pathological cardiomegaly with left ventricular failure (NYHAIV). Cardiac biopsy diagnosed postpartum dilat...

journal_title：Hypertension in pregnancy

authors： Freerksen N,Jaekel J,Menon AK,Maass N,Bauerschlag D

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...

journal_title：Hypertension in pregnancy

authors： Maymon R,Trahtenherts A,Svirsky R,Melcer Y,Madar-Shapiro L,Klog E,Meiri H,Cuckle H

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine. METHODS:Blood pressure and FHT categories were assessed one hour before and after medication administration. Hy...

journal_title：Hypertension in pregnancy

authors： Sharma KJ,Rodriguez M,Kilpatrick SJ,Greene N,Aghajanian P

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To provide long-term follow-up data on women with a history of hemolysis, elevated liver enzymes, and low platelets [(H)ELLP] syndrome regarding the risk of recurrence in subsequent pregnancies and disease in later life. METHODS:All women admitted to the Academic Medical Centre between January 1984 and Janua...

journal_title：Hypertension in pregnancy

authors： van Pampus MG,Wolf H,Mayruhu G,Treffers PE,Bleker OP

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...

journal_title：Hypertension in pregnancy

authors： Thakoordeen S,Moodley J,Naicker T

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE(S):We tested the hypothesis that twin pregnancies would lead to increased maternal plasma homocysteine. We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies without preeclampsia and normal singleton pregnancies. METHOD...

journal_title：Hypertension in pregnancy

authors： Powers RW,Dunbar MS,Laivuori HM,Harger GF,Lykins DL,Roberts JM

更新日期：2005-01-01 00:00:00

abstract：:We examined neurological and intellectual outcome of growth-restricted newborns of pregnancies complicated with preeclampsia and without preeclampsia. Seventy-five consecutive growth restricted newborns (<5th percentile) were prospectively followed up at 6 months' intervals. Newborns with major congenital malformation...

journal_title：Hypertension in pregnancy

authors： Many A,Fattal A,Leitner Y,Kupferminc MJ,Harel S,Jaffa A

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the higher rate of preeclampsia previously reported in Black women is attributable to a higher rate of chronic hypertension in that group. METHODS:Rates and severity of pregnancy-related hypertensive disease in Black and White women with and without chronic hypertension were reviewed fro...

journal_title：Hypertension in pregnancy

authors： Bryant AS,Seely EW,Cohen A,Lieberman E

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS:Microarray-based study was carried out with placental samples. RESULTS:Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however,...

journal_title：Hypertension in pregnancy

authors： Betoni JS,Derr K,Pahl MC,Rogers L,Muller CL,Packard RE,Carey DJ,Kuivaniemi H,Tromp G

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS:131 pregnant women cons...

journal_title：Hypertension in pregnancy

authors： Babar A,Bujold E,Leblanc V,Lavoie-Lebel É,Paquette J,Bazinet L,Lemieux S,Marc I,Abdous B,Dodin S

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS:A prospective case-control study included a study group consisting of 30 pregnant women with p...

journal_title：Hypertension in pregnancy

authors： Milosevic-Stevanovic J,Krstic M,Radovic-Janosevic D,Stefanovic M,Antic V,Djordjevic I

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:This study investigated endothelin-1 (ET-1) production induced by vascular endothelial growth factor (VEGF) in two different vascular wall cell types. METHODS:We analyzed the effect of endothelin-converting enzyme-1 (ECE-1) inhibitor and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) on VEGF-induce...

journal_title：Hypertension in pregnancy

authors： Seol HJ,Oh MJ,Kim HJ

更新日期：2011-01-01 00:00:00