A mass spectrometric multicenter study supports classification of preeclampsia as heterogeneous disorder.

Abstract:

OBJECTIVE:The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. METHODS:Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four centers were prospectively analyzed with predefined rule sets. RESULTS:Overall sample classification reached sensitivity of 0.88 and specificity of 0.73. Separate calculations for early-onset PEs only (before 34 weeks of gestation) revealed sensitivity of 0.88 and specificity of 0.89. CONCLUSION:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry serum-profiling with center-wise standardization offers a fast and robust method to classify PE and contributes to the theory of PE being a heterogeneous disorder that ought to be subclassified.

journal_name

Hypertens Pregnancy

authors

Pecks U,Schütt A,Röwer C,Reimer T,Schmidt M,Preschany S,Stepan H,Rath W,Glocker MO

doi

10.3109/10641955.2011.640375

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

278-91

issue

2

eissn

1064-1955

issn

1525-6065

journal_volume

31

pub_type

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