Connexin expression is not altered in omental resistance vessels from women with preeclampsia.

Abstract:

OBJECTIVE:To compare connexin expression in omental resistance arteries from preeclamptic women and normal gravidas. METHODS:Small arteries (approximately 200-400 microm i.d.) were dissected from omental fat biopsies, taken at cesarean delivery from normotensive and preeclamptic women. Vessels were frozen and homogenized, then connexin-43 protein was detected by Western blot and quantitated by comparison with alpha-actin. RESULTS:Connexin-43 was detected in all specimens, primarily in its phosphorylated form. Abundance did not differ between vessels from preeclamptic and normotensive gravidas. CONCLUSIONS:Phasic activity in omental resistance vessels from preeclamptic women likely depends on abnormal genesis of an oscillatory signal rather than on more extensive gap junctional communication between vascular cells.

journal_name

Hypertens Pregnancy

authors

Umans JG,Lindheimer MD,Hack B,Davidson-Garcia CA

doi

10.1081/PRG-100104178

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

119-24

issue

1

eissn

1064-1955

issn

1525-6065

pii

100104178

journal_volume

20

pub_type

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