Mechanisms of endothelium-dependent relaxation in myometrial resistance vessels and their alteration in preeclampsia.

abstract：:The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...

journal_title：Hypertension in pregnancy

authors： Namlı Kalem M,Kalem Z,Yüce T,Soylemez F

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. METHODS:Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four...

journal_title：Hypertension in pregnancy

authors： Pecks U,Schütt A,Röwer C,Reimer T,Schmidt M,Preschany S,Stepan H,Rath W,Glocker MO

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the levels of serum lipoproteins in women with pregnancy-induced hypertension and compare it with the corresponding levels in pregnant women having normal blood pressure. METHOD:This cross-sectional study was conducted in the three tertiary care hospitals of Peshawar, North West Frontier Provinc...

journal_title：Hypertension in pregnancy

authors： Jan MR,Nazli R,Shah J,Akhtar T

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Oxidative stress and a generalized inflammatory state are features of preeclampsia (PE). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with PE, and to determine the relationship between oxidative stress and inflammation in P...

journal_title：Hypertension in pregnancy

authors： Ouyang YQ,Li SJ,Zhang Q,Cai HB,Chen HP

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...

journal_title：Hypertension in pregnancy

authors： Livingston JC,Ahokas R,Haddad B,Sibai BM,Awaads R

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To determine if the phosphodiesterase type 5 inhibitor sildenafil prolongs pregnancy in women with preeclampsia. METHODS:Women with preeclampsia at gestational ages 24-34 weeks were recruited from nine hospitals in the UK, and randomly assigned to sildenafil citrate or placebo. Medication was increased every...

journal_title：Hypertension in pregnancy

authors： Samangaya RA,Mires G,Shennan A,Skillern L,Howe D,McLeod A,Baker PN

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:This study investigated endothelin-1 (ET-1) production induced by vascular endothelial growth factor (VEGF) in two different vascular wall cell types. METHODS:We analyzed the effect of endothelin-converting enzyme-1 (ECE-1) inhibitor and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) on VEGF-induce...

journal_title：Hypertension in pregnancy

authors： Seol HJ,Oh MJ,Kim HJ

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS:Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was ...

journal_title：Hypertension in pregnancy

authors： Keshavarzi F,Mehdizadeh S,Khazaie H,Ghadami MR

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Escherichia coli O157:H7 is a common cause of bacterial gastroenteritis and may increase the risk of hypertension. We studied the risk of hypertension in pregnancy following a large E. coli O157:H7 outbreak that occurred in Walkerton, Canada, in the year 2000. METHODS:We linked data collected from Walkerton...

journal_title：Hypertension in pregnancy

authors： Nevis IF,Sontrop JM,Clark WF,Huang A,McDonald S,Thabane L,Moist L,Macnab JJ,Suri R,Garg AX

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To report about a case of complicated late postpartum eclampsia where neonatal low birth weight could be considered a predictive factor of placental sufferance. METHODS:A 25-year-old woman, without medical or familiar history for hypertension or cerebrovascular diseases, underwent a normal spontaneous delive...

journal_title：Hypertension in pregnancy

authors： Tersigni C,Esposito G,Albanese A,D'Ippolito S,Sabatino G,Di Simone N,Caruso A

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...

journal_title：Hypertension in pregnancy

authors： Xuan J,Jing Z,Yuanfang Z,Xiaoju H,Pei L,Guiyin J,Yu Z

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Assess the actual rate of eclampsia in Sweden, describe the clinical picture of the disease and the maternal and perinatal outcomes. METHODS:Analysis of data regarding incidence of eclampsia registered in the Swedish Medical Birth Register 1991-1992. The records of all the cases with the diagnosis of eclamps...

journal_title：Hypertension in pregnancy

authors： Kullberg G,Lindeberg S,Hanson U

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To identify parameters that may assist clinicians in predicting which women will develop preeclampsia (PE) after initially presenting with gestational hypertension (GH). METHODS:118 women were recruited to the study with GH or PE. They were divided into three groups based on their diagnosis at delivery- (1) ...

journal_title：Hypertension in pregnancy

authors： Davis GK,Mackenzie C,Brown MA,Homer CS,Holt J,McHugh L,Mangos G

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate maternal and fetal outcome of the subsequent pregnancy of primiparous women with a history of early-onset intrauterine growth restriction (IUGR), prompting delivery before 34 weeks of gestation, without concomitant maternal hypertensive disease. DESIGN:Retrospective coho...

journal_title：Hypertension in pregnancy

authors： Evers AC,van Rijn BB,van Rossum MM,Bruinse HW

更新日期：2011-01-01 00:00:00

abstract：:Preeclampsia and intrauterine growth restriction are both characterized by placental malfunction. The pathological processes of abnormal trophoblast invasion, partial absence of maternal spiral artery modification, increased apoptosis of trophoblast cells, and placental ischemia are all associated with the release of ...

journal_title：Hypertension in pregnancy

authors： Tjoa ML,Oudejans CB,van Vugt JM,Blankenstein MA,van Wijk IJ

更新日期：2004-01-01 00:00:00

abstract：:Objectives: Establishment of association between: (a) Val158Met COMT (G1947A) polymorphism and preeclampsia; (b) cytokines gene expression and COMT genotypes. Methods: 50 preeclampsia and 50 healthy pregnant women were enrolled. COMT genotyping was done by PCR/RFLP. TNF-α, IL-1β, and IL-6 mRNA levels were determined b...

journal_title：Hypertension in pregnancy

authors： Sljivancanin Jakovljevic T,Kontic-Vucinic O,Nikolic N,Carkic J,Milasin J

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that the risk of preeclampsia in nulliparous women may be due to an anti-angiogenic state. METHODS:Maternal serum samples obtained in the third trimester from nulliparous (n = 86) and multiparous (n = 165) singleton uncomplicated pregnancies were analyzed for levels of angiogenic facto...

journal_title：Hypertension in pregnancy

authors： Bdolah Y,Elchalal U,Natanson-Yaron S,Yechiam H,Bdolah-Abram T,Greenfield C,Goldman-Wohl D,Milwidsky A,Rana S,Karumanchi SA,Yagel S,Hochner-Celnikier D

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known. METHODS:Subcutaneous fat biopsies were obtained at Cesarean section or abdominal surgery from 7 normal non-preg...

journal_title：Hypertension in pregnancy

authors： Cadden KA,Walsh SW

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS:131 pregnant women cons...

journal_title：Hypertension in pregnancy

authors： Babar A,Bujold E,Leblanc V,Lavoie-Lebel É,Paquette J,Bazinet L,Lemieux S,Marc I,Abdous B,Dodin S

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is synthesized in cardiac ventricles in response to volume expansion. This study evaluated NT-proBNP levels to determine the clinical correlation with the severity of hypertensive disorders complicating pregnancy. METHODS:NT-proBNP levels of 95 pregnan...

journal_title：Hypertension in pregnancy

authors： Seong WJ,Kim SC,Hong DG,Koo TB,Park IS

更新日期：2011-01-01 00:00:00

abstract：:We examined neurological and intellectual outcome of growth-restricted newborns of pregnancies complicated with preeclampsia and without preeclampsia. Seventy-five consecutive growth restricted newborns (<5th percentile) were prospectively followed up at 6 months' intervals. Newborns with major congenital malformation...

journal_title：Hypertension in pregnancy

authors： Many A,Fattal A,Leitner Y,Kupferminc MJ,Harel S,Jaffa A

更新日期：2003-01-01 00:00:00

abstract：:Intracranial hemorrhage and stroke are primary causes of maternal mortality in pregnancies affected by hypertensive disorders. As such antihypertensive therapy plays a crucial role in the management of severe hypertension. However, the target level to achieve the best outcome for both - mother and fetus - is still unc...

journal_title：Hypertension in pregnancy

authors： Wertaschnigg D,Wang R,Reddy M,Costa FDS,Mol BWJ,Rolnik DL

更新日期：2020-02-01 00:00:00

abstract：:Objective: Gestational hypertension (GH) is an important pregnancy complication. Sparse studies have shown a correlation between this complication and psychological disorders in patients. In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional stud...

journal_title：Hypertension in pregnancy

authors： Rezaei Ardani A,Tara F,Naghizadeh Kashani S,Hatami SB,Emadzadeh M,Nahidi M

更新日期：2020-05-01 00:00:00

abstract：:The pathophysiology of preeclampsia (PET) implicates an inflammatory dysfunction. This study profiled this host response by challenging whole blood with lipopolysaccharide. Multiplex immunoassays determined interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12(p70), IL-13, IL-17, granulocyte/granulo...

journal_title：Hypertension in pregnancy

authors： Brewster JA,Orsi NM,Gopichandran N,Ekbote UV,Cadogan E,Walker JJ

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Women with a history of preeclampsia have an increased risk of cardiovascular disease. Gynaecologists have an important role in the counselling and management of cardiovascular risk factors after preeclampsia. We aimed to assess the role of gynaecologists in informing women on interventions and risk factor fo...

journal_title：Hypertension in pregnancy

authors： van Kesteren F,Visser S,Hermes W,Teunissen PW,Franx A,van Pampus MG,Mol BW,de Groot CJ

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To compare fibrinogen concentration and factor VIII activity obtained from pregnant women with preeclampsia with those obtained from women with either normal pregnancies or with complications unrelated to preeclampsia. MATERIALS AND METHODS:Fibrinogen concentration and factor VIII activity were measured in t...

journal_title：Hypertension in pregnancy

authors： Williams VK,Griffiths AB,Carbone S,Hague WM

更新日期：2007-01-01 00:00:00

abstract：:Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female...

journal_title：Hypertension in pregnancy

authors： Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Low-dose aspirin can reduce the incidence of preeclampsia and intrauterine growth restriction (IUGR). However, the effects of ethnicity upon low-dose aspirin's efficacy has not been analyzed. Here, we comparatively evaluated the efficacy of low-dose aspirin in preventing preeclampsia and related fetal compli...

journal_title：Hypertension in pregnancy

authors： Gan J,He H,Qi H

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To examine the association between calcium levels during the first trimester of pregnancy and preeclampsia. METHODS:The study population included registered births (n = 5233) in a tertiary medical center between 2001 and 2011. A comparison was performed between women with and without hypocalcemia during the ...

journal_title：Hypertension in pregnancy

authors： Gabbay A,Tzur T,Weintraub AY,Shoham-Vardi I,Sergienko R,Sheiner E

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:There is evidence of altered vascular endothelial function in women with preeclampsia as well as in the endothelial cells from umbilical vessels of preeclamptic pregnancies. Matrix metalloproteinase (MMP)-2 is elevated in the plasma of preeclamptic women and is a mediator of vascular reactivity; however, whe...

journal_title：Hypertension in pregnancy

authors： Merchant SJ,Narumiya H,Zhang Y,Guilbert LJ,Davidge ST

更新日期：2004-01-01 00:00:00