MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.

Abstract:

OBJECTIVE:The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS:Microarray-based study was carried out with placental samples. RESULTS:Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets. CONCLUSION:The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.

journal_name

Hypertens Pregnancy

authors

Betoni JS,Derr K,Pahl MC,Rogers L,Muller CL,Packard RE,Carey DJ,Kuivaniemi H,Tromp G

doi

10.3109/10641955.2013.807819

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

321-39

issue

4

eissn

1064-1955

issn

1525-6065

journal_volume

32

pub_type

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