Presymptomatic prediction of preeclampsia with angiogenic factors, in high risk pregnant women.

Abstract:

INTRODUCTION:The aim of this study was to investigate the value of placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PLGF ratio, in predicting symptomatic preeclampsia (PE). METHODS:A prospective longitudinal study was carried out on 71 high risk preeclamptic women cohort. All of them had normal blood pressure level (≤140/90 mmHg) at the time of enrolment, 26.8 ± 1.5 weeks. Maternal blood was collected and plasma was stored in a freezer at -80 °C. PE was defined according to the National High Blood Pressure Education Program Working Group Criteria. Accuracy of angiogenic factors in predicting PE was evaluated using Receiver-operating characteristics. RESULTS:Maternal plasma concentrations of PLGF and sFlt-1 were able to predict PE (0.90, p < 001; 0.78, p = 0.003, area under the curve, respectively) but the sFlt-1/PLGF ratio presented the best prediction potential over the others (0.95, area under the curve, p < 0.001). CONCLUSION:All angiogenesis factors were effective biomarkers in predicting PE during the second trimester, before the clinical onset of PE.

journal_name

Hypertens Pregnancy

authors

Teixeira PG,Reis ZS,Andrade SP,Rezende CA,Lage EM,Velloso EP,Santana CA,Cabral AC

doi

10.3109/10641955.2013.807818

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

312-20

issue

3

eissn

1064-1955

issn

1525-6065

journal_volume

32

pub_type

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