Abstract:
OBJECTIVE:We examined serum concentrations of basic fibroblast growth factor (bFGF) in women with hypertensive disorders in pregnancy and analyzed whether serum concentrations of bFGF can be used as a discriminator between mild and severe preeclampsia. METHODS:One hundred and twenty pregnant women were included in this prospective cohort study. We evaluated serum concentrations of bFGF in pregnant women with chronic hypertension (n=22), mild preeclampsia (n=40), severe preeclampsia (n=31), and healthy pregnant women (n=27). RESULTS:Median serum concentrations of bFGF in healthy pregnant women, women with chronic hypertension, and women with mild or severe preeclampsia were 0.0 (0-37.2), 0.0 (0-3.0), 1.7 (0-97.2), and 0.0 (0-52.0), respectively. Comparison of the median values of serum bFGF concentrations showed a significant difference between healthy pregnant women and women with mild preeclampsia (P=0.02). In a logistic regression model, we found a significant influence of bFGF serum concentrations on the diagnosis of mild preeclampsia (P=0.01), but not on the diagnosis of chronic hypertension (P=0.19) or severe preeclampsia (P=0.41). CONCLUSIONS:Elevated serum concentrations of bFGF are associated with mild preeclampsia, but are not discriminatory for the distinction between mild and severe preeclampsia.
journal_name
Hypertens Pregnancyjournal_title
Hypertension in pregnancyauthors
Hohlagschwandtner M,Knöfler M,Ploner M,Zeisler H,Joura EA,Husslein Pdoi
10.1081/PRG-120016790keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
235-41issue
3eissn
1064-1955issn
1525-6065pii
120016790journal_volume
21pub_type
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journal_title:Hypertension in pregnancy
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-45774
更新日期:2005-01-01 00:00:00
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journal_title:Hypertension in pregnancy
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journal_title:Hypertension in pregnancy
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
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journal_title:Hypertension in pregnancy
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doi:10.1081/PRG-200030860
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...
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更新日期:2017-02-01 00:00:00
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journal_title:Hypertension in pregnancy
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1397690
更新日期:2018-02-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120016791
更新日期:2003-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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journal_title:Hypertension in pregnancy
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950600912976
更新日期:2006-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1197936
更新日期:2016-11-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1749279
更新日期:2020-05-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2018.1498879
更新日期:2018-08-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120002906
更新日期:2002-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1100311
更新日期:2016-01-01 00:00:00
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doi:10.3109/10641955.2010.544804
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