Objective assessment of obstructive sleep apnea in normal pregnant and preeclamptic women.

Abstract:

OBJECTIVE:Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS:Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP) > 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (+ 1 in dipsticks) in random samples. Objective sleep apnea was evaluated using an overnight in-hospital sleep evaluation using the SOMNOwatch plus Respiratory Screener. OSA was defined as an apnea-hypopnea index (AHI) ≥ 5, and further grouped into severity categories: mild (5-14.9), moderate (15-29.9), and severe (≥ 30). RESULTS:Mean AHI was 33.3 ± 12.1 in preeclamptic women and was 23.8 ± 15.8 in normal pregnant women (p = 0.008). There was significant difference in prevalence of OSA severity (none, mild, moderate, or severe) between groups. Out of 33 preeclamptic women, 11 women had moderate and 22 women had severe OSA. Whereas, among 33 normal pregnant women, 8, 13, and10 women had mild, moderate, and severe OSA, respectively. Two normal pregnant women had no OSA (AHI< 5). CONCLUSION:Our study suggests women are susceptible to developing OSA during pregnancy that is associated with an increased risk of preeclampsia.

journal_name

Hypertens Pregnancy

authors

Keshavarzi F,Mehdizadeh S,Khazaie H,Ghadami MR

doi

10.1080/10641955.2018.1498879

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

154-159

issue

3

eissn

1064-1955

issn

1525-6065

journal_volume

37

pub_type

杂志文章
  • Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats.

    abstract::Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2019.1647232

    authors: Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

    更新日期:2019-11-01 00:00:00

  • Fibrinolysis parameters in Sudanese women with severe preeclampsia.

    abstract:BACKGROUND:Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES:A case-control study was conducted in Medani Hospital, Sudan...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1211676

    authors: Elzein HO,Muddathir AR,Rida M,Rayis DA,Elhassan EM,Adam I

    更新日期:2016-11-01 00:00:00

  • Heat shock protein 70 is not increased in women with severe preeclampsia.

    abstract:OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120004767

    authors: Livingston JC,Ahokas R,Haddad B,Sibai BM,Awaads R

    更新日期:2002-01-01 00:00:00

  • Changes in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial.

    abstract:OBJECTIVES:The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS:131 pregnant women cons...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/10641955.2018.1446977

    authors: Babar A,Bujold E,Leblanc V,Lavoie-Lebel É,Paquette J,Bazinet L,Lemieux S,Marc I,Abdous B,Dodin S

    更新日期:2018-05-01 00:00:00

  • Preeclampsia with and without intrauterine growth restriction-Two pathogenetically different entities?

    abstract:OBJECTIVE:The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS:A prospective case-control study included a study group consisting of 30 pregnant women with p...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1212872

    authors: Milosevic-Stevanovic J,Krstic M,Radovic-Janosevic D,Stefanovic M,Antic V,Djordjevic I

    更新日期:2016-11-01 00:00:00

  • Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia.

    abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-200030860

    authors: Teran E,Escudero C,Vivero S,Enriquez A,Calle A

    更新日期:2004-01-01 00:00:00

  • A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the north west frontier province-Pakistan.

    abstract:OBJECTIVES:To evaluate the levels of serum lipoproteins in women with pregnancy-induced hypertension and compare it with the corresponding levels in pregnant women having normal blood pressure. METHOD:This cross-sectional study was conducted in the three tertiary care hospitals of Peshawar, North West Frontier Provinc...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.507843

    authors: Jan MR,Nazli R,Shah J,Akhtar T

    更新日期:2012-01-01 00:00:00

  • Feto-maternal correlation of PTX3, sFlt-1 and PlGF in physiological and pre-eclamptic pregnancies.

    abstract:OBJECTIVE:PTX3, sFlt-1 and PlGF levels in maternal blood are altered in some obstetric diseases, such as preeclampsia (PE). Nonetheless, only few data on their expression in the fetal compartment have been reported so far. STUDY DESIGN:An observational study was performed by prospectively collecting maternal and fetal...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2014.903962

    authors: Algeri P,Ornaghi S,Bernasconi DP,Cappellini F,Signorini S,Brambilla P,Urban G,Vergani P

    更新日期:2014-08-01 00:00:00

  • MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.

    abstract:OBJECTIVE:The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS:Microarray-based study was carried out with placental samples. RESULTS:Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however,...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,评审

    doi:10.3109/10641955.2013.807819

    authors: Betoni JS,Derr K,Pahl MC,Rogers L,Muller CL,Packard RE,Carey DJ,Kuivaniemi H,Tromp G

    更新日期:2013-11-01 00:00:00

  • Fetal DNA quantitation in peripheral blood is not useful as a marker of disease severity in women with preeclampsia.

    abstract:OBJECTIVE:Trophoblast migration into the maternal circulation is increased in preeclampsia and can trigger the endothelial dysfunction that characterizes the clinical disease. We hypothesised that 'fetal trafficking' is increased in women with severe preeclampsia and that the quantity of trafficking is greater in women...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120021062

    authors: Byrne BM,Crowley A,Taulo F,Anthony J,O'Leary JJ,O'Herlihy C

    更新日期:2003-01-01 00:00:00

  • Elevated serum-soluble Fas in preeclampsia: correlation with clinical, laboratory, and Doppler parameters.

    abstract:OBJECTIVES:(i) To compare the levels of soluble Fas (sFas) in the sera of patients with variable degrees of preeclampsia and in healthy gravidas; and (ii) to correlate sFas with clinical, laboratory, and Doppler parameters in preeclampsia. METHODS:Fifty patients with mild preeclampsia, 50 patients with severe preeclam...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.544804

    authors: El-Sherbiny W,Soliman A,El-Mazny A

    更新日期:2011-01-01 00:00:00

  • Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies.

    abstract:OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1242605

    authors: Maymon R,Trahtenherts A,Svirsky R,Melcer Y,Madar-Shapiro L,Klog E,Meiri H,Cuckle H

    更新日期:2017-02-01 00:00:00

  • Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk?

    abstract:BACKGROUND:Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we de...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1258411

    authors: Lin LT,Hu LY,Tang PL,Tsui KH,Cheng JT,Huang WC,Chang HT

    更新日期:2017-05-01 00:00:00

  • Incidence of superimposed preeclampsia among pregnant Asian women with chronic hypertension.

    abstract:OBJECTIVE:To determine the incidence and associated factors of superimposed preeclampsia among pregnant women with chronic hypertension. METHODS:A total of 300 pregnant women diagnosed with chronic hypertension were reviewed. Data were retrieved from medical records, including obstetric data, characteristics of hypert...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1311340

    authors: Boriboonhirunsarn D,Pradyachaipimol A,Viriyapak B

    更新日期:2017-05-01 00:00:00

  • Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low.

    abstract:OBJECTIVE:To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine. METHODS:Blood pressure and FHT categories were assessed one hour before and after medication administration. Hy...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2015.1117098

    authors: Sharma KJ,Rodriguez M,Kilpatrick SJ,Greene N,Aghajanian P

    更新日期:2016-01-01 00:00:00

  • Management of severe pregnancy-induced hypertension after 34 weeks of gestation: A prospective study to reduce the rate of cesarean section.

    abstract:OBJECTIVE:The aim of this study was to reduce the rate of cesarean section (CS) in severe pregnancy-induced hypertension (PIH) by introducing a set of indicative criteria for CS. METHODS:Labor induction was attempted in Japanese patients (n = 41) with severe PIH after 34 weeks of gestation. Vital signs and symptoms th...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2015.1115061

    authors: Shibata T,Nakago S,Kato H,Tokuda H,Matsuki R,Kotsuji F

    更新日期:2016-01-01 00:00:00

  • The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2.

    abstract:BACKGROUND:There is evidence of altered vascular endothelial function in women with preeclampsia as well as in the endothelial cells from umbilical vessels of preeclamptic pregnancies. Matrix metalloproteinase (MMP)-2 is elevated in the plasma of preeclamptic women and is a mediator of vascular reactivity; however, whe...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120028281

    authors: Merchant SJ,Narumiya H,Zhang Y,Guilbert LJ,Davidge ST

    更新日期:2004-01-01 00:00:00

  • Cytokine production by monocytes, NK cells, and lymphocytes is different in preeclamptic patients as compared with normal pregnant women.

    abstract:OBJECTIVE:To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS:Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lympho...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701885006

    authors: van Nieuwenhoven AL,Moes H,Heineman MJ,Santema J,Faas MM

    更新日期:2008-01-01 00:00:00

  • ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.

    abstract::The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1397690

    authors: Namlı Kalem M,Kalem Z,Yüce T,Soylemez F

    更新日期:2018-02-01 00:00:00

  • Low neonatal birth weight as a possible predictive factor for the onset of postpartum eclampsia.

    abstract:OBJECTIVE:To report about a case of complicated late postpartum eclampsia where neonatal low birth weight could be considered a predictive factor of placental sufferance. METHODS:A 25-year-old woman, without medical or familiar history for hypertension or cerebrovascular diseases, underwent a normal spontaneous delive...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.506231

    authors: Tersigni C,Esposito G,Albanese A,D'Ippolito S,Sabatino G,Di Simone N,Caruso A

    更新日期:2011-01-01 00:00:00

  • A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia.

    abstract:OBJECTIVE:To determine if the phosphodiesterase type 5 inhibitor sildenafil prolongs pregnancy in women with preeclampsia. METHODS:Women with preeclampsia at gestational ages 24-34 weeks were recruited from nine hospitals in the UK, and randomly assigned to sildenafil citrate or placebo. Medication was increased every...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/10641950802601278

    authors: Samangaya RA,Mires G,Shennan A,Skillern L,Howe D,McLeod A,Baker PN

    更新日期:2009-08-01 00:00:00

  • Patterns of pregnancy-related hypertension in black and white women.

    abstract:OBJECTIVE:To determine whether the higher rate of preeclampsia previously reported in Black women is attributable to a higher rate of chronic hypertension in that group. METHODS:Rates and severity of pregnancy-related hypertensive disease in Black and White women with and without chronic hypertension were reviewed fro...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950500281134

    authors: Bryant AS,Seely EW,Cohen A,Lieberman E

    更新日期:2005-01-01 00:00:00

  • Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia.

    abstract:OBJECTIVE:Pre-eclampsia is associated with significant maternal and neonatal complications, and delivery is often expedited to minimise complications. For randomised trials evaluating interventions in women with late-onset (>34 weeks) mild to moderate pre-eclampsia, no single outcome has been identified to be the most ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2013.837176

    authors: Fong F,Rogozinska E,Allotey J,Kempley S,Shah DK,Thangaratinam S

    更新日期:2014-05-01 00:00:00

  • Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity.

    abstract:OBJECTIVE:To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). METHODS:A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and materna...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2014.913615

    authors: Christiansen M,Hedley PL,Placing S,Wøjdemann KR,Carlsen AL,Jørgensen JM,Gjerris AC,Shalmi AC,Rode L,Sundberg K,Tabor A

    更新日期:2015-11-01 00:00:00

  • The activity of erythrocyte sodium-proton exchanger in women with pregnancy- induced hypertension.

    abstract:BACKGROUND:Hypertension that develops after 20 gestational weeks and is defined as pregnancy-induced hypertension (PIH). The main cause of PIH is vasoconstriction and the thickening of vascular media, which decreases vascular capacity and increases peripheral resistance. One of the theories postulated to explain this p...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950600601835

    authors: Kwiatkowski S,Kwiatkowska E,Czajka R,Ciechanowski K,Kedzierska K,Bober J,Rzepka R,Golembiewska E,Chlubek D

    更新日期:2006-01-01 00:00:00

  • Markers for presymptomatic prediction of preeclampsia and intrauterine growth restriction.

    abstract::Preeclampsia and intrauterine growth restriction are both characterized by placental malfunction. The pathological processes of abnormal trophoblast invasion, partial absence of maternal spiral artery modification, increased apoptosis of trophoblast cells, and placental ischemia are all associated with the release of ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,评审

    doi:10.1081/PRG-120028292

    authors: Tjoa ML,Oudejans CB,van Vugt JM,Blankenstein MA,van Wijk IJ

    更新日期:2004-01-01 00:00:00

  • Serum apelin and galectin-3 in preeclampsia in Iraq.

    abstract:OBJECTIVE:This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS:Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS:The PE group had significantly lower apelin...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1777300

    authors: Sattar Taha A,Zahraei Z,Al-Hakeim HK

    更新日期:2020-11-01 00:00:00

  • Subsequent pregnancy outcome after first pregnancy with normotensive early-onset intrauterine growth restriction at

    abstract:OBJECTIVE:The aim of this study was to evaluate maternal and fetal outcome of the subsequent pregnancy of primiparous women with a history of early-onset intrauterine growth restriction (IUGR), prompting delivery before 34 weeks of gestation, without concomitant maternal hypertensive disease. DESIGN:Retrospective coho...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.484080

    authors: Evers AC,van Rijn BB,van Rossum MM,Bruinse HW

    更新日期:2011-01-01 00:00:00

  • Hemodynamic adaptation during pregnancy in chronic hypertension.

    abstract:OBJECTIVE:To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy. METHODS:Stroke volume index (SI), heart rate (HR), cardiac output index (CI), systemic vascular resistance index (SVRI), pulse wave velocity (PWV), and left cardiac work index (LCWI) were measured using whole-bod...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701436016

    authors: Tihtonen K,Kööbi T,Huhtala H,Uotila J

    更新日期:2007-01-01 00:00:00

  • Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia.

    abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1280049

    authors: Thakoordeen S,Moodley J,Naicker T

    更新日期:2017-05-01 00:00:00