Cytokine production by monocytes, NK cells, and lymphocytes is different in preeclamptic patients as compared with normal pregnant women.

Abstract:

OBJECTIVE:To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS:Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lymphocytes and NK cells and the percentages of TNFalpha, IL-1 beta, and IL-12 producing monocytes were measured by flowcytometry. RESULTS:In women with preeclampsia, there was a significantly increased percentage IL-4 producing cytotoxic T cells. Also, a significant decreased percentage IL-2 producing T helper cells and IL-12 producing monocytes was seen as compared with normal pregnancy. CONCLUSION:Th1 cytokine production of lymphocytes and monocytes appears to be decreased in our group of preeclamptic patients compared with normal pregnant women.

journal_name

Hypertens Pregnancy

authors

van Nieuwenhoven AL,Moes H,Heineman MJ,Santema J,Faas MM

doi

10.1080/10641950701885006

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

207-24

issue

3

eissn

1064-1955

issn

1525-6065

pii

901517352

journal_volume

27

pub_type

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