Abstract:
OBJECTIVE:To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy. METHODS:Stroke volume index (SI), heart rate (HR), cardiac output index (CI), systemic vascular resistance index (SVRI), pulse wave velocity (PWV), and left cardiac work index (LCWI) were measured using whole-body impedance cardiography. Systolic blood pressure (SAP), mean arterial pressure (MAP), diastolic blood pressure (DAP), and pulse pressure (PP) were also measured. Arterial compliance was defined as the SI-to-PP ratio (SI/PP). Hemodynamic parameters and NT-proANP concentrations were assessed during the early and late second trimester, the third trimester, and after delivery in 20 women with essential hypertension and 30 normotensive women. RESULTS:Arterial blood pressure, SVRI, and PWV remained higher during the whole study period in chronic hypertensive compared with healthy pregnancies. In the early second trimester, women with chronic hypertension had significantly lower SI and NT-proANP concentrations than did normotensive women. CONCLUSION:The hemodynamics of chronic hypertension during pregnancy are characterized by persistent high vascular resistance. Lower SI and NT-proANP values found in chronic hypertensive pregnancies during the early second trimester may suggest a reduced intravascular volume increase during pregnancy.
journal_name
Hypertens Pregnancyjournal_title
Hypertension in pregnancyauthors
Tihtonen K,Kööbi T,Huhtala H,Uotila Jdoi
10.1080/10641950701436016subject
Has Abstractpub_date
2007-01-01 00:00:00pages
315-28issue
3eissn
1064-1955issn
1525-6065pii
781393990journal_volume
26pub_type
杂志文章abstract:OBJECTIVE:Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS:Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2018.1498879
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1280049
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:We examined serum concentrations of basic fibroblast growth factor (bFGF) in women with hypertensive disorders in pregnancy and analyzed whether serum concentrations of bFGF can be used as a discriminator between mild and severe preeclampsia. METHODS:One hundred and twenty pregnant women were included in thi...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120016790
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Pre-eclampsia is associated with significant maternal and neonatal complications, and delivery is often expedited to minimise complications. For randomised trials evaluating interventions in women with late-onset (>34 weeks) mild to moderate pre-eclampsia, no single outcome has been identified to be the most ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2013.837176
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Caesarean section (CS) is one of the most frequently performed surgical procedures worldwide. Surgical variants include closure and non-closure of the peritoneum: in case of non-suturing the visceral peritoneum (VP), abnormal fluid collections such as blood clots may lead to formation of a hematoperitoneum...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802601229
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES:A case-control study was conducted in Medani Hospital, Sudan...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1211676
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:There is evidence of altered vascular endothelial function in women with preeclampsia as well as in the endothelial cells from umbilical vessels of preeclamptic pregnancies. Matrix metalloproteinase (MMP)-2 is elevated in the plasma of preeclamptic women and is a mediator of vascular reactivity; however, whe...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120028281
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to quantify adiponectin levels in women with normal and hypertensive pregnancies to determine whether there is an independent association, while controlling for body fat and insulin sensitivity. METHODS:A cross-sectional study was conducted in the following categories: 12 normotensi...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950600912976
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity. METHODS:Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography. RESULTS:Sodium nitroprusside-i...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10601330701274824
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To compare fibrinogen concentration and factor VIII activity obtained from pregnant women with preeclampsia with those obtained from women with either normal pregnancies or with complications unrelated to preeclampsia. MATERIALS AND METHODS:Fibrinogen concentration and factor VIII activity were measured in t...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701548240
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:This study investigated endothelin-1 (ET-1) production induced by vascular endothelial growth factor (VEGF) in two different vascular wall cell types. METHODS:We analyzed the effect of endothelin-converting enzyme-1 (ECE-1) inhibitor and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) on VEGF-induce...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641950903115053
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known. METHODS:Subcutaneous fat biopsies were obtained at Cesarean section or abdominal surgery from 7 normal non-preg...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950801958067
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). METHODS:This cross-sectional study was c...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2018.1524477
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and associated factors of superimposed preeclampsia among pregnant women with chronic hypertension. METHODS:A total of 300 pregnant women diagnosed with chronic hypertension were reviewed. Data were retrieved from medical records, including obstetric data, characteristics of hypert...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1311340
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS:Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lympho...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701885006
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that the risk of preeclampsia in nulliparous women may be due to an anti-angiogenic state. METHODS:Maternal serum samples obtained in the third trimester from nulliparous (n = 86) and multiparous (n = 165) singleton uncomplicated pregnancies were analyzed for levels of angiogenic facto...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2013.858745
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. METHODS:Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,多中心研究
doi:10.3109/10641955.2011.640375
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1117099
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To determine whether Chlamydia pneumoniae antibodies and highly sensitive C-reactive protein (hsCRP) levels in maternal sera are associated with preeclampsia or gestational hypertension. METHODS:C. pneumoniae antibodies and hsCRP levels were measured in maternal serum during first trimester (mean, 10.4 weeks...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701885188
更新日期:2008-01-01 00:00:00
abstract::Objective: Gestational hypertension (GH) is an important pregnancy complication. Sparse studies have shown a correlation between this complication and psychological disorders in patients. In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional stud...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1749279
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:Assess the actual rate of eclampsia in Sweden, describe the clinical picture of the disease and the maternal and perinatal outcomes. METHODS:Analysis of data regarding incidence of eclampsia registered in the Swedish Medical Birth Register 1991-1992. The records of all the cases with the diagnosis of eclamps...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120002906
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we de...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1258411
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Case report of a 35-year-old gravida 3, para 2, at 40 + 6 weeks with massive respiratory dysfunction with need of oxygenation, requiring cesarean section. CASE REPORT:Postpartum investigations revealed pathological cardiomegaly with left ventricular failure (NYHAIV). Cardiac biopsy diagnosed postpartum dilat...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2012.679014
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-200030860
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To report a case of cardiac arrhythmia related to a low dose of endovenous lanatoside C. CASE REPORT:A 23-year-old pregnant woman with mitral regurgitation complicated with preeclampsia and pulmonary edema presented 2 episodes of atrial tachycardia induced by a intravenous digitalis (2 mg, IV and 1 mg, IV, r...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641950902928571
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Oxidative stress and a generalized inflammatory state are features of preeclampsia (PE). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with PE, and to determine the relationship between oxidative stress and inflammation in P...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802233064
更新日期:2009-02-01 00:00:00
abstract::The pathophysiology of preeclampsia (PET) implicates an inflammatory dysfunction. This study profiled this host response by challenging whole blood with lipopolysaccharide. Multiplex immunoassays determined interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12(p70), IL-13, IL-17, granulocyte/granulo...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701826067
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE(S):We tested the hypothesis that twin pregnancies would lead to increased maternal plasma homocysteine. We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies without preeclampsia and normal singleton pregnancies. METHOD...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-45774
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To examine the management of early-onset preeclampsia and its maternal and fetal morbidity and mortality. DESIGN:Retrospective cohort study of 49,812 births at a university teaching hospital between June 1986 and March 1997. Seventy-one women were identified with a diagnosis of preeclampsia with an onset at ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/prg-100100138
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). METHODS:A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and materna...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2014.913615
更新日期:2015-11-01 00:00:00