A study of lipoproteins in normal and pregnancy induced hypertensive women in tertiary care hospitals of the north west frontier province-Pakistan.

Abstract:

OBJECTIVES:To evaluate the levels of serum lipoproteins in women with pregnancy-induced hypertension and compare it with the corresponding levels in pregnant women having normal blood pressure. METHOD:This cross-sectional study was conducted in the three tertiary care hospitals of Peshawar, North West Frontier Province, Pakistan. A total of 206 pregnant women at gestational age of >20 weeks were registered in the study after taking informed consent. All relevant information was recorded on a predesigned questionnaire. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and triglyceride (TG) levels were measured in 151 women with pregnancy induced hypertension (PIH) and compared with the corresponding values for a control group of 55 normotensive pregnant women. RESULT:Cholesterol levels were not statistically different between the patient group and controls. Triglyceride levels were significantly higher in the patient group than in controls. Women who developed hypertension after 20 weeks of gestation had 6.7, 4.2, 40.5, and 39.7% higher concentrations of TC, LDL-C, VLDL-C, and TG, respectively, and 28, 22.4, and 67.6% higher ratios of TC : HDL-C, LDL-C : HDL-C, and TG : HDL-C, respectively, as compared to the control subjects. The mean difference of the concentrations of HDL-C, VLDL-C, and TG, and the ratios TC : HDL-C, LDL-C : HDL-C, TG : HDL-C, and HDL-C : VLDL-C between the patients and control group was statistically significant. CONCLUSION:The assessment of blood lipids may be helpful in the prevention of complications in PIH patients.

journal_name

Hypertens Pregnancy

authors

Jan MR,Nazli R,Shah J,Akhtar T

doi

10.3109/10641955.2010.507843

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

292-9

issue

2

eissn

1064-1955

issn

1525-6065

journal_volume

31

pub_type

杂志文章
  • The effects of preeclampsia and oxygen environment on endothelial release of matrix metalloproteinase-2.

    abstract:BACKGROUND:There is evidence of altered vascular endothelial function in women with preeclampsia as well as in the endothelial cells from umbilical vessels of preeclamptic pregnancies. Matrix metalloproteinase (MMP)-2 is elevated in the plasma of preeclamptic women and is a mediator of vascular reactivity; however, whe...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120028281

    authors: Merchant SJ,Narumiya H,Zhang Y,Guilbert LJ,Davidge ST

    更新日期:2004-01-01 00:00:00

  • Markers for presymptomatic prediction of preeclampsia and intrauterine growth restriction.

    abstract::Preeclampsia and intrauterine growth restriction are both characterized by placental malfunction. The pathological processes of abnormal trophoblast invasion, partial absence of maternal spiral artery modification, increased apoptosis of trophoblast cells, and placental ischemia are all associated with the release of ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,评审

    doi:10.1081/PRG-120028292

    authors: Tjoa ML,Oudejans CB,van Vugt JM,Blankenstein MA,van Wijk IJ

    更新日期:2004-01-01 00:00:00

  • VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia.

    abstract::Objectives: Establishment of association between: (a) Val158Met COMT (G1947A) polymorphism and preeclampsia; (b) cytokines gene expression and COMT genotypes. Methods: 50 preeclampsia and 50 healthy pregnant women were enrolled. COMT genotyping was done by PCR/RFLP. TNF-α, IL-1β, and IL-6 mRNA levels were determined b...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1843663

    authors: Sljivancanin Jakovljevic T,Kontic-Vucinic O,Nikolic N,Carkic J,Milasin J

    更新日期:2020-11-01 00:00:00

  • Fibrinolysis parameters in Sudanese women with severe preeclampsia.

    abstract:BACKGROUND:Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES:A case-control study was conducted in Medani Hospital, Sudan...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1211676

    authors: Elzein HO,Muddathir AR,Rida M,Rayis DA,Elhassan EM,Adam I

    更新日期:2016-11-01 00:00:00

  • Protein/creatinine ratio on random urine samples for prediction of proteinuria in preeclampsia.

    abstract:OBJECTIVE:To evaluate Protein/Creatinine ratio on random urine samples for prediction of proteinuria in preeclampsia. MATERIALS AND METHODS:This study was performed on 150 pregnant women who were hospitalized as preeclampsia in Ghaem Hospital during 2006. At first, a 24-hours urine sample was collected for each patien...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.507838

    authors: Roudsari FV,Ayati S,Ayatollahi H,Shakeri MT

    更新日期:2012-01-01 00:00:00

  • Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity.

    abstract:OBJECTIVE:To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). METHODS:A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and materna...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2014.913615

    authors: Christiansen M,Hedley PL,Placing S,Wøjdemann KR,Carlsen AL,Jørgensen JM,Gjerris AC,Shalmi AC,Rode L,Sundberg K,Tabor A

    更新日期:2015-11-01 00:00:00

  • Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats.

    abstract::Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2019.1647232

    authors: Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

    更新日期:2019-11-01 00:00:00

  • The activity of erythrocyte sodium-proton exchanger in women with pregnancy- induced hypertension.

    abstract:BACKGROUND:Hypertension that develops after 20 gestational weeks and is defined as pregnancy-induced hypertension (PIH). The main cause of PIH is vasoconstriction and the thickening of vascular media, which decreases vascular capacity and increases peripheral resistance. One of the theories postulated to explain this p...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950600601835

    authors: Kwiatkowski S,Kwiatkowska E,Czajka R,Ciechanowski K,Kedzierska K,Bober J,Rzepka R,Golembiewska E,Chlubek D

    更新日期:2006-01-01 00:00:00

  • Antepartum middle mean cerebral blood flow velocity correlation with maternal hemodynamics.

    abstract:OBJECTIVE:To determine the correlation between simultaneous assessment of maternal middle cerebral blood flow velocity with the other maternal hemodynamic factors of cardiac output and mean arterial pressure. STUDY DESIGN:Eight normotensive patients were assessed. Maternal cerebral blood flow velocity was assessed usi...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641959909016200

    authors: Williams KP,Wilson S

    更新日期:1999-01-01 00:00:00

  • Patterns of pregnancy-related hypertension in black and white women.

    abstract:OBJECTIVE:To determine whether the higher rate of preeclampsia previously reported in Black women is attributable to a higher rate of chronic hypertension in that group. METHODS:Rates and severity of pregnancy-related hypertensive disease in Black and White women with and without chronic hypertension were reviewed fro...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950500281134

    authors: Bryant AS,Seely EW,Cohen A,Lieberman E

    更新日期:2005-01-01 00:00:00

  • Relationship between nulliparity and preeclampsia may be explained by altered circulating soluble fms-like tyrosine kinase 1.

    abstract:OBJECTIVE:To test the hypothesis that the risk of preeclampsia in nulliparous women may be due to an anti-angiogenic state. METHODS:Maternal serum samples obtained in the third trimester from nulliparous (n = 86) and multiparous (n = 165) singleton uncomplicated pregnancies were analyzed for levels of angiogenic facto...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2013.858745

    authors: Bdolah Y,Elchalal U,Natanson-Yaron S,Yechiam H,Bdolah-Abram T,Greenfield C,Goldman-Wohl D,Milwidsky A,Rana S,Karumanchi SA,Yagel S,Hochner-Celnikier D

    更新日期:2014-05-01 00:00:00

  • Incidence of superimposed preeclampsia among pregnant Asian women with chronic hypertension.

    abstract:OBJECTIVE:To determine the incidence and associated factors of superimposed preeclampsia among pregnant women with chronic hypertension. METHODS:A total of 300 pregnant women diagnosed with chronic hypertension were reviewed. Data were retrieved from medical records, including obstetric data, characteristics of hypert...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1311340

    authors: Boriboonhirunsarn D,Pradyachaipimol A,Viriyapak B

    更新日期:2017-05-01 00:00:00

  • A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia.

    abstract:OBJECTIVE:To determine if the phosphodiesterase type 5 inhibitor sildenafil prolongs pregnancy in women with preeclampsia. METHODS:Women with preeclampsia at gestational ages 24-34 weeks were recruited from nine hospitals in the UK, and randomly assigned to sildenafil citrate or placebo. Medication was increased every...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/10641950802601278

    authors: Samangaya RA,Mires G,Shennan A,Skillern L,Howe D,McLeod A,Baker PN

    更新日期:2009-08-01 00:00:00

  • Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia.

    abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1280049

    authors: Thakoordeen S,Moodley J,Naicker T

    更新日期:2017-05-01 00:00:00

  • Closure versus non-closure of the visceral peritoneum (VP) in patients with gestational hypertension--an observational analysis.

    abstract:INTRODUCTION:Caesarean section (CS) is one of the most frequently performed surgical procedures worldwide. Surgical variants include closure and non-closure of the peritoneum: in case of non-suturing the visceral peritoneum (VP), abnormal fluid collections such as blood clots may lead to formation of a hematoperitoneum...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950802601229

    authors: Malvasi A,Tinelli A,Hudelist G,Vergara D,Martignago R,Tinelli R

    更新日期:2009-01-01 00:00:00

  • Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia.

    abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-200030860

    authors: Teran E,Escudero C,Vivero S,Enriquez A,Calle A

    更新日期:2004-01-01 00:00:00

  • Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk?

    abstract:BACKGROUND:Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we de...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1258411

    authors: Lin LT,Hu LY,Tang PL,Tsui KH,Cheng JT,Huang WC,Chang HT

    更新日期:2017-05-01 00:00:00

  • Serum apelin and galectin-3 in preeclampsia in Iraq.

    abstract:OBJECTIVE:This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS:Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS:The PE group had significantly lower apelin...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1777300

    authors: Sattar Taha A,Zahraei Z,Al-Hakeim HK

    更新日期:2020-11-01 00:00:00

  • Hemodynamic adaptation during pregnancy in chronic hypertension.

    abstract:OBJECTIVE:To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy. METHODS:Stroke volume index (SI), heart rate (HR), cardiac output index (CI), systemic vascular resistance index (SVRI), pulse wave velocity (PWV), and left cardiac work index (LCWI) were measured using whole-bod...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701436016

    authors: Tihtonen K,Kööbi T,Huhtala H,Uotila J

    更新日期:2007-01-01 00:00:00

  • Fetal DNA quantitation in peripheral blood is not useful as a marker of disease severity in women with preeclampsia.

    abstract:OBJECTIVE:Trophoblast migration into the maternal circulation is increased in preeclampsia and can trigger the endothelial dysfunction that characterizes the clinical disease. We hypothesised that 'fetal trafficking' is increased in women with severe preeclampsia and that the quantity of trafficking is greater in women...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120021062

    authors: Byrne BM,Crowley A,Taulo F,Anthony J,O'Leary JJ,O'Herlihy C

    更新日期:2003-01-01 00:00:00

  • Subsequent pregnancy outcome after first pregnancy with normotensive early-onset intrauterine growth restriction at

    abstract:OBJECTIVE:The aim of this study was to evaluate maternal and fetal outcome of the subsequent pregnancy of primiparous women with a history of early-onset intrauterine growth restriction (IUGR), prompting delivery before 34 weeks of gestation, without concomitant maternal hypertensive disease. DESIGN:Retrospective coho...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.484080

    authors: Evers AC,van Rijn BB,van Rossum MM,Bruinse HW

    更新日期:2011-01-01 00:00:00

  • Serum adiponectin levels in normal and hypertensive pregnancy.

    abstract:OBJECTIVE:The aim of this study was to quantify adiponectin levels in women with normal and hypertensive pregnancies to determine whether there is an independent association, while controlling for body fat and insulin sensitivity. METHODS:A cross-sectional study was conducted in the following categories: 12 normotensi...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950600912976

    authors: O'Sullivan AJ,Kriketos AD,Martin A,Brown MA

    更新日期:2006-01-01 00:00:00

  • Nutritional status of women with gestational hypertension compared with normal pregnant women.

    abstract:BACKGROUND:Some evidence indicated the role of nutrition in the development of hypertensive disorders of pregnancy. METHODS:This case-control study was conducted on 113 women with gestational hypertension and 150 healthy pregnant women referred to Shahid Akbarabadi Hospital in Tehran. A demographic questionnaire was f...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2013.784782

    authors: Kazemian E,Dorosty-Motlagh AR,Sotoudeh G,Eshraghian MR,Ansary S,Omidian M

    更新日期:2013-05-01 00:00:00

  • Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia.

    abstract:OBJECTIVE:Pre-eclampsia is associated with significant maternal and neonatal complications, and delivery is often expedited to minimise complications. For randomised trials evaluating interventions in women with late-onset (>34 weeks) mild to moderate pre-eclampsia, no single outcome has been identified to be the most ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2013.837176

    authors: Fong F,Rogozinska E,Allotey J,Kempley S,Shah DK,Thangaratinam S

    更新日期:2014-05-01 00:00:00

  • Massive respiratory dysfunction as sign of fulminant peripartum cardiomyopathy (PPCM).

    abstract:OBJECTIVE:Case report of a 35-year-old gravida 3, para 2, at 40 + 6 weeks with massive respiratory dysfunction with need of oxygenation, requiring cesarean section. CASE REPORT:Postpartum investigations revealed pathological cardiomegaly with left ventricular failure (NYHAIV). Cardiac biopsy diagnosed postpartum dilat...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2012.679014

    authors: Freerksen N,Jaekel J,Menon AK,Maass N,Bauerschlag D

    更新日期:2012-01-01 00:00:00

  • MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.

    abstract:OBJECTIVE:The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS:Microarray-based study was carried out with placental samples. RESULTS:Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however,...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,评审

    doi:10.3109/10641955.2013.807819

    authors: Betoni JS,Derr K,Pahl MC,Rogers L,Muller CL,Packard RE,Carey DJ,Kuivaniemi H,Tromp G

    更新日期:2013-11-01 00:00:00

  • Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.

    abstract:OBJECTIVE:Preeclampsia and intrauterine growth retardation (IUGR) are associated with elevated concentrations of myeloperoxidase (MPO) and polymorphonuclear (PMN) elastase, which indicate maternal neutrophil activation. The aim of the study was to measure maternal MPO and PMN elastase plasma concentrations in second tr...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120024027

    authors: Stepan H,Heihoff-Klose A,Faber R

    更新日期:2003-01-01 00:00:00

  • Changes in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial.

    abstract:OBJECTIVES:The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS:131 pregnant women cons...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/10641955.2018.1446977

    authors: Babar A,Bujold E,Leblanc V,Lavoie-Lebel É,Paquette J,Bazinet L,Lemieux S,Marc I,Abdous B,Dodin S

    更新日期:2018-05-01 00:00:00

  • Hypertensive disorders in primigravid black South African women: A one-year descriptive analysis.

    abstract:OBJECTIVE:To describe the incidence and obstetric and perinatal outcomes in primigravid Black South Africans with hypertensive disorders of pregnancy (HDP). METHOD:All primigravidae who booked for antenatal care were followed up until hospital discharge. Relevant clinical and demographic data were collected in structu...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1193190

    authors: Moodley J,Onyangunga OA,Maharaj NR

    更新日期:2016-11-01 00:00:00

  • Cytokine production by monocytes, NK cells, and lymphocytes is different in preeclamptic patients as compared with normal pregnant women.

    abstract:OBJECTIVE:To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS:Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lympho...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701885006

    authors: van Nieuwenhoven AL,Moes H,Heineman MJ,Santema J,Faas MM

    更新日期:2008-01-01 00:00:00