Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats.

Abstract:

:Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female offspring. When ET was accompanied with in vitro culture in R1ECM, not only the female offspring, but also males demonstrated alleviation of hypertension. Conclusions: IVC at the preimplantation embryo stage affected the manifestation of hypertension in the adult ISIAH offspring.

journal_name

Hypertens Pregnancy

authors

Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

doi

10.1080/10641955.2019.1647232

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

208-216

issue

4

eissn

1064-1955

issn

1525-6065

journal_volume

38

pub_type

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