Abstract:
OBJECTIVE:To determine the correlation between simultaneous assessment of maternal middle cerebral blood flow velocity with the other maternal hemodynamic factors of cardiac output and mean arterial pressure. STUDY DESIGN:Eight normotensive patients were assessed. Maternal cerebral blood flow velocity was assessed using transcranial Doppler. Cardiac output was assessed noninvasively using the thoracic electrical bioimpedance technique over four cycles. Transcranial assessment of cerebral blood flow velocity was done over four cycles. Statistical analysis was then done using the Pearson correlation coefficient and linear regression analysis with stepwise regression. A p-value of < 0.05 was considered significant. RESULTS:The value of the hemodynamic parameters were cardiac output 8.6 +/- 2.6 L/min, mean arterial pressure 82 +/- 9.7 mm Hg, and mean maternal cerebral blood flow velocity 59.6 +/- 11 cm/s. The pulsatility index was 0.85 +/- 0.15. The mean blood pressure could only explain 42% of the variation in systolic maternal cerebral blood flow velocity and 32% of the variation in mean maternal cerebral blood flow velocity. The mean middle cerebral blood flow velocity did not correlate with cardiac output. CONCLUSIONS:Middle cerebral artery velocity correlates moderately with mean arterial pressure but not with cardiac output. The control of mean arterial pressure cannot be used as the only indicator of appropriate reduction in cerebral blood flow velocity.
journal_name
Hypertens Pregnancyjournal_title
Hypertension in pregnancyauthors
Williams KP,Wilson Sdoi
10.3109/10641959909016200keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
273-8issue
3eissn
1064-1955issn
1525-6065journal_volume
18pub_type
杂志文章abstract:OBJECTIVE:To compare connexin expression in omental resistance arteries from preeclamptic women and normal gravidas. METHODS:Small arteries (approximately 200-400 microm i.d.) were dissected from omental fat biopsies, taken at cesarean delivery from normotensive and preeclamptic women. Vessels were frozen and homogeni...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-100104178
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:The diagnostic value of affinity-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis to distinguish preeclampsia (PE) from matched controls was tested in a multicenter setting. METHODS:Serum samples of preeclamptic (n = 60) and healthy pregnant women (n = 66) from four...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,多中心研究
doi:10.3109/10641955.2011.640375
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine. METHODS:Blood pressure and FHT categories were assessed one hour before and after medication administration. Hy...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1117098
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To determine whether Chlamydia pneumoniae antibodies and highly sensitive C-reactive protein (hsCRP) levels in maternal sera are associated with preeclampsia or gestational hypertension. METHODS:C. pneumoniae antibodies and hsCRP levels were measured in maternal serum during first trimester (mean, 10.4 weeks...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701885188
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and associated factors of superimposed preeclampsia among pregnant women with chronic hypertension. METHODS:A total of 300 pregnant women diagnosed with chronic hypertension were reviewed. Data were retrieved from medical records, including obstetric data, characteristics of hypert...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1311340
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity. METHODS:Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography. RESULTS:Sodium nitroprusside-i...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10601330701274824
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1117099
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is synthesized in cardiac ventricles in response to volume expansion. This study evaluated NT-proBNP levels to determine the clinical correlation with the severity of hypertensive disorders complicating pregnancy. METHODS:NT-proBNP levels of 95 pregnan...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641950903115046
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to reduce the rate of cesarean section (CS) in severe pregnancy-induced hypertension (PIH) by introducing a set of indicative criteria for CS. METHODS:Labor induction was attempted in Japanese patients (n = 41) with severe PIH after 34 weeks of gestation. Vital signs and symptoms th...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1115061
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To compare fibrinogen concentration and factor VIII activity obtained from pregnant women with preeclampsia with those obtained from women with either normal pregnancies or with complications unrelated to preeclampsia. MATERIALS AND METHODS:Fibrinogen concentration and factor VIII activity were measured in t...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701548240
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the value of placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and sFlt-1/PLGF ratio, in predicting symptomatic preeclampsia (PE). METHODS:A prospective longitudinal study was carried out on 71 high risk preeclamptic women cohort. All of t...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2013.807818
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1280049
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To evaluate Protein/Creatinine ratio on random urine samples for prediction of proteinuria in preeclampsia. MATERIALS AND METHODS:This study was performed on 150 pregnant women who were hospitalized as preeclampsia in Ghaem Hospital during 2006. At first, a 24-hours urine sample was collected for each patien...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2010.507838
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To identify parameters that may assist clinicians in predicting which women will develop preeclampsia (PE) after initially presenting with gestational hypertension (GH). METHODS:118 women were recruited to the study with GH or PE. They were divided into three groups based on their diagnosis at delivery- (1) ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950601147952
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. METHODS:The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802601187
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS:Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS:The PE group had significantly lower apelin...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1777300
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Oxidative stress and a generalized inflammatory state are features of preeclampsia (PE). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with PE, and to determine the relationship between oxidative stress and inflammation in P...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802233064
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To investigate the importance of prostacyclin and nitric oxide synthesis in endothelium-dependent relaxation in myometrial resistance vessels, and to test the hypothesis that a deficiency in nitric oxide synthesis contributes to the known alterations in endothelial function in preeclampsia. METHODS:Thirty-si...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641959909009611
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To provide long-term follow-up data on women with a history of hemolysis, elevated liver enzymes, and low platelets [(H)ELLP] syndrome regarding the risk of recurrence in subsequent pregnancies and disease in later life. METHODS:All women admitted to the Academic Medical Centre between January 1984 and Janua...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-100104168
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To determine if the phosphodiesterase type 5 inhibitor sildenafil prolongs pregnancy in women with preeclampsia. METHODS:Women with preeclampsia at gestational ages 24-34 weeks were recruited from nine hospitals in the UK, and randomly assigned to sildenafil citrate or placebo. Medication was increased every...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,随机对照试验
doi:10.3109/10641950802601278
更新日期:2009-08-01 00:00:00
abstract::The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery dur...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1762894
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:There is evidence of altered vascular endothelial function in women with preeclampsia as well as in the endothelial cells from umbilical vessels of preeclamptic pregnancies. Matrix metalloproteinase (MMP)-2 is elevated in the plasma of preeclamptic women and is a mediator of vascular reactivity; however, whe...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120028281
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to quantify adiponectin levels in women with normal and hypertensive pregnancies to determine whether there is an independent association, while controlling for body fat and insulin sensitivity. METHODS:A cross-sectional study was conducted in the following categories: 12 normotensi...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950600912976
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Case report of a 35-year-old gravida 3, para 2, at 40 + 6 weeks with massive respiratory dysfunction with need of oxygenation, requiring cesarean section. CASE REPORT:Postpartum investigations revealed pathological cardiomegaly with left ventricular failure (NYHAIV). Cardiac biopsy diagnosed postpartum dilat...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2012.679014
更新日期:2012-01-01 00:00:00
abstract::Objectives: Establishment of association between: (a) Val158Met COMT (G1947A) polymorphism and preeclampsia; (b) cytokines gene expression and COMT genotypes. Methods: 50 preeclampsia and 50 healthy pregnant women were enrolled. COMT genotyping was done by PCR/RFLP. TNF-α, IL-1β, and IL-6 mRNA levels were determined b...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1843663
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:We examined whether maternal body mass index (BMI) during prepregnancy is useful for prediction of maternal preeclampsia in twin pregnancies. METHODS:We studied 250 dichorionic twin pregnancies and 3196 singleton pregnancies. Maternal BMI was calculated during prepregnancy in both twin and singleton pregnanc...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/prg-100101988
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120004767
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Trophoblast migration into the maternal circulation is increased in preeclampsia and can trigger the endothelial dysfunction that characterizes the clinical disease. We hypothesised that 'fetal trafficking' is increased in women with severe preeclampsia and that the quantity of trafficking is greater in women...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120021062
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS:Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2018.1498879
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:The aim of this 2-group, parallel, double blind single-centre RCT was to evaluate the acute and chronic impacts of high flavanol high theobromine (HFHT) chocolate consumption on endothelial function, arterial stiffness and blood pressure (BP) in women at risk of preeclampsia. METHODS:131 pregnant women cons...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章,随机对照试验
doi:10.1080/10641955.2018.1446977
更新日期:2018-05-01 00:00:00