Subsequent pregnancy outcome after first pregnancy with normotensive early-onset intrauterine growth restriction at

Abstract:

OBJECTIVE:The aim of this study was to evaluate maternal and fetal outcome of the subsequent pregnancy of primiparous women with a history of early-onset intrauterine growth restriction (IUGR), prompting delivery before 34 weeks of gestation, without concomitant maternal hypertensive disease. DESIGN:Retrospective cohort study. SETTING:Tertiary center in the Netherlands. POPULATION:Women with a normotensive first pregnancy complicated by early-onset severe IUGR, prompting delivery before 34 weeks of gestation. METHODS:Reproductive follow-up data were recorded for 22 women with a normotensive first pregnancy complicated by early-onset severe IUGR before 34 weeks, referred to the University Medical Centre Utrecht, the Netherlands, between 1993 and 2005. MAIN OUTCOME MEASURES:Main outcome measures were recurrent IUGR, perinatal mortality, preterm delivery, preeclampsia (PE), pregnancy-induced hypertension, and other major obstetric complications, for example placental abruption. RESULTS:Mean gestational age at delivery was 29.4 weeks for the index pregnancy compared to 36.4 weeks for the next pregnancy. IUGR recurred in six pregnancies (27.3%). Four subsequent pregnancies were complicated by hypertensive disorders. Perinatal mortality was 72.7% in the index pregnancy, compared to 13.6% in the second pregnancy. Overall, 11 women (54.5%) had an uneventful pregnancy. CONCLUSION:Women with first pregnancy early-onset IUGR, without concomitant maternal hypertensive disease, frequently develop severe perinatal complications in their subsequent pregnancy.

journal_name

Hypertens Pregnancy

authors

Evers AC,van Rijn BB,van Rossum MM,Bruinse HW

doi

10.3109/10641955.2010.484080

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

37-44

issue

1

eissn

1064-1955

issn

1525-6065

journal_volume

30

pub_type

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