A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia.

abstract：OBJECTIVE:To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. METHODS:The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were...

journal_title：Hypertension in pregnancy

authors： Cebesoy FB,Balat O,Dikensoy E,Kalayci H,Ibar Y

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:This study investigated endothelin-1 (ET-1) production induced by vascular endothelial growth factor (VEGF) in two different vascular wall cell types. METHODS:We analyzed the effect of endothelin-converting enzyme-1 (ECE-1) inhibitor and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) on VEGF-induce...

journal_title：Hypertension in pregnancy

authors： Seol HJ,Oh MJ,Kim HJ

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To examine the association between calcium levels during the first trimester of pregnancy and preeclampsia. METHODS:The study population included registered births (n = 5233) in a tertiary medical center between 2001 and 2011. A comparison was performed between women with and without hypocalcemia during the ...

journal_title：Hypertension in pregnancy

authors： Gabbay A,Tzur T,Weintraub AY,Shoham-Vardi I,Sergienko R,Sheiner E

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To determine the correlation between simultaneous assessment of maternal middle cerebral blood flow velocity with the other maternal hemodynamic factors of cardiac output and mean arterial pressure. STUDY DESIGN:Eight normotensive patients were assessed. Maternal cerebral blood flow velocity was assessed usi...

journal_title：Hypertension in pregnancy

authors： Williams KP,Wilson S

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:We compared second pregnancy outcomes among women with and without preeclampsia in their first pregnancies who all had second pregnancies without preeclampsia. METHODS:One hundred thirty women with and 6148 without preeclampsia in their first pregnancies, who all had nonpreeclamptic second pregnancies, were...

journal_title：Hypertension in pregnancy

authors： Lain KY,Krohn MA,Roberts JM

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the incidence of hypertensive disorders is different in monozygotic compared to dizygotic twin pregnancies. METHODS:A registry-based survey of twin pregnancies delivered during 2003 to 2012. We used the best clinical estimate of zygosity based on the concept that all monochorionic twins ...

journal_title：Hypertension in pregnancy

authors： Lučovnik M,Blickstein I,Lasič M,Fabjan-Vodušek V,Bržan-Simenc G,Verdenik I,Tul N

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Preeclampsia and intrauterine growth retardation (IUGR) are associated with elevated concentrations of myeloperoxidase (MPO) and polymorphonuclear (PMN) elastase, which indicate maternal neutrophil activation. The aim of the study was to measure maternal MPO and PMN elastase plasma concentrations in second tr...

journal_title：Hypertension in pregnancy

authors： Stepan H,Heihoff-Klose A,Faber R

更新日期：2003-01-01 00:00:00

abstract：:Preeclampsia and intrauterine growth restriction are both characterized by placental malfunction. The pathological processes of abnormal trophoblast invasion, partial absence of maternal spiral artery modification, increased apoptosis of trophoblast cells, and placental ischemia are all associated with the release of ...

journal_title：Hypertension in pregnancy

authors： Tjoa ML,Oudejans CB,van Vugt JM,Blankenstein MA,van Wijk IJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine. METHODS:Blood pressure and FHT categories were assessed one hour before and after medication administration. Hy...

journal_title：Hypertension in pregnancy

authors： Sharma KJ,Rodriguez M,Kilpatrick SJ,Greene N,Aghajanian P

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To examine the management of early-onset preeclampsia and its maternal and fetal morbidity and mortality. DESIGN:Retrospective cohort study of 49,812 births at a university teaching hospital between June 1986 and March 1997. Seventy-one women were identified with a diagnosis of preeclampsia with an onset at ...

journal_title：Hypertension in pregnancy

authors： Murphy DJ,Stirrat GM

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To assess seasonal patterns and monthly variations in the incidence of preeclampsia in the Jewish and Bedouin population in Israel, assuming that ethnicity and environmental factors may have a role in the causal mechanism. METHODS:A retrospective population-based study comparing all singleton pregnancies of ...

journal_title：Hypertension in pregnancy

authors： Shental O,Friger M,Sheiner E

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS:A prospective case-control study included a study group consisting of 30 pregnant women with p...

journal_title：Hypertension in pregnancy

authors： Milosevic-Stevanovic J,Krstic M,Radovic-Janosevic D,Stefanovic M,Antic V,Djordjevic I

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the levels of serum lipoproteins in women with pregnancy-induced hypertension and compare it with the corresponding levels in pregnant women having normal blood pressure. METHOD:This cross-sectional study was conducted in the three tertiary care hospitals of Peshawar, North West Frontier Provinc...

journal_title：Hypertension in pregnancy

authors： Jan MR,Nazli R,Shah J,Akhtar T

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Oxidative stress and a generalized inflammatory state are features of preeclampsia (PE). The objective of this study was to compare the levels of products of inflammatory reaction and oxidative stress markers in patients with PE, and to determine the relationship between oxidative stress and inflammation in P...

journal_title：Hypertension in pregnancy

authors： Ouyang YQ,Li SJ,Zhang Q,Cai HB,Chen HP

更新日期：2009-02-01 00:00:00

abstract：:The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...

journal_title：Hypertension in pregnancy

authors： Namlı Kalem M,Kalem Z,Yüce T,Soylemez F

更新日期：2018-02-01 00:00:00

abstract：:Intracranial hemorrhage and stroke are primary causes of maternal mortality in pregnancies affected by hypertensive disorders. As such antihypertensive therapy plays a crucial role in the management of severe hypertension. However, the target level to achieve the best outcome for both - mother and fetus - is still unc...

journal_title：Hypertension in pregnancy

authors： Wertaschnigg D,Wang R,Reddy M,Costa FDS,Mol BWJ,Rolnik DL

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Hypertension that develops after 20 gestational weeks and is defined as pregnancy-induced hypertension (PIH). The main cause of PIH is vasoconstriction and the thickening of vascular media, which decreases vascular capacity and increases peripheral resistance. One of the theories postulated to explain this p...

journal_title：Hypertension in pregnancy

authors： Kwiatkowski S,Kwiatkowska E,Czajka R,Ciechanowski K,Kedzierska K,Bober J,Rzepka R,Golembiewska E,Chlubek D

更新日期：2006-01-01 00:00:00

abstract：:Objective: Gestational hypertension (GH) is an important pregnancy complication. Sparse studies have shown a correlation between this complication and psychological disorders in patients. In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional stud...

journal_title：Hypertension in pregnancy

authors： Rezaei Ardani A,Tara F,Naghizadeh Kashani S,Hatami SB,Emadzadeh M,Nahidi M

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...

journal_title：Hypertension in pregnancy

authors： Xuan J,Jing Z,Yuanfang Z,Xiaoju H,Pei L,Guiyin J,Yu Z

更新日期：2016-01-01 00:00:00

abstract：:Objectives: Establishment of association between: (a) Val158Met COMT (G1947A) polymorphism and preeclampsia; (b) cytokines gene expression and COMT genotypes. Methods: 50 preeclampsia and 50 healthy pregnant women were enrolled. COMT genotyping was done by PCR/RFLP. TNF-α, IL-1β, and IL-6 mRNA levels were determined b...

journal_title：Hypertension in pregnancy

authors： Sljivancanin Jakovljevic T,Kontic-Vucinic O,Nikolic N,Carkic J,Milasin J

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To determine whether Chlamydia pneumoniae antibodies and highly sensitive C-reactive protein (hsCRP) levels in maternal sera are associated with preeclampsia or gestational hypertension. METHODS:C. pneumoniae antibodies and hsCRP levels were measured in maternal serum during first trimester (mean, 10.4 weeks...

journal_title：Hypertension in pregnancy

authors： Karinen L,Leinonen M,Bloigu A,Paldanius M,Koskela P,Saikku P,Hartikainen AL,Jarvelin MR,Pouta A

更新日期：2008-01-01 00:00:00

abstract：:Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female...

journal_title：Hypertension in pregnancy

authors： Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To characterize the maternal and fetal presentation of abruptio placentae and associated maternal and fetal morbidity and mortality by mode of delivery and fetal status on admission. STUDY DESIGN:Perinatal data (gestational age > 24 weeks) from women with abruptio placentae at a tertiary referral center were...

journal_title：Hypertension in pregnancy

authors： Witlin AG,Sibai BM

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...

journal_title：Hypertension in pregnancy

authors： Maymon R,Trahtenherts A,Svirsky R,Melcer Y,Madar-Shapiro L,Klog E,Meiri H,Cuckle H

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:We examined whether maternal body mass index (BMI) during prepregnancy is useful for prediction of maternal preeclampsia in twin pregnancies. METHODS:We studied 250 dichorionic twin pregnancies and 3196 singleton pregnancies. Maternal BMI was calculated during prepregnancy in both twin and singleton pregnanc...

journal_title：Hypertension in pregnancy

authors： Suzuki S,Yoneyama Y,Sawa R,Shin S,Araki T

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To compare fibrinogen concentration and factor VIII activity obtained from pregnant women with preeclampsia with those obtained from women with either normal pregnancies or with complications unrelated to preeclampsia. MATERIALS AND METHODS:Fibrinogen concentration and factor VIII activity were measured in t...

journal_title：Hypertension in pregnancy

authors： Williams VK,Griffiths AB,Carbone S,Hague WM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There is evidence of altered vascular endothelial function in women with preeclampsia as well as in the endothelial cells from umbilical vessels of preeclamptic pregnancies. Matrix metalloproteinase (MMP)-2 is elevated in the plasma of preeclamptic women and is a mediator of vascular reactivity; however, whe...

journal_title：Hypertension in pregnancy

authors： Merchant SJ,Narumiya H,Zhang Y,Guilbert LJ,Davidge ST

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to reduce the rate of cesarean section (CS) in severe pregnancy-induced hypertension (PIH) by introducing a set of indicative criteria for CS. METHODS:Labor induction was attempted in Japanese patients (n = 41) with severe PIH after 34 weeks of gestation. Vital signs and symptoms th...

journal_title：Hypertension in pregnancy

authors： Shibata T,Nakago S,Kato H,Tokuda H,Matsuki R,Kotsuji F

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To describe the incidence and obstetric and perinatal outcomes in primigravid Black South Africans with hypertensive disorders of pregnancy (HDP). METHOD:All primigravidae who booked for antenatal care were followed up until hospital discharge. Relevant clinical and demographic data were collected in structu...

journal_title：Hypertension in pregnancy

authors： Moodley J,Onyangunga OA,Maharaj NR

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To determine whether the higher rate of preeclampsia previously reported in Black women is attributable to a higher rate of chronic hypertension in that group. METHODS:Rates and severity of pregnancy-related hypertensive disease in Black and White women with and without chronic hypertension were reviewed fro...

journal_title：Hypertension in pregnancy

authors： Bryant AS,Seely EW,Cohen A,Lieberman E

更新日期：2005-01-01 00:00:00