Endothelin-1 expression by vascular endothelial growth factor in human umbilical vein endothelial cells and aortic smooth muscle cells.

Abstract:

OBJECTIVE:This study investigated endothelin-1 (ET-1) production induced by vascular endothelial growth factor (VEGF) in two different vascular wall cell types. METHODS:We analyzed the effect of endothelin-converting enzyme-1 (ECE-1) inhibitor and tissue inhibitors of matrix metalloproteinase-2 (TIMP-2) on VEGF-induced ET-1 expression using real-time polymerase chain reaction and enzyme-linked immunosorbent assay in human umbilical vein endothelial cells and aortic smooth muscle cells. RESULTS:In human umbilical vein endothelial cells, both phosphoramidon, an inhibitor of ECE-1, and TIMP-2 decreased VEGF-induced ET-1 production. In aortic smooth muscle cells, TIMP-2 suppressed VEGF-induced ET-1 production, but phosphoramidon did not influence ET-1 concentration in culture. CONCLUSION:VEGF-induced ET-1 production may be MMP-2- or ECE-1-dependant in endothelial cells; however, in smooth muscle cells, ET-1 expression appears to be induced by MMP-2 only.

journal_name

Hypertens Pregnancy

authors

Seol HJ,Oh MJ,Kim HJ

doi

10.3109/10641950903115053

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

295-301

issue

3

eissn

1064-1955

issn

1525-6065

journal_volume

30

pub_type

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    abstract:OBJECTIVES:To evaluate the levels of serum lipoproteins in women with pregnancy-induced hypertension and compare it with the corresponding levels in pregnant women having normal blood pressure. METHOD:This cross-sectional study was conducted in the three tertiary care hospitals of Peshawar, North West Frontier Provinc...

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    authors: Jan MR,Nazli R,Shah J,Akhtar T

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  • The effect of mode of delivery on placental chorionic plate vascular reactivity.

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    authors: Mills TA,Baker PN,Wareing M

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  • Patterns of pregnancy-related hypertension in black and white women.

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  • Treatment of severe hypertension during pregnancy: we still do not know what the best option is.

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    更新日期:2020-02-01 00:00:00

  • Closure versus non-closure of the visceral peritoneum (VP) in patients with gestational hypertension--an observational analysis.

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    更新日期:2009-01-01 00:00:00

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  • Second pregnancy outcomes following preeclampsia in a first pregnancy.

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  • Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia.

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  • MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.

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  • Subsequent pregnancy outcome after first pregnancy with normotensive early-onset intrauterine growth restriction at

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    authors: Evers AC,van Rijn BB,van Rossum MM,Bruinse HW

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  • Preeclampsia with and without intrauterine growth restriction-Two pathogenetically different entities?

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    authors: Milosevic-Stevanovic J,Krstic M,Radovic-Janosevic D,Stefanovic M,Antic V,Djordjevic I

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  • Interactions between inflammatory and oxidative stress in preeclampsia.

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  • Feto-maternal correlation of PTX3, sFlt-1 and PlGF in physiological and pre-eclamptic pregnancies.

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    doi:10.3109/10641955.2014.903962

    authors: Algeri P,Ornaghi S,Bernasconi DP,Cappellini F,Signorini S,Brambilla P,Urban G,Vergani P

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  • Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies.

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  • Fibrinolysis parameters in Sudanese women with severe preeclampsia.

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  • Predicting transformation from gestational hypertension to preeclampsia in clinical practice: a possible role for 24 hour ambulatory blood pressure monitoring.

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    pub_type: 杂志文章,随机对照试验

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    doi:10.1080/10641955.2016.1258411

    authors: Lin LT,Hu LY,Tang PL,Tsui KH,Cheng JT,Huang WC,Chang HT

    更新日期:2017-05-01 00:00:00

  • Management of severe pregnancy-induced hypertension after 34 weeks of gestation: A prospective study to reduce the rate of cesarean section.

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    authors: Shibata T,Nakago S,Kato H,Tokuda H,Matsuki R,Kotsuji F

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    pub_type: 杂志文章

    doi:10.1081/PRG-120004767

    authors: Livingston JC,Ahokas R,Haddad B,Sibai BM,Awaads R

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    pub_type: 杂志文章

    doi:10.1080/10641955.2019.1647232

    authors: Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

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    authors: Brown MC,Bell R,Collins C,Waring G,Robson SC,Waugh J,Finch T

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