Abstract:
AIM:This study investigated the effect of aminophylline on behaviour and autonomic function in the preterm period. METHOD:Subjects were preterm infants cared for in the Oita University hospital from August 2012 to October 2014. The group that was administered aminophylline (Am+) and the group that received no aminophylline (Am-) included 11 cases that exhibited a mean gestational age of 28weeks 5days and a mean birth weight of 1109g and 8 cases that exhibited a mean gestational age of 30weeks 5days and a mean birth weight of 1223g, respectively. Intravenous aminophylline was administered continuously at a dose of 4-6mg/kg/day followed by oral therapy when the infant suffered repetitive apnoea. Two-hour video recordings were obtained every 2weeks, and electrocardiograms were performed simultaneously. Onset-offset and tremulous movements in general movement (GM) optimality list were used as indices of behaviour. Autonomic functions were investigated via heart-rate and heart-rate variability measurements using frequency domain spectral analysis and the MemCalc method. We compared indices in 4 periods: 30-31, 32-33, 34-35 and 36-37weeks gestation. RESULTS:The Am+ group exhibited significantly low optimality of tremulous movements at 32-33weeks gestation. The autonomic parameters did not differ significantly between the Am+ and Am- groups. There was no significant correlation between GMs optimality score and serum theophylline concentration. CONCLUSION:Aminophylline administration was associated with transient irritable behaviour without autonomic changes in the preterm period.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
Maeda T,Inoue M,Sekiguchi K,Ihara Kdoi
10.1016/j.earlhumdev.2016.04.011subject
Has Abstractpub_date
2016-08-01 00:00:00pages
37-41eissn
0378-3782issn
1872-6232pii
S0378-3782(15)30149-3journal_volume
99pub_type
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journal_title:Early human development
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2014.01.006
更新日期:2014-03-01 00:00:00
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journal_title:Early human development
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journal_title:Early human development
pub_type: 杂志文章
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pub_type: 杂志文章,实务指引,评审
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journal_title:Early human development
pub_type: 杂志文章,多中心研究
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更新日期:2017-12-01 00:00:00
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journal_title:Early human development
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pub_type: 杂志文章,评审
doi:10.1016/j.earlhumdev.2008.09.004
更新日期:2008-12-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1988-03-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2011.09.013
更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2012.01.005
更新日期:2012-08-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章
doi:10.1016/j.earlhumdev.2016.01.002
更新日期:2016-03-01 00:00:00
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journal_title:Early human development
pub_type: 杂志文章,多中心研究
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更新日期:2012-01-01 00:00:00