Abstract：
BACKGROUND:Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm. AIM:To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m2) and obese (i.e., BMI≥30kg/m2) women relative to the risk among children born to women who were neither overweight nor obese (i.e. BMI<25kg/m2). STUDY DESIGN:Multi-center prospective cohort study. METHODS:A total of 764 children born before the 28th week of gestation and whose mother's pre-pregnancy height and pre-pregnancy weight were obtained at birth had an IQ≥70 at age 10years when parents and teachers completed Child Symptom Inventory-4 questionnaires that included items about the presence of ADHD. RESULTS:Compared to children whose mother's pre-pregnancy weight was in the normal range (BMI<25kg/m2), children were at increased risk of parent-identified ADHD behaviors if their mother was overweight (odds ratio (OR)=1.9; 95% confidence interval (CI): 1.1, 3.3), or obese (OR=2.3; 95% CI: 1.4, 3.9). They were not at increased risk of teacher-identified ADHD characteristics if their mother was overweight before her pregnancy (OR=1.0; 95% CI: 0.6, 1.8), or obese (OR=1.0; 95% CI: 0.6, 1.6). CONCLUSION:Maternal overweight and obesity are associated with increased risk of parent-identified ADHD characteristics at 10years of age in children born extremely preterm.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
van der Burg JW,Jensen ET,van de Bor M,Joseph RM,O'Shea TM,Kuban K,Allred EN,Scott M,Hunter S,Hooper SR,Dammann O,Leviton Adoi
10.1016/j.earlhumdev.2017.08.002subject
Has Abstractpub_date
2017-12-01 00:00:00pages
9-15eissn
0378-3782issn
1872-6232pii
S0378-3782(16)30296-1journal_volume
115pub_type
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