Abstract：
INTRODUCTION:Many women with a bipolar disorder are of reproductive age and will need to continue lithium treatment during pregnancy. The teratogenic and perinatal effects of lithium are known, but not the long-term effects of lithium on neurodevelopment of the children. This study investigates growth, neurological, cognitive and behavioral development of children exposed to lithium in utero. METHOD:In an observational retrospective cohort study 15 children who were exposed to lithium in utero were investigated at 3-15 years of age. Neurological development was tested using the Hempel or Touwen examination. Cognitive development was assessed with the Bayley Scales of Infant Development III, Wechsler Preschool and Primary Scale of Intelligence or the Wechsler Intelligence Scale for Children. Parents completed the Child Behavior Checklist to assess behavioral development and a standard questionnaire about general development of the child since birth. RESULTS:One child had signs of a minor neurological dysfunction, but without further clinical implications. The results of the cognitive tests were within normal limits, although most children had lower scores on the performance IQ subtest. Growth, behavior and general development were within the normal range. CONCLUSIONS:Continuing lithium therapy during pregnancy did not cause adverse effects on growth, neurological, cognitive and behavioral development of exposed children.
journal_name
Early Hum Devjournal_title
Early human developmentauthors
van der Lugt NM,van de Maat JS,van Kamp IL,Knoppert-van der Klein EA,Hovens JG,Walther FJdoi
10.1016/j.earlhumdev.2011.09.013subject
Has Abstractpub_date
2012-06-01 00:00:00pages
375-8issue
6eissn
0378-3782issn
1872-6232pii
S0378-3782(11)00322-7journal_volume
88pub_type
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pub_type： 杂志文章,评审
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