Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs.

abstract：:The effect of changes in muscle length on post-tetanic isometric twitch tension potentiation and myosin P-light chain phosphorylation was studied at 23 degrees C in the mouse extensor digitorum longus muscle. The length-tension relationship was determined for the same muscles after a 30 min period of quiescence and be...

journal_title：Journal of cellular physiology

authors： Moore RL,Persechini A

更新日期：1990-05-01 00:00:00

abstract：:Methionine dependence is a metabolic defect found thus far only in transformed and malignant cells. The defect is manifested as the inability of cells to grow in media in which methionine (Met) is replaced by its immediate precursor homocysteine (Hcy). We have termed this Met- Hcy+ media. We demonstrate here that meth...

journal_title：Journal of cellular physiology

authors： Stern PH,Wallace CD,Hoffman RM

更新日期：1984-04-01 00:00:00

abstract：:Heparan sulfate from the surface of a variety of mouse cells at different cell densities was examined by ion-exchange chromatography. The results of this analysis show that: (1) The heparan sulfate from new isolates of Swiss 3T3 cells transformed by SV40 virus (a DNA tumor virus) elutes from DEAE-cellulose at a lower ...

journal_title：Journal of cellular physiology

authors： Underhill CB,Keller JM

更新日期：1977-01-01 00:00:00

abstract：:Past work has shown that delta-opioid receptor (DOR) activation by [D-Ala(2),D-Leu(5)]-enkephalin (DADLE) attenuated the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation (OGD) in the cortex, while naltrindole, a DOR antagonist blocked this effect, suggesting that DOR activity stabilizes ...

journal_title：Journal of cellular physiology

authors： Chao D,Bazzy-Asaad A,Balboni G,Xia Y

更新日期：2007-07-01 00:00:00

abstract：:Cytoplasmic poly-A containing RNA, synthesized by cultured chick embryo cells, was examined during growth in 5-bromodeoxyuridine. The kinetics of 3H-adenosine incorporation into this species of RNA, when compared to the rest of the cytoplasmic RNA, and to control cells, indicates that the rate of synthesis of this RNA...

journal_title：Journal of cellular physiology

authors： Pawlowski PJ

更新日期：1976-09-01 00:00:00

abstract：:A separation procedure has been developed for mouse splenic T and B lymphocytes which is based on their differential agglutination by wheat germ agglutinin (WGA). In the presence of 50-100 micrograms/ml of WGA, multicellular aggregates are formed which are enriched in B cells. These aggregates can be separated from mo...

journal_title：Journal of cellular physiology

authors： Bourguignon LY,Rader RL,McMahon JT

更新日期：1979-04-01 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) has been shown to occur by ligand-dependent and ligand-independent mechanisms. Different molecular mechanisms have been found to be responsible for ligand-independent receptor transactivation. Here, we show that hyperosmolar concentrations of sorbitol activate ...

journal_title：Journal of cellular physiology

authors： Cheng H,Kartenbeck J,Kabsch K,Mao X,Marqués M,Alonso A

更新日期：2002-08-01 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00

abstract：:During wound healing, myofibroblasts play a central role in matrix formation and wound contraction. At the end of healing, there is evidence that myofibroblasts disappear via apoptotic pathways. Hypertrophic scars are a fibroproliferative disorder that leads to considerable morbidity. It has been postulated that a def...

journal_title：Journal of cellular physiology

authors： Moulin V,Larochelle S,Langlois C,Thibault I,Lopez-Vallé CA,Roy M

更新日期：2004-03-01 00:00:00

abstract：:Epithelial Cell Adhesion Molecule (EpCAM), or CD326, is a trans-membrane glycoprotein expressed by multiple normal epithelia as well as carcinoma. Human hepatic stem cells and bile duct epithelium of the liver are EpCAM positive. In tumor cell lines, its intracellular domain can be released after cleavage of the extra...

journal_title：Journal of cellular physiology

authors： Gerlach JC,Foka HG,Thompson RL,Gridelli B,Schmelzer E

更新日期：2018-06-01 00:00:00

abstract：:Carbonic anhydrase (CAH) was localized in the mitochondria-rich cells (MRC) of 1-week-old salamander larvae gill epithelium, in both MRC and pavement cells of 6-week-old larvae, and in regenerated stems of previously amputated gills. CAH activity of the MRC was measured quantitatively using a microscope densitometric ...

journal_title：Journal of cellular physiology

authors： Lewinson D,Rosenberg M,Goldenberg S,Warburg MR

更新日期：1987-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to the tyrosine kinase receptors Flt-1 and Flk-1. Yet, their relative importance for hypoxia-induced hyperpermeability is ...

journal_title：Journal of cellular physiology

authors： Vogel C,Bauer A,Wiesnet M,Preissner KT,Schaper W,Marti HH,Fischer S

更新日期：2007-07-01 00:00:00

abstract：:The progression of T-lymphoma cells (CCRF-CEM) growing in suspension has been monitored during long term (12-28 h) batch experiments using microcalorimetry. In parallel with the calorimetric measurements, changes in cell concentration, pH, p(O2) and concentrations of the main energy sources (glucose and glutamine) wer...

journal_title：Journal of cellular physiology

authors： Bäckman P,Kimura T,Schön A,Wadsö I

更新日期：1992-01-01 00:00:00

abstract：:To evaluate the effects of fatty acids on endoplasmic reticulum (ER) stress, oxidative stress, and lipid damage. We treated BRL3A rat liver cells with, linoleic (LA), linolenic, oleic (OA), palmitic (PA), palmitoleic (POA), or stearic (SA) acid for 12 hr. The characteristics of cell lipid deposition, oxidative stress ...

journal_title：Journal of cellular physiology

authors： Yang W,Liu R,Xia C,Chen Y,Dong Z,Huang B,Li R,Li M,Xu C

更新日期：2020-09-01 00:00:00

abstract：:Over the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cogn...

journal_title：Journal of cellular physiology

authors： Farzaei MH,Bahramsoltani R,Abbasabadi Z,Braidy N,Nabavi SM

更新日期：2019-03-01 00:00:00

abstract：:Liver regeneration involves not only hepatocyte replication but progenitor aggregation and scarring. Partial hepatectomy (PH), an established model for liver regeneration, reactivates transforming growth factor-β (TGF-β) signaling. Hepatic stellate cells (HSCs) are primarily responding cells for TGF-β and resident in ...

journal_title：Journal of cellular physiology

authors： Chen Z,Wan L,Jin X,Wang W,Li D

更新日期：2020-03-01 00:00:00

abstract：:The addition of anti-laminin IgG to the basal surfaces of rat Sertoli cells in culture in a two-chambered assembly results in a perturbation of F-actin arrangements, including disruption of the pericellular circumferal rings, impairments of the Sertoli cell permeability barrier, and subsequently focal defoliation, fol...

journal_title：Journal of cellular physiology

authors： Tung PS,Fritz IB

更新日期：1993-07-01 00:00:00

abstract：:To evaluate the regulation of endothelial cell Cu,Zn-SOD, we have exposed bovine pulmonary artery endothelial cells in culture to hyperoxia and hypoxia, second messengers or related agonists, hormones, free radical generating systems, endotoxin, and cytokines and have measured Cu,Zn-SOD protein of these cells by an EL...

journal_title：Journal of cellular physiology

authors： Kong XJ,Fanburg BL

更新日期：1992-12-01 00:00:00

abstract：:Circular RNAs (circRNAs) have been associated with lung cancer (LC), one of the most common cancers, but the underlying molecular mechanisms of the specific correlation with LC carcinogenesis remain unveiled. Quantitative real-time polymerase chain reaction was applied to examine the level of circZNF609. LC cells were...

journal_title：Journal of cellular physiology

authors： Liu S,Yang N,Jiang X,Wang J,Dong J,Gao Y

更新日期：2021-01-01 00:00:00

abstract：:Among 14 peripheral blood samples obtained from patients affected by B chronic lymphocytic leukemia (B-CLL) at initial stages (Rai 0-1) of the disease, 6 showed intermediate/high levels of Zap-70 while 8 displayed low/absent levels of Zap-70. Although Zap-70(high) and Zap-70(low) B-CLL samples displayed similar levels...

journal_title：Journal of cellular physiology

authors： Secchiero P,di Iasio MG,Gonelli A,Barbarotto E,Melloni E,Tiribelli M,Chiaruttini C,Zauli G

更新日期：2007-10-01 00:00:00

abstract：:The effects of src oncogene expression on epidermal growth factor (EGF) receptors have been investigated in mouse 3T3 and rat-1 fibroblasts. Transformation of both cell types with src resulted in marked reductions in cellular EGF receptor levels, as assayed by either 125I-EGF binding or immunoprecipitation of receptor...

journal_title：Journal of cellular physiology

authors： Wasilenko WJ,Shawver LK,Weber MJ

更新日期：1987-06-01 00:00:00

abstract：:Estrogen-responsive genes often have an estrogen response element (ERE) positioned next to activator protein-1 (AP-1) binding sites. Considering that the interaction between ERE and AP-1 elements has been described for the modulation of bone-specific genes, we investigated the 17-beta-estradiol responsiveness and the ...

journal_title：Journal of cellular physiology

authors： Lambertini E,Tavanti E,Torreggiani E,Penolazzi L,Gambari R,Piva R

更新日期：2008-07-01 00:00:00

abstract：:In this study, we used a bioinformatics approach to analyze the nucleotide composition and pattern of synonymous codon usage in mitochondrial ND genes in three amphibian groups, that is, orders Anura, Caudata, and Gymnophiona to identify the commonality and the differences of codon usage as no research work was report...

journal_title：Journal of cellular physiology

authors： Barbhuiya PA,Uddin A,Chakraborty S

更新日期：2020-09-22 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT), via activation of Wnt signaling, is prevailing in embryogenesis, but postnatally it only occurs in pathological processes, such as in tissue fibrosis and tumor metastasis. Our prior studies led us to speculate that EMT might be involved in the loss of limbal epithelial stem cel...

journal_title：Journal of cellular physiology

authors： Kawakita T,Espana EM,Higa K,Kato N,Li W,Tseng SC

更新日期：2013-01-01 00:00:00

abstract：:The 10th annual meeting of the Italian Society for Virology (SIV) comprised seven plenary sessions focused on: General virology and viral genetics; Virus-Host interaction and pathogenesis; Viral oncology; Emerging viruses and zoonotic, foodborne and environmental pathways of transmission; Viral immunology and vaccines...

journal_title：Journal of cellular physiology

authors： Salata C,Calistri A,Parolin C,Palù G

更新日期：2012-07-01 00:00:00

abstract：:We investigated the role of mammalian target of rapamycin/nuclear factor-kappa B (mTOR/NF-κB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia-reperfusion (I/R) injury in rats. The rat model of myocardial I/R injury was established. Ninety rats were divided into the normal, sha...

journal_title：Journal of cellular physiology

authors： Huang WQ,Wen JL,Lin RQ,Wei P,Huang F

更新日期：2018-09-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been widely exploited for the treatment of several conditions due to their intrinsic regenerative and immunomodulatory properties. MSC have demonstrated to be particularly relevant for the treatment of ischemic diseases, where MSC-based therapies can stimulate angiogenesis and ind...

journal_title：Journal of cellular physiology

authors： Pinto DS,Ahsan T,Serra J,Fernandes-Platzgummer A,Cabral JMS,da Silva CL

更新日期：2020-10-01 00:00:00

abstract：:The stroma-vascular fraction (SVF) of human adipose tissue has recently been described to be composed of endothelial cells identified as CD34+/CD31+ cells, infiltrated/resident macrophages defined as CD14+/CD31+ cells, and a new cell population characterized as CD34+/CD31- cells. To elucidate the cell identity of the ...

journal_title：Journal of cellular physiology

authors： Sengenès C,Lolmède K,Zakaroff-Girard A,Busse R,Bouloumié A

更新日期：2005-10-01 00:00:00

abstract：:The effect of cell culture age and concomitant changes in cell density on the biosynthesis of sulfated-proteoglycan by rabbit articular chondrocytes in secondary monolayer culture was studied. Low density (LD, 2 d), middle density (MD, 5-7 d), and high density (HD, 12-15 d) cultures demonstrated changes in cellular mo...

journal_title：Journal of cellular physiology

authors： Malemud CJ,Papay RS

更新日期：1984-12-01 00:00:00

abstract：:Hair follicle stem cells (HFSCs) are able to differentiate into neurons and glial cells. Distinct microRNAs (miRNAs) regulate the proliferation and differentiation of HFSCs. However, the exact role of miR-124 in the neural differentiation of HFSCs has not been elucidated. HFSCs were isolated from mouse whisker follicl...

journal_title：Journal of cellular physiology

authors： Mokabber H,Najafzadeh N,Mohammadzadeh Vardin M

更新日期：2019-06-01 00:00:00