Epithelial cell adhesion molecule fragments and signaling in primary human liver cells.

abstract：:Bone marrow mesenchymal stem cells (BMSC) can ameliorate ischemic injury of various tissues. However, the molecular mechanisms involved remain to be clarified. In this study, we intend to investigate the effects of BMSC-derived conditioned medium (BMSC-CM) on hypoxia/reoxygenation (H/R)-induced injury of H9c2 myocardi...

journal_title：Journal of cellular physiology

authors： Li X,Xie X,Yu Z,Chen Y,Qu G,Yu H,Luo B,Lei Y,Li Y

更新日期：2019-08-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2) catalyzes deacetylation of histones at the promoter and coding regions of transcribed genes and regulates chromatin structure and transcription. To explore the role of HDAC2 and phosphorylated HDAC2 in gene regulation, we studied the location along transcribed genes, the mode of recruitme...

journal_title：Journal of cellular physiology

authors： Jahan S,Sun JM,He S,Davie JR

更新日期：2018-02-01 00:00:00

abstract：:The development of atherosclerotic plaque is associated with neovascularization in the thickened intima and media of vascular walls. Neovascularization may have a role in the progression of atherosclerotic plaque as well as in the development of intraplaque hemorrhage. However, the mechanism and stimulus for neovascul...

journal_title：Journal of cellular physiology

authors： Kuzuya M,Satake S,Esaki T,Yamada K,Hayashi T,Naito M,Asai K,Iguchi A

更新日期：1995-09-01 00:00:00

abstract：:Sterol regulatory element binding protein 1 (SREBP-1) is well-known as the master regulator of lipogenesis in rodents. Acyl-CoA synthetase short-chain family member 2 (ACSS2) plays a key role in lipogenesis by synthesizing acetyl-CoA from acetate for lipogenesis. ATP citrate lyase (ACLY) catalyzes the conversion of ci...

journal_title：Journal of cellular physiology

authors： Xu H,Luo J,Ma G,Zhang X,Yao D,Li M,Loor JJ

更新日期：2018-02-01 00:00:00

abstract：:We report here that heptanol (3.5 mM) induces in vitro a rapid formation of smooth endoplasmic reticulum aggregates (SERA) within isolated islets of Langerhans. SERA appeared after only 15 min of exposure to the alkanol and increased in number during the first 30 min of incubation. At that time, SERA represented 2% an...

journal_title：Journal of cellular physiology

authors： Knodel S,Meda P,Orci L

更新日期：1987-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) is a small molecule (19-25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. However, the ...

journal_title：Journal of cellular physiology

authors： Chen HP,Wen J,Tan SR,Kang LM,Zhu GC

更新日期：2019-12-01 00:00:00

abstract：:Cerebroside sulfotransferase (EC 2.8.2.11, CST) specific activity has been determined in oligodendrocyte (OL)-enriched glial cell cultures from newborn rat brain grown in serum supplemented medium. This activity is detectable at 5 days in vitro (DIV) and reaches its maximum value at 12 DIV. This period corresponds to ...

journal_title：Journal of cellular physiology

authors： Fressinaud C,Sarliève LL,Labourdette G

更新日期：1989-12-01 00:00:00

abstract：:Phenotypically different osteoclasts may be generated from different subsets of precursors. To what extent the formation of these osteoclasts is influenced or mediated by the inflammatory cytokine TNF-α, is unknown and was investigated in this study. The osteoclast precursors early blasts (CD31hi Ly-6C- ), myeloid bla...

journal_title：Journal of cellular physiology

authors： Cao Y,Jansen IDC,Sprangers S,de Vries TJ,Everts V

更新日期：2017-12-01 00:00:00

abstract：:The interaction between dietary lectins, especially wheat germ agglutinin (WGA), and intestinal cells has been implicated in the pathogenesis of celiac disease. The present study was undertaken to investigate the immediate effects following such an interaction. Direct WGA-stimulation of Intestine 407 cells leads to an...

journal_title：Journal of cellular physiology

authors： Sjölander A

更新日期：1988-03-01 00:00:00

abstract：:Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

journal_title：Journal of cellular physiology

authors： Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

更新日期：1994-12-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common, malignant, and deadly primary glioma. Six-transmembrane epithelial antigen of prostate (STEAP) family is involved in tumorigenesis; here, we have explored the biological function and the prognostic value of the STEAP family in GBM. Differentially expressed STEAP genes in tumor an...

journal_title：Journal of cellular physiology

authors： Chen H,Xu C,Yu Q,Zhong C,Peng Y,Chen J,Chen G

更新日期：2020-09-23 00:00:00

abstract：:This study aimed at investigating the expression and function of uracil nucleotide-sensitive receptors (P2Y(2), P2Y(4), and P2Y(6)) on osteogenic differentiation of human bone marrow stromal cells (BMSCs) in culture. Bone marrow specimens were obtained from postmenopausal female patients (68 ± 5 years old, n = 18) und...

journal_title：Journal of cellular physiology

authors： Noronha-Matos JB,Costa MA,Magalhães-Cardoso MT,Ferreirinha F,Pelletier J,Freitas R,Neves JM,Sévigny J,Correia-de-Sá P

更新日期：2012-06-01 00:00:00

abstract：:The opossum kidney (OK) cell was used as a model to test the hypothesis that estrogen directly affects proximal renal tubular epithelial cells. To demonstrate the expression of estrogen receptor in OK cells, we developed an approach using reverse transcription and the polymerase chain reaction. Analysis of the DNA amp...

journal_title：Journal of cellular physiology

authors： Stock JL,Coderre JA,Burke EM,Danner DB,Chipman SD,Shapiro JR

更新日期：1992-03-01 00:00:00

abstract：:The vascular isoform of ATP-sensitive K(+) (KATP ) channels regulates blood flow to all organs. The KATP channel is strongly inhibited by reactive oxygen and carbonyl species produced in diabetic tissue inflammation. To address how such channel inhibition impacts vascular regulation as well as tissue viability, we per...

journal_title：Journal of cellular physiology

authors： Li SS,Cui N,Yang Y,Trower TC,Wei YM,Wu Y,Zhang S,Jin X,Jiang C

更新日期：2015-12-01 00:00:00

abstract：:Although prostate carcinoma is an aggressive cancer preferentially metastasizing to the bones, many prostate tumors remain localized and confined to the prostate indefinitely. Prediction of the behavior of anatomically localized and moderately differentiated prostate tumors remains difficult because of lack of prognos...

journal_title：Journal of cellular physiology

authors： de Amicis F,Lanzino M,Kisslinger A,Calì G,Chieffi P,Andò S,Mancini FP,Tramontano D

更新日期：2006-10-01 00:00:00

abstract：:Selective spermatozoa movement from storage of the oviduct to fertilization site is suggested to be a result of chemotaxis. In the present study, Natriuretic peptide precursor A (NPPA) induced sperm chemotaxis in capillaries and enhanced intracellular Ca(2+) level, both of which could be blocked by the Natriuretic Pep...

journal_title：Journal of cellular physiology

authors： Bian F,Mao G,Guo M,Mao G,Wang J,Li J,Han Y,Chen X,Zhang M,Xia G

更新日期：2012-05-01 00:00:00

abstract：:Interleukin-10 (IL-10) has been shown to exert anti-inflammatory effects by suppressing macrophage proliferation and inhibiting cytokine production. In this study we show that in the presence of erythropoietin (EPO), the addition of IL-10 results in a significant dose-dependent increase in both Burst Forming Unit-Eryt...

journal_title：Journal of cellular physiology

authors： Wang CQ,Udupa KB,Lipschitz DA

更新日期：1996-02-01 00:00:00

abstract：:The role of mitochondrial dysfunction and its molecular mechanism in inflammation-induced acute liver failure (ALF) remain unknown. Despite the numerous studies performed to date, very few therapies are available for inflammation-induced ALF. Therefore, our study is aimed to explore the regulatory effects of mitochond...

journal_title：Journal of cellular physiology

authors： Song J,Lu C,Zhao W,Shao X

更新日期：2019-11-01 00:00:00

abstract：:We have previously shown that extracellular ATP acts as a mitogen via protein kinase C (PKC)-dependent and independent pathways (Wang, D., Huang, N., Gonzalez, F.A., and Heppel, L.A. Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells. I. Involvement of protein kin...

journal_title：Journal of cellular physiology

authors： Huang NN,Wang DJ,Gonzalez F,Heppel LA

更新日期：1991-03-01 00:00:00

abstract：:Priapism, a prolonged penile erection in the absence of sexual arousal, is common among patients with sickle cell disease (SCD). Hypogonadism is also common in patients with SCD. While the administration of exogenous testosterone reverses hypogonadism, it is contraceptive. We hypothesized that the stimulation of endog...

journal_title：Journal of cellular physiology

authors： Musicki B,Karakus S,La Favor JD,Chen H,Silva FH,Sturny M,Zirkin BR,Burnett AL

更新日期：2020-09-24 00:00:00

abstract：:Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily. We have reported that it has a homophilic binding activity, which participates in the neurite extension from embryonic neurons. To elucidate how gicerin is involved in the neurite extension mechanism, we employed PC12 cell...

journal_title：Journal of cellular physiology

authors： Taira E,Kohama K,Tsukamoto Y,Okumura S,Miki N

更新日期：2005-08-01 00:00:00

abstract：:The human polyomavirus, JC virus (JCV), provides an excellent model system to investigate the reciprocal interaction of the immune and nervous systems. Infection with JCV occurs during childhood and the virus remains in the latent state with no apparent clinical symptoms. However, under immunosuppressed conditions, th...

journal_title：Journal of cellular physiology

authors： Sweet TM,Del Valle L,Khalili K

更新日期：2002-06-01 00:00:00

abstract：:Differentiated embryo chondrocyte 1 (DEC1), a member of basic-helix-loop-helix transcription factor Bhlhe40, also called stimulated by retinoic acid 13, STRA13, plays an important role in the regulation of adipogenesis, tumorigenesis, peripheral circadian output, response to hypoxia, and development of metabolic syndr...

journal_title：Journal of cellular physiology

authors： Huang Y,Lai X,Hu L,Lei C,Lan X,Zhang C,Ma Y,Zheng L,Bai YY,Lin F,Chen H

更新日期：2018-12-01 00:00:00

abstract：:Tumor cells secrete extracellular vesicles (EVs) for intercellular communication. EVs by transporting different proteins, nucleic acids, and lipids contribute to affect target cell function and fate. ‎EVs which originate directly from multivesicular bodies so-called exosomes have dramatically fascinated the attention ...

journal_title：Journal of cellular physiology

authors： Jabbari N,Akbariazar E,Feqhhi M,Rahbarghazi R,Rezaie J

更新日期：2020-10-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin 4 (PCSK4) is implicated for sperm fertilizing ability, based on studies using Pcsk4-null mice. Herein we demonstrated proprotein convertase (PC) activity in intact sperm and acrosomal vesicles. To determine whether this activity was important for sperm fertilizing ability, a pept...

journal_title：Journal of cellular physiology

authors： Iamsaard S,Vanichviriyakit R,Hommalai G,Saewu A,Srakaew N,Withyachumnarnkul B,Basak A,Tanphaichitr N

更新日期：2011-11-01 00:00:00

abstract：:Epithelial cells of the airways can, under pathological conditions, undergo squamous metaplasia. The accumulation of cholesterol sulfate has recently been described as a new marker for squamous cell differentiation in rabbit tracheal epithelial cells. We now report that normal human bronchial epithelial cells in cultu...

journal_title：Journal of cellular physiology

authors： Rearick JI,Hesterberg TW,Jetten AM

更新日期：1987-12-01 00:00:00

abstract：:These are the reflections of a retired physician who was introduced to cellular physiology in 1947 at the University of Pennsylvania. I majored in Zoology. I took the required major courses, which were interesting but not exciting. I was a premedical student at the time. Fortunately I was introduced to cellular physio...

journal_title：Journal of cellular physiology

authors： Perelman A

更新日期：2015-11-01 00:00:00

abstract：:MUC4 is a heterodimeric membrane mucin, composed of a mucin subunit ASGP-1 (MUC4alpha) and a transmembrane subunit ASGP-2 (MUC4beta), which has been implicated in the protection of epithelial cell surfaces. Surprisingly, development and characterization of a new monoclonal antibody (mAb), called 1G8, against ASGP-2 de...

journal_title：Journal of cellular physiology

authors： Zhang J,Perez A,Yasin M,Soto P,Rong M,Theodoropoulos G,Carothers Carraway CA,Carraway KL

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy. METHODS:Bioinf...

journal_title：Journal of cellular physiology

authors： Tian X,Ji Y,Liang Y,Zhang J,Guan L,Wang C

更新日期：2019-08-01 00:00:00

abstract：:In this study, we examine whether an anti-inflammatory thiourea derivative, compound #326, actions on ion channels. The effects of compound #326 on Ca2+ -activated K+ channels were evaluated by patch-clamp recordings obtained in cell-attached, inside-out or whole-cell configuration. In pituitary GH3 cells, compound #3...

journal_title：Journal of cellular physiology

authors： Wu SN,Chern JH,Shen S,Chen HH,Hsu YT,Lee CC,Chan MH,Lai MC,Shie FS

更新日期：2017-12-01 00:00:00