MiR-199a-3p inhibition facilitates cardiomyocyte differentiation of embryonic stem cell through promotion of MEF2C.

abstract：:Confluent cultures of adult bovine aortic endothelial (ABAE), corneal endothelial (BCE), and fetal bovine heart endothelial (FBHE) cells form a monolayer of highly flattened, closely apposed, and nonoverlapping cells. In ABAE and BCE cultures, this is associated with a 50-fold decrease in the rate of DNA sythesis and ...

journal_title：Journal of cellular physiology

authors： Savion N,Vlodavsky I,Greenburg G,Gospodarowicz D

更新日期：1982-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal and disabling neurodegenerative disease characterized by upper and lower motor neurons depletion. In our previous work, comprehensive genomic profiling of 41 motor cortex samples enabled to discriminate controls from sporadic ALS patients, and segregated these latter into...

journal_title：Journal of cellular physiology

authors： Bonaventura G,Iemmolo R,D'Amico AG,La Cognata V,Costanzo E,Zappia M,D'Agata V,Conforti FL,Aronica E,Cavallaro S

更新日期：2018-04-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a mortal cancer with gradually increasing incidences all over the world, whereas effective diagnosis and treatment for this disease are still lacking. As a classical long noncoding RNA (lncRNA), maternally expressed gene 3 (MEG3) has been reported to exhibit pivotal regulatory roles in the ...

journal_title：Journal of cellular physiology

authors： Li J,Jiang X,Li C,Liu Y,Kang P,Zhong X,Cui Y

更新日期：2019-12-01 00:00:00

abstract：:We analyzed the effect of exposure to hypoxic/hypercapnic (HH) gas mixture (5% O2 /9% CO2 ) on the maintenance of functional cord blood CD34(+) hematopoietic stem and progenitor cells in severe hypothermia (4°C) employing the physiological and proteomic approaches. Ten-day exposure to HH maintained the Day 0 (D-0) lev...

journal_title：Journal of cellular physiology

authors： Vlaski M,Negroni L,Kovacevic-Filipovic M,Guibert C,Brunet de la Grange P,Rossignol R,Chevaleyre J,Duchez P,Lafarge X,Praloran V,Schmitter JM,Ivanovic Z

更新日期：2014-12-01 00:00:00

abstract：:Wound healing is critically affected by age, ischemia, and growth factors such as TGFbeta1. The combined effect of these factors on fibroblast migration, an essential component of wound healing, is poorly understood. To address this deficiency, we examined expression of TGFbeta receptor type I and II (TGFbetaRI and RI...

journal_title：Journal of cellular physiology

authors： Mogford JE,Tawil N,Chen A,Gies D,Xia Y,Mustoe TA

更新日期：2002-02-01 00:00:00

abstract：:Rho is known as an important regulator of actin microfilament formation. We were led to study it because a dynamic rearrangement of actin filaments occurs during activation of gastric acid secretion. In order to use specific probes, the rabbit gastric gland culture system was employed and the various genes were expres...

journal_title：Journal of cellular physiology

authors： Tashiro K,Nagao T,Kurose H,Ichijo H,Urushidani T

更新日期：2003-12-01 00:00:00

abstract：:The prevalence of chronic hyperglycemia and its complications, imposing a critical burden on the worldwide economy and the global healthcare system, is a pressing issue. Mounting evidence indicates that oxidative stress and hypoxia, two noticeable features of hyperglycemia, play a joint crucial role in mediating cellu...

journal_title：Journal of cellular physiology

authors： Huang YT,Liu CH,Yang YC,Aneja R,Wen SY,Huang CY,Kuo WW

更新日期：2019-08-01 00:00:00

abstract：:In spite of the apparent depletion of mast cells in tissues of mutant mice of W/Wv genotype, cells with many features of mast cells do develop when bone marrow cells of W/Wv mice are cultured in the presence of pokeweed mitogen-stimulated spleen cell-conditioned medium (PWM-SCM). In order to resolve this discrepancy a...

journal_title：Journal of cellular physiology

authors： Fujita J,Nakayama H,Onoue H,Kanakura Y,Nakano T,Asai H,Takeda S,Honjo T,Kitamura Y

更新日期：1988-01-01 00:00:00

abstract：:P-glycoproteins (Pgp) are comprised of a small family of plasma membrane proteins whose abundance in cultured cells is often associated with the multidrug resistance phenotype. Overexpression of Pgp has been observed in many types of human cancers, but the molecular basis for this overexpression has not been establish...

journal_title：Journal of cellular physiology

authors： Lee CH,Bradley G,Ling V

更新日期：1998-10-01 00:00:00

abstract：:Leukotriene C4 is an arachidonic acid metabolite and an important mediator of inflammation and anaphylaxis that is known to induce production of prostacyclin in endothelial cells. The goal of this study was to examine the signal transduction mechanisms activated by leukotriene C4 stimulation. Formation of inositol pho...

journal_title：Journal of cellular physiology

authors： Geirsson A,Halldórsson H,Magnúsdóttir K,Kjeld M,Thorgeirsson G

更新日期：1998-10-01 00:00:00

abstract：:Hyaluronan (HA) accumulates in vascular disease but its functional role is not fully understood. To investigate the impact of HA enriched extracellular matrices (ECM) on cell phenotype, arterial smooth muscle cells (ASMCs) were transduced with retroviral constructs (LXSN) encoding murine has-1, has-2, and has-3. HA sy...

journal_title：Journal of cellular physiology

authors： Wilkinson TS,Bressler SL,Evanko SP,Braun KR,Wight TN

更新日期：2006-02-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) promotes bone formation by stimulating proliferation and differentiation of osteoblasts. Bone sialoprotein (BSP), is thought to function in the initial mineralization of bone, is selectively expressed by differentiated osteoblast. To determine the molecular mechanism of IGF-I regul...

journal_title：Journal of cellular physiology

authors： Nakayama Y,Nakajima Y,Kato N,Takai H,Kim DS,Arai M,Mezawa M,Araki S,Sodek J,Ogata Y

更新日期：2006-08-01 00:00:00

abstract：:Previous study suggested that the receptor component protein (RCP), one of the components of calcitonin gene-related peptide (CGRP) receptor, plays a multiple role in the cellular signal transduction. The study was designed to investigate whether or not the RCP involved in the regulation of caveolin-1/extracellular si...

journal_title：Journal of cellular physiology

authors： Guo F,Yang L,Luo J,Quan H,Wang Z,Peng H,Hong C,Li J,Jiang Z,Zhang L,Qin X

更新日期：2018-10-01 00:00:00

abstract：:Regulation of lipid synthesis from acetate in human diploid fibroblast cultures has been studied at various passage levels and at different stages of cell growth. When cultures were transferred to lipid free medium, a stimulation of [14C]acetate incorporation into lipid occurred within three to six hours after removal...

journal_title：Journal of cellular physiology

authors： Howard BV,Howard WJ,Kefalides NA

更新日期：1976-10-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in head and neck cancer and a global cause of cancer-related death. Due to the poor survival rates associated with OSCC, there is a growing need to develop novel technologies and predictive biomarkers to improve disease diagnosis. The identification of ...

journal_title：Journal of cellular physiology

authors： Wang Q,Zhi Y,Ren W,Li S,Dou Z,Xing X,Quan X,Wang Y,Jiang C,Liang X,Gao L,Zhi K

更新日期：2019-01-28 00:00:00

abstract：:Several agents that act through G-protein-coupled receptors and also stimulate phosphoinositide-specific phospholipase C (PI-PLC), including angiotensin II, vasopressin, norepinephrine, and prostaglandin (PG) F2alpha, activated the ERK1 (p44mapk) and ERK2 (p42mapk) members of the mitogen-activated protein (MAP) kinase...

journal_title：Journal of cellular physiology

authors： Melien O,Thoresen GH,Sandnes D,Ostby E,Christoffersen T

更新日期：1998-06-01 00:00:00

abstract：:Cucurbitacin B (CuB) is a natural tetracyclic triterpene product that displays antitumor activity against a wide variety of cancers. In this study, we explored the antipancreatic cancer activity of CuB via the inhibition of expression of the cancer-related long noncoding RNA, actin filament-associated protein 1-antise...

journal_title：Journal of cellular physiology

authors： Zhou J,Liu M,Chen Y,Xu S,Guo Y,Zhao L

更新日期：2019-04-01 00:00:00

abstract：:With the long-range goals of elucidating the biochemical genetics and the phenotypic expression, both in vitro and in vivo, of mutator strains of mammalian cells, we have isolated and partially characterized a series of drug-resistant mutants from a subline a feeder-dependent parental mouse teratocarcinoma line (PSA-1...

journal_title：Journal of cellular physiology

authors： Aizawa S,Loeb LA,Martin GM

更新日期：1983-04-01 00:00:00

abstract：:It is presently unclear what role elevations in intracellular calcium concentration ([Ca2+]i) play in the control of monokine secretion, or whether such alterations underlie the ability of physiologic stimuli to induce production of these important signalling molecules. To address these issues, we have performed exper...

journal_title：Journal of cellular physiology

authors： Marriott I,Bost KL,Mason MJ

更新日期：1998-11-01 00:00:00

abstract：:Leukemic cells in the myeloblastic stage from a murine myeloid leukemia cell line (M1) were induced to differentiate to macrophages by lipopolysaccharide (LPS) from Gram-negative bacteria. A granulocyte-macrophage colony-stimulating factor (CSF) was produced only during differentiation. After induction of differentiat...

journal_title：Journal of cellular physiology

authors： Maeda M,Ichikawa Y

更新日期：1980-03-01 00:00:00

abstract：:Extracellular high K(+) (75 mM) increased intracellular Ca(2+) concentrations in cultured rat hippocampal astrocytes, and the Ca(2+) rise was abolished by deleting extracellular Ca(2+) or cadmium, a non-selective inhibitor of voltage-dependent calcium channels (VDCCs). In the reverse transcription-polymerase chain rea...

journal_title：Journal of cellular physiology

authors： Yaguchi T,Nishizaki T

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is characterized by the apoptosis resistance and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Its pathogenesis has not been revealed. Here, we carried out experiments to investigate the functions of miR-140-5p and tumor necrosis factor-α (TNF-α). ...

journal_title：Journal of cellular physiology

authors： Zhu TT,Zhang WF,Yin YL,Liu YH,Song P,Xu J,Zhang MX,Li P

更新日期：2019-06-01 00:00:00

abstract：:We have previously shown that mitochondrial activity is an important regulator of myoblast differentiation, partly through processes targeting myogenin expression. Here, we investigated the possible involvement of c-myc in these processes. Inhibition of mitochondrial activity by chloramphenicol abrogated the decrease ...

journal_title：Journal of cellular physiology

authors： Seyer P,Grandemange S,Busson M,Carazo A,Gamaléri F,Pessemesse L,Casas F,Cabello G,Wrutniak-Cabello C

更新日期：2006-04-01 00:00:00

abstract：:We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1-nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1...

journal_title：Journal of cellular physiology

authors： Troutt AB,Lee F

更新日期：1989-01-01 00:00:00

abstract：:Restitution is a crucial event during the healing of superficial injury of the gastric mucosa involving epithelial cell sheet movement into the damaged area. We demonstrated that growth factors promote the restitution of human gastric epithelial cells. However, the intracellular signaling pathways that transmit extrac...

journal_title：Journal of cellular physiology

authors： Tétreault MP,Chailler P,Beaulieu JF,Rivard N,Ménard D

更新日期：2008-02-01 00:00:00

abstract：:The 94-kDa glucose-regulated protein (GRP94) is a glycoprotein in the endoplasmic reticulum (ER). It has been characterized as a Ca2+-binding protein and a molecular chaperone. In this report we show that highly purified GRP94 exhibits an active Mg2+-dependent serine kinase activity (termed 94-kinase). The 94-kinase c...

journal_title：Journal of cellular physiology

authors： Ramakrishnan M,Schönthal AH,Lee AS

更新日期：1997-02-01 00:00:00

abstract：:Liver fibrosis (LF) is the result of a vicious cycle between inflammation-induced chronic hepatocyte injury and persistent activation of hepatic stellate cells (HSCs). Mesenchymal stem cell (MSC)-based therapy may represent a potential remedy for treatment of LF. However, the fate of transplanted MSCs in LF remains la...

journal_title：Journal of cellular physiology

authors： Wang HY,Li C,Liu WH,Deng FM,Ma Y,Guo LN,Kong H,Hu KA,Liu Q,Wu J,Sun J,Liu YL

更新日期：2020-03-01 00:00:00

abstract：:Topical intranasal application of the antifungal Amphotericin B (AmphoB) has been shown as an effective medical treatment of chronic rhinosinusitis. Because this antibiotic forms channels in lipid membranes, we considered the possibility that it affects the properties and/or cell surface expression of ion channels/pum...

journal_title：Journal of cellular physiology

authors： Jornot L,Rochat T,Caruso A,Lacroix JS

更新日期：2005-09-01 00:00:00

abstract：:Adsorption of Sendai virus at high multiplicity (500-1,000 HAU/10(6) cells) to HeLa cells grown in monolayers causes immediate changes in the ion barrier of the cell membrane, as well as changes in the morphology of the virus-treated cells. Within minutes of adsorption the cells begin to lose potassium and an extensiv...

journal_title：Journal of cellular physiology

authors： Spiegelstein PF,Haimsohn M,Gitelman J,Kohn A

更新日期：1978-05-01 00:00:00

abstract：:Asthma is the most common respiratory disease accompanied by lung inflammatory disorders. The main symptoms are airway obstruction, chronic inflammation due to mast cell and eosinophil activity, and the disturbance of immune responses mostly mediated by the Th2 response. Genetic background and environmental factors al...

journal_title：Journal of cellular physiology

authors： Mousavi SR,Ahmadi A,Jamalkandi SA,Salimian J

更新日期：2019-12-01 00:00:00