Presence of MUC4 in human milk and at the luminal surfaces of blood vessels.

abstract：:Runx2 and Runx3 are known to be expressed in the growth plate during endochondral bone formation. Here we addressed the functional role of Runx3 as distinct from Runx2 by using two models of postnatal bone repair: fracture healing that proceeds by an endochondral process and marrow ablation that proceeds by only an in...

journal_title：Journal of cellular physiology

authors： Wigner NA,Soung do Y,Einhorn TA,Drissi H,Gerstenfeld LC

更新日期：2013-11-01 00:00:00

abstract：:Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

journal_title：Journal of cellular physiology

authors： Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:MiR-152 has been reported as a tumor suppressor microRNA that is downregulated in a number of cancers, including colorectal cancer (CRC). A recent study suggested that miR-152 could be one of the key regulators of CRC. The aim of this study is to investigate the role of miR-152 in CRC and its mechanisms. ME...

journal_title：Journal of cellular physiology

authors： Ghazanchaei A,Mansoori B,Mohammadi A,Biglari A,Baradaran B

更新日期：2018-01-01 00:00:00

abstract：:Low-power laser irradiation (LPLI) has been shown to exert promotive effects on cell survival and proliferation through activation of various signaling pathways. Estrogen receptors (ERs, ERα, and ERβ) are ligand-activated transcription factors, which regulate target gene expression, promote cell proliferation, and res...

journal_title：Journal of cellular physiology

authors： Huang L,Tang Y,Xing D

更新日期：2013-05-01 00:00:00

abstract：:Protein sorting through vesicular compartments is highly regulated to maintain the integrity and signaling of intracellular organelles in eukaryotic cells. Sorting Nexin-2 (SNX2) is involved in protein sorting in the trans-Golgi network, endosome, and/or lysosome compartments, with loss of function leading to defect i...

journal_title：Journal of cellular physiology

authors： Abdul-Ghani M,Hartman KL,Ngsee JK

更新日期：2005-07-01 00:00:00

abstract：:Three-dimensional (3D) culture platforms have been explored to establish physiologically relevant cell culture environment and permit expansion scalability; however, little is known about the mechanisms underlying the regulation of pluripotency of human induced pluripotent stem cells (hiPSCs). This study elucidated ep...

journal_title：Journal of cellular physiology

authors： Thanuthanakhun N,Kino-Oka M,Borwornpinyo S,Ito Y,Kim MH

更新日期：2020-12-10 00:00:00

abstract：:Several papers report a hypoxia-induced upregulation of the endothelial nitric oxide synthase (eNOS) mRNA expression. Since there is no known hypoxia-sensitive element binding site in the eNOS promoter, we reasoned that the effect of hypoxia could be simulated by a metabolically elicited alteration of the redox state....

journal_title：Journal of cellular physiology

authors： Hoffmann A,Gloe T,Pohl U

更新日期：2001-07-01 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) contributes to the pathogenesis of non-small-cell lung carcinomas (NSCLC) and gefitinib, a selective reversible EGFR inhibitor, is effective in treating patients with NSCLC. However, clinical resistance to gefitinib is a frequent occurrence highlighting the nee...

journal_title：Journal of cellular physiology

authors： Emdad L,Lebedeva IV,Su ZZ,Gupta P,Sarkar D,Settleman J,Fisher PB

更新日期：2007-02-01 00:00:00

abstract：:Lactoferrin, a single chain cationic glycoprotein, present in the secondary granules of neutrophils, acts as a negative feedback regulator of myelopoiesis. Specific receptors for lactoferrin were detected on the surface of different hematopoietic cell types. The influence of lactoferrin on cell growth in culture has b...

journal_title：Journal of cellular physiology

authors： Garré C,Bianchi-Scarrá G,Sirito M,Musso M,Ravazzolo R

更新日期：1992-12-01 00:00:00

abstract：:Human cell lines derived from a melanoma and a colon carcinoma, and cultures of human melanocytes and intestinal epithelial cells, as well as a mouse mesenchymal non-neoplastic cell line and a malignant subline of the same have been quantitatively studied in tissue culture for their sensitivity to thymidine. All three...

journal_title：Journal of cellular physiology

authors： Lee SS,Giovanella BC,Stehlin JS Jr

更新日期：1977-09-01 00:00:00

abstract：:The extent to which autolytic microbial enzymes are involved in the fate of microorganisms ingested by phagocytes has not been determined. It is known, however, that activation of degradative enzymes occurs during certain microbicidal events. We examined the possible role of the pneumococcal autolytic enzyme (an N-ace...

journal_title：Journal of cellular physiology

authors： Tomasz A,Beckerdite S,McDonnell M,Elsbach P

更新日期：1977-08-01 00:00:00

abstract：:Data on the biological effects of some overexpressed oncogenes and their cooperation with cellular factors are, at least partially, contradictory. There are reports on the strong pro-apoptotic action of temperature-sensitive (ts) p53(135val) in transformed cells at permissive temperature. However, in our experience ve...

journal_title：Journal of cellular physiology

authors： Schmid G,Kramer MP,Wesierska-Gadek J

更新日期：2009-05-01 00:00:00

abstract：:Brain ischemia is associated with an acute release of pro-inflammatory cytokines, notably TNF-alpha and IL-6 and failure of the blood-brain barrier. Shear stress, hypoxia-hypoglycemia, and blood leukocytes play a significant role in blood-brain barrier failure during transient or permanent ischemia. However, these mec...

journal_title：Journal of cellular physiology

authors： Krizanac-Bengez L,Mayberg MR,Cunningham E,Hossain M,Ponnampalam S,Parkinson FE,Janigro D

更新日期：2006-01-01 00:00:00

abstract：:Colon cancer remains one of the lethal malignancies in the world. Aberrant activation of canonical Wnt/β-catenin signaling pathway has been observed in colon cancer. In contrast, the non-canonical Wnt signaling functions remain obscure. Wnt5a is a representative non-canonical Wnt ligand which has gained extensive atte...

journal_title：Journal of cellular physiology

authors： Cheng R,Sun B,Liu Z,Zhao X,Qi L,Li Y,Gu Q

更新日期：2014-12-01 00:00:00

abstract：:Stimulation of postconfluent Swiss 3T3 cells in serum-free medium with 4.3 mM Ca2+ results in marked increases in both released and cell-associated plasminogen activator (PA). Increased release of PA commenced approximately 10 to 12 hours post-stimulation and continued to increase steadily until 48 hours at which time...

journal_title：Journal of cellular physiology

authors： Chou IN,Cox R,Black PH

更新日期：1979-09-01 00:00:00

abstract：:We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1-nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1...

journal_title：Journal of cellular physiology

authors： Troutt AB,Lee F

更新日期：1989-01-01 00:00:00

abstract：:A basic understanding of the recruitment of quiescent tumor cells into the cell cycle would be an important contribution to tumor biology and therapy. As a first step in pursuing this goal, we have investigated the regrowth kinetics of cells from different regions in multicellular spheroids of rodent and human origin....

journal_title：Journal of cellular physiology

authors： Freyer JP,Schor PL

更新日期：1989-02-01 00:00:00

abstract：:Oral administration of ajulemic acid (AjA), a cannabinoid acid devoid of psychoactivity, prevents joint tissue injury in rats with adjuvant induced arthritis. Because activation of osteoclasts is central to the pathogenesis of bone erosion in patients with rheumatoid arthritis (RA), we investigated the influence of Aj...

journal_title：Journal of cellular physiology

authors： George KL,Saltman LH,Stein GS,Lian JB,Zurier RB

更新日期：2008-03-01 00:00:00

abstract：:Alpha-2-glycoprotein 1, zinc-binding (AZGP1), known as zinc-alpha-2-glycoprotein (ZAG), is a multifunctional secretory glycoprotein and relevant to cancer metastasis. Little is known regarding the underlying mechanisms of AZGP1 in prostate cancer (PCa). In the present study, we report that AZGP1 is an androgen-respons...

journal_title：Journal of cellular physiology

authors： Cao R,Ke M,Wu Q,Tian Q,Liu L,Dai Z,Lu S,Liu P

更新日期：2019-08-01 00:00:00

abstract：:We have previously reported that the proliferation of cloned MCF-7 and T47D human mammary tumor cells can be inhibited by increasing concentrations of charcoal-dextran stripped female human serum (CDFHS). The maximal proliferation rate was restored by the addition of 3 X 10(-11) M estradiol-17 beta to the culture medi...

journal_title：Journal of cellular physiology

authors： Schatz RW,Soto AM,Sonnenschein C

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia. METHODS:A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and t...

journal_title：Journal of cellular physiology

authors： He H,Hu P,Tang Y,Xu X

更新日期：2019-07-01 00:00:00

abstract：:Nucleotide receptors signaling affects cell proliferation, with possible implications on tumorigenic processes. However, molecular targets and action mechanisms of the extracellular nucleotides are still poorly elucidated. We have previously shown in ARO cells that APE1/Ref-1, a transcriptional coactivator responsible...

journal_title：Journal of cellular physiology

authors： Pines A,Bivi N,Vascotto C,Romanello M,D'Ambrosio C,Scaloni A,Damante G,Morisi R,Filetti S,Ferretti E,Quadrifoglio F,Tell G

更新日期：2006-10-01 00:00:00

abstract：:Butyrate and acetate are bacterial metabolites present in the large intestine lumen. Although butyrate is well known to inhibit the in vitro proliferation of human colon carcinoma cells in a process involving the hyperacetylation of specific nuclear histones, little is known about the possible link between butyrate me...

journal_title：Journal of cellular physiology

authors： Andriamihaja M,Chaumontet C,Tome D,Blachier F

更新日期：2009-01-01 00:00:00

abstract：:Fibrosis is a common pathological condition associated with abnormal repair after tissue injury. However, the etiology and molecular mechanisms of fibrosis are still not well-understood. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) belongs to the TNF superfamily and acts by binding to its recepto...

journal_title：Journal of cellular physiology

authors： Zhang Y,Zeng W,Xia Y

更新日期：2020-09-30 00:00:00

abstract：:Signal transduction of fibroblast growth factor (FGF) receptors is known to involve tyrosine phosphorylation of several substrates, including Grb2, phospholipase C-gamma, and phosphatidylinositol 3-kinase, whereas the role of G-proteins in FGF receptor signaling is controversial. In the present study we investigated t...

journal_title：Journal of cellular physiology

authors： Piiper A,Stryjek-Kaminska D,Gebhardt R,Zeuzem S

更新日期：1996-04-01 00:00:00

abstract：:Polycystin-1 regulates a number of cellular processes through the formation of complexes with the polycystin-2 ion channel or with other signal transduction proteins. Polycystin-1 is expressed in many tissues but other members of this gene family are distributed in a more restricted fashion. PKDREJ expression has been...

journal_title：Journal of cellular physiology

authors： Sutton KA,Jungnickel MK,Ward CJ,Harris PC,Florman HM

更新日期：2006-11-01 00:00:00

abstract：:A key attribute of the stringent response of bacteria is the rapid inhibition of ribosomal RNA synthesis mediated by unusual nucleotides in respnse to uncharged tRNA. The question as to whether mammalian cells show a stringent response analogous to that of bacteria was critically tested by the effective rapid amino ac...

journal_title：Journal of cellular physiology

authors： Pollard JW,Lam T,Stanners CP

更新日期：1980-11-01 00:00:00

abstract：:Human embryonic neutrophils (N) in the liver (from 8.5 mm crown-rump length) are alkaline phosphatase (AP) negative during the first trimester of pregnancy. Early bone marrow granulocytes (from eleventh to sixteenth weeks of gestation) behave similarly. Only a small percentage of slightly AP positive cells could be fo...

journal_title：Journal of cellular physiology

authors： Kelemen E,Gulya E,Vass K

更新日期：1978-06-01 00:00:00

abstract：:Reduced sperm motility (asthenospermia) and resulting infertility arise from deletion of the Plasma Membrane Ca2+ -ATPase 4 (Pmca4) gene which encodes the highly conserved Ca2+ efflux pump, PMCA4. This is the major Ca2+ clearance protein in murine sperm. Since the mechanism underlying asthenospermia in PMCA4's absence...

journal_title：Journal of cellular physiology

authors： Olli KE,Li K,Galileo DS,Martin-DeLeon PA

更新日期：2018-01-01 00:00:00

abstract：:At the initial stage of cell-cell contact of epithelial cells, primordial spot-like junctions are formed at the tips of thin cellular protrusions radiating from adjacent cells, where E-cadherin and ZO-1 are precisely coconcentrated (Yonemura et al., 1995, J. Cell Sci. 108:127-142). In fully polarized epithelial cells,...

journal_title：Journal of cellular physiology

authors： Ando-Akatsuka Y,Yonemura S,Itoh M,Furuse M,Tsukita S

更新日期：1999-05-01 00:00:00