Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.

abstract：:Cultured bovine aortic endothelial cells were fixed and stained with NBD-phallicidin and quantitated with a digital image analyzer for changes in actin cables and surface area. Serotonin (5-HT), norepinephrine (NE), dopamine and histamine (all at 10(-4)M concentrations) were tested for their ability to induce cytoskel...

journal_title：Journal of cellular physiology

authors： Welles SL,Shepro D,Hechtman HB

更新日期：1985-06-01 00:00:00

abstract：:Retinopathy has become one of the major factors that lead to blindness worldwide. Although many clinical therapies are concerned about such disease, most of them focus on symptoms alleviation. In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells trans...

journal_title：Journal of cellular physiology

authors： Ma QQ,Liu FY,Shi M,Sun CH,Tan Z,Chang XD,Li QP,Feng ZC

更新日期：2019-11-01 00:00:00

abstract：:Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and immune cells in tumor microenvironment to suppress anti-tumor responses. Two cell surface expressed ...

journal_title：Journal of cellular physiology

authors： Kazemi MH,Raoofi Mohseni S,Hojjat-Farsangi M,Anvari E,Ghalamfarsa G,Mohammadi H,Jadidi-Niaragh F

更新日期：2018-03-01 00:00:00

abstract：:We have examined nucleoside transport (NT) in a cell line derived from primary day 7 murine bone marrow macrophages (S1 macrophages) in response to the macrophage growth factor, colony-stimulating factor 1 (CSF-1). Adenosine and uridine transport in quiescent S1 macrophages occurred primarily by two facilitated diffus...

journal_title：Journal of cellular physiology

authors： Meckling-Gill KA,Guilbert L,Cass CE

更新日期：1993-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the most common malignancy in head and neck cancer and a global cause of cancer-related death. Due to the poor survival rates associated with OSCC, there is a growing need to develop novel technologies and predictive biomarkers to improve disease diagnosis. The identification of ...

journal_title：Journal of cellular physiology

authors： Wang Q,Zhi Y,Ren W,Li S,Dou Z,Xing X,Quan X,Wang Y,Jiang C,Liang X,Gao L,Zhi K

更新日期：2019-01-28 00:00:00

abstract：:The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial cells (HAECs) and smooth muscle cells (HASMCs) were treated with ...

journal_title：Journal of cellular physiology

authors： Millar SA,Anderson SI,O'sullivan SE

更新日期：2019-11-01 00:00:00

abstract：:Type 1 diabetes is inhibited in diabetes-prone BioBreeding (BBdp) rats fed a low-antigen hydrolyzed casein (HC) diet. In cereal-fed BBdp rats, islet expansion is defective accompanied by a futile upregulation of islet neogenesis without increased islet mass, due to a subtle blockage in islet cell cycle. We hypothesize...

journal_title：Journal of cellular physiology

authors： Wang GS,Kauri LM,Patrick C,Bareggi M,Rosenberg L,Scott FW

更新日期：2010-08-01 00:00:00

abstract：:3-Hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR) is the key and rate-limiting enzyme of cholesterol biosynthetic pathway. Although HMG-CoAR activity has already been related to the differentiation of some cellular lines there are no studies that analyze the role of HMG-CoAR, and the pathway it is involved wi...

journal_title：Journal of cellular physiology

authors： Martini C,Trapani L,Narciso L,Marino M,Trentalance A,Pallottini V

更新日期：2009-08-01 00:00:00

abstract：:Chick embryo fibroblasts were maintained at confluency for up to 35 days in medium containing 0.5% or 0.75% fetal bovine serum or 2.5% or 5.0% horse serum. At weekly intervals cells were subcultured and serially propagated in medium containing 10% FBS until their replicative lifespans were completed. The results showe...

journal_title：Journal of cellular physiology

authors： Nielsen PJ,Ryan JM

更新日期：1981-06-01 00:00:00

abstract：:The biological effects of the Corticotropin-releasing factor (CRF) family of neuropeptides are mediated by mobilization of [Ca(2+)]. Aim of the current work was to examine if the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the effect of CRF peptides in catecholamine synthesi...

journal_title：Journal of cellular physiology

authors： Dermitzaki E,Tsatsanis C,Gravanis A,Margioris AN

更新日期：2012-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) is a small molecule (19-25 nucleotide) noncoding RNA that inhibits the expression of target messenger RNA (mRNA) at the posttranscriptional level as an endogenous regulator. There is an increasing evidence that miR-199a-3p has a significant effect on the development of multiple tumors. However, the ...

journal_title：Journal of cellular physiology

authors： Chen HP,Wen J,Tan SR,Kang LM,Zhu GC

更新日期：2019-12-01 00:00:00

abstract：:Nemo-like kinase (Nlk) is related to the mitogen-activated protein (MAP) kinases and known to regulate signaling pathways involved in osteoblastogenesis. In vitro Nlk suppresses osteoblastogenesis, but the consequences of the Nlk inactivation in the skeleton in vivo are unknown. To study the function of Nlk, Nlk(loxP/...

journal_title：Journal of cellular physiology

authors： Canalis E,Kranz L,Zanotti S

更新日期：2014-11-01 00:00:00

abstract：:A temperature-sensitive mutant with a defect in glycoprotein synthesis and a cell cycle (G1)-specific arrest at the nonpermissive temperature (Tenner et al., J. Cell. Physiol., 90:145-160, 1977; Tenner and Scheffler, J. Cell. Physiol., 98:251-266, 1979) was investigated further after a human epidermal growth factor (E...

journal_title：Journal of cellular physiology

authors： Feige JJ,Scheffler IE

更新日期：1987-12-01 00:00:00

abstract：:When 3T6 cells undergo a serum-induced transition from resting to growing state, the number of ribosomes and the amounts of mRNA increase as the cells prepare for DNA synthesis. We have examined the effect of preventing ribosome synthesis during this transition. When resting cells are stimulated to grow in the presenc...

journal_title：Journal of cellular physiology

authors： Johnson LF,Penman S,Green H

更新日期：1975-12-01 00:00:00

abstract：:Transforming growth factor beta type 1 (TGF-beta 1) was reacted with NHS-biotin to yield a derivative of TGF-beta 1 which was biotinylated on lysine residues. The biotinylated form of TGF-beta 1 was separated from the unreacted material by reverse phase chromatography. In three separate bioassays, the derivatized pept...

journal_title：Journal of cellular physiology

authors： Newman W,Beall LD,Bertolini DR,Cone JL

更新日期：1989-10-01 00:00:00

abstract：:The role of hsp27 as an inhibitor of actin polymerization was considered in the context of the actin cytoskeleton and its relationship with focal adhesion formation. The aim of this study was to evaluate the potential effects of hsp27 on focal adhesion formation as a relevant biological consequence of actin stress fib...

journal_title：Journal of cellular physiology

authors： Schneider GB,Hamano H,Cooper LF

更新日期：1998-12-01 00:00:00

abstract：:Mouse heptoma cells that secrete large amounts of alpha-fetoprotein (AFP) and albumin have been crossed with rat hepatoma cells that secret only albumin, and in relatively small amounts, to investigate the influence of each parental genome upon the expression of serum proteins. All of the ten independent hybrid clones...

journal_title：Journal of cellular physiology

authors： Cassio D,Hassoux R,Dupiers M,Uriel J,Weiss MC

更新日期：1980-09-01 00:00:00

abstract：:Parkinsonism is one of the most common aging neurodegenerative disorders. This study aims to compare the therapeutic effect of stem cell versus its conditioned medium in the Parkinsonism model. Parkinsonism was induced by daily subcutaneous injection of 0.5 mg/kg of rotenone dissolved in dimethyl sulfoxide for 28 days...

journal_title：Journal of cellular physiology

authors： Abdelwahab S,Elsebay SAG,Fouli Gaber M,Abdel-Hafez SMN

更新日期：2021-01-01 00:00:00

abstract：:There is evidence that cadmium can initiate carcinogenesis. However, the underlying mechanisms remain unknown. There is also evidence that moderate centrosome amplification can initiate tumorigenesis. The present study investigated whether cadmium could trigger cell centrosome amplification, and examined the underlyin...

journal_title：Journal of cellular physiology

authors： Zhang RK,Wang P,Lu YC,Lang L,Wang L,Lee SC

更新日期：2019-08-01 00:00:00

abstract：:Wnt1-inducible signaling pathway protein-1 (WISP1) is a Cyr61/CTGF/NOV (CCN) family matricellular protein involved in adipogenesis and low-grade inflammation in obesity. However, the roles of WISP1 in hepatic steatosis and insulin resistance in skeletal muscle remain elusive. Mouse primary hepatocytes and differentiat...

journal_title：Journal of cellular physiology

authors： Jung TW,Kang C,Goh J,Chae SI,Kim HC,Lee TJ,Abd El-Aty AM,Jeong JH

更新日期：2018-08-01 00:00:00

abstract：:The antibody-secreting murine hybridoma, CC9C10, was grown in batch culture in a medium containing 20 mM glucose and 2 mM glutamine. After 2 days of exponential growth, the glutamine content of the medium was completely depleted, whereas the glucose content was reduced to 60% of the original concentration. The glucose...

journal_title：Journal of cellular physiology

authors： Petch D,Butler M

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of polo-like kinase 1 (PLK1) inhibition on cisplatin (DDP)-resistant gastric cancer (GC) cells. METHODS:The transcriptional level of PLK1 was measured by quantitative reverse-transcription polymerase chain reaction. Expressions of PLK1 and its downstream mediators as...

journal_title：Journal of cellular physiology

authors： Chen Z,Chai Y,Zhao T,Li P,Zhao L,He F,Lang Y,Qin J,Ju H

更新日期：2019-05-01 00:00:00

abstract：:Hemodynamic forces influence many endothelial cell functions. The coupling between hemodynamic forces and cell function could be mediated by mechano-sensitive ion channels present in the plasma membrane of endothelial cells. Because one of these channels is permeable to Ca2+, we tested whether hemodynamic forces influ...

journal_title：Journal of cellular physiology

authors： Oliver JA,Chase HS Jr

更新日期：1992-04-01 00:00:00

abstract：:Rat pheochromocytoma PC12 cells respond to the binding of nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) by extending neurites in a manner resembling sympathetic neurons. This response requires cell attachment to an appropriate substratum (Fujii et al., J. Neurosci., 2:1157, 1982); attachment fact...

journal_title：Journal of cellular physiology

authors： Schwarz MA,Brown PJ,Eveleth DD,Bradshaw RA

更新日期：1989-01-01 00:00:00

abstract：:The development and progression of hepatocellular carcinoma (HCC) have been associated with abnormal cellular metabolism. Gene Expression Profiling Interactive Analysis RNA sequencing data revealed caveolin-1 (CAV-1) and hexokinase 2 (HK2) messenger RNA (mRNA) were significantly upregulated in human HCC compared with ...

journal_title：Journal of cellular physiology

authors： Chai F,Li Y,Liu K,Li Q,Sun H

更新日期：2019-02-01 00:00:00

abstract：:Impaired cardiac control of intracellular diastolic Ca(2+) gives rise to arrhythmias. Whereas exercise training corrects abnormal cyclic Ca(2+) handling in heart failure, the effect on diastolic Ca(2+) remains unstudied. Here, we studied the effect of exercise training on the generation and propagation of spontaneous ...

journal_title：Journal of cellular physiology

authors： Kemi OJ,MacQuaide N,Hoydal MA,Ellingsen O,Smith GL,Wisloff U

更新日期：2012-01-01 00:00:00

abstract：:Terminal deoxynucleotidyl transferase (TdT) is a template-independent DNA polymerase that is transiently expressed during the normal development of T and B lymphocytes. Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines. We ...

journal_title：Journal of cellular physiology

authors： Beland JL,Yuille MA,Hugunin M,Zhang XM,Silverstone AE

更新日期：1990-03-01 00:00:00

abstract：:Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation. It is well established that HCO3- is essential for capacitation because it activates the atypical soluble adenylate cyclase ADCY10 leading to cAMP production, an...

journal_title：Journal of cellular physiology

authors： Puga Molina LC,Pinto NA,Torres Rodríguez P,Romarowski A,Vicens Sanchez A,Visconti PE,Darszon A,Treviño CL,Buffone MG

更新日期：2017-06-01 00:00:00

abstract：:Osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease. Probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease. Here, we ...

journal_title：Journal of cellular physiology

authors： McCabe LR,Irwin R,Schaefer L,Britton RA

更新日期：2013-08-01 00:00:00

abstract：:Versican is a large chondroitin sulfate proteoglycan and belongs to the family of lecticans. Versican possesses two globular domains, G1 and G3 domain, separated by a CS-attachment region. The CS-attachment region present in the middle region is divided into two spliced domains named CSalpha and beta. Alternative spli...

journal_title：Journal of cellular physiology

authors： Sheng W,Dong H,Lee DY,Lu WY,Yang BB

更新日期：2007-04-01 00:00:00