Nemo-like kinase regulates postnatal skeletal homeostasis.

abstract：:gamma-Glutamyl transpeptidase has multi-catalytic activities. It degrades glutathione and can produce ammonia from glutamine. The present study was designed to examine whether the decreased cell proliferation, cellular glutathione content and concurrent increase in ammonia production in senescent cells in culture are ...

journal_title：Journal of cellular physiology

authors： Takahashi S,Nakagawa S,Zeydel M,Bhargava G

更新日期：1985-10-01 00:00:00

abstract：:The specific activity of a peroxisomal enzyme, lactate oxidase, and of pyruvate kinase and lactate dehydrogenase, which are not peroxisomal, increased rapidly when shaken cultures of Tetrahymena were transferred to conditions of oxygen restriction and supplemented with glucose. Two other peroxisomal enzymes, catalase ...

journal_title：Journal of cellular physiology

authors： Levy MR

更新日期：1975-02-01 00:00:00

abstract：:Matrix metalloproteinase-2 (MMP-2) is best understood for its biological actions outside the cell. However, MMP-2 also localizes to intracellular compartments and the cytosol where it has several substrates, including troponin I (TnI). Despite a growing list of cytosolic substrates, we currently do not know the mechan...

journal_title：Journal of cellular physiology

authors： Ali MA,Chow AK,Kandasamy AD,Fan X,West LJ,Crawford BD,Simmen T,Schulz R

更新日期：2012-10-01 00:00:00

abstract：:Although the type 1 insulin-like growth factor receptor (IGF-IR) is a potent inhibitor of apoptosis, its C-terminus sequence sends contradictory signals, including a clearly proapoptotic signal. We have synthesized a peptide, peptide 2, having the sequence of the IGF-IR from residue 1282 to residue 1298 (C-terminus of...

journal_title：Journal of cellular physiology

authors： Reiss K,Yumet G,Shan S,Huang Z,Alnemri E,Srinivasula SM,Wang JY,Morrione A,Baserga R

更新日期：1999-10-01 00:00:00

abstract：:Previous studies demonstrated that overexpression of the type-1 insulin-like growth factor (IGF) receptor (IGF-1R) in skeletal myogenic cell lines increased proliferation and differentiation responses to IGF. However, it was unclear if such manipulations in primary, untransformed skeletal myogenic cells would result i...

journal_title：Journal of cellular physiology

authors： Quinn LS,Haugk KL

更新日期：1996-07-01 00:00:00

abstract：:Nidogen/entactin is a Mr = 150,000 glycoprotein which is present within basement membranes in a noncovalent stable complex with laminin. We have studied the effects of nidogen/entactin complexed or not with laminin on attachment, spreading, and functions of adult rat hepatocytes in primary culture. Freshly isolated he...

journal_title：Journal of cellular physiology

authors： Levavasseur F,Mayer U,Guillouzo A,Clement B

更新日期：1994-11-01 00:00:00

abstract：:The effects of kinin B1 receptor (B1 R) deletion were examined on femur bone regeneration in streptozotocin (STZ)-type 1 diabetes. Diabetes induction in wild-type C57/BL6 (WTC57BL6) mice led to decrease in body weight and hyperglycemia, compared to the non-diabetic group of the same strain. The lack of B1 R did not af...

journal_title：Journal of cellular physiology

authors： Cignachi NP,Pesquero JB,Oliveira RB,Etges A,Campos MM

更新日期：2015-12-01 00:00:00

abstract：:The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 +-activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human artic...

journal_title：Journal of cellular physiology

authors： Diaz-Romero J,Nesic D

更新日期：2017-08-01 00:00:00

abstract：:The human chronic myeloid leukemia cell line K562 acquires several megakaryoblastoid features when cultured in the presence of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We observed strongly increased secretion of several proteins into the culture media of K562 cells within a few hours of TPA trea...

journal_title：Journal of cellular physiology

authors： Alitalo R,Andersson LC,Tapiovaara H,Sistonen L,Vaheri A,Stephens R

更新日期：1989-07-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) promotes bone formation by stimulating proliferation and differentiation of osteoblasts. Bone sialoprotein (BSP), is thought to function in the initial mineralization of bone, is selectively expressed by differentiated osteoblast. To determine the molecular mechanism of IGF-I regul...

journal_title：Journal of cellular physiology

authors： Nakayama Y,Nakajima Y,Kato N,Takai H,Kim DS,Arai M,Mezawa M,Araki S,Sodek J,Ogata Y

更新日期：2006-08-01 00:00:00

abstract：:The role of diacylglycerol (DAG) in hormonal induction of S phase was investigated in primary cultures of rat hepatocytes. In this model, several agonists that bind to G protein-coupled receptors act as comitogens when added to the cells soon after plating (i.e., in Go/early Gl phase), while the cells are most respons...

journal_title：Journal of cellular physiology

authors： Dajani OF,Sandnes D,Melien O,Rezvani F,Nilssen LS,Thoresen GH,Christoffersen T

更新日期：1999-08-01 00:00:00

abstract：:Type IV collagenases are secreted as latent 92 and 72 kDa proenzymes which are then activated extracellularly. The mechanisms by which they are activated in vivo are not clear. We have studied the activation of porcine endothelial cell type IV collagenases by tissue and plasma kallikrein, and found that tissue kallikr...

journal_title：Journal of cellular physiology

authors： Desrivières S,Lu H,Peyri N,Soria C,Legrand Y,Ménashi S

更新日期：1993-12-01 00:00:00

abstract：:Resistin, secreted by macrophages in tumor microenvironment, has never been investigated in pancreatic cancer models, despite a vibrant tumor microenvironment around pancreatic tumors. We evaluated serum resistin levels in healthy individuals versus pancreatic cancer patients representing different tumor grades. In vi...

journal_title：Journal of cellular physiology

authors： Zhang M,Yan L,Wang GJ,Jin R

更新日期：2019-06-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are important regulators of the dynamic development and turnover of tissues. Among FGF receptors, FGFR3 expression is confined in the intestinal crypts. We examined FGFR3-deficient mice and saw increased intestinal crypt depth but no change in villae length or in the distribution of di...

journal_title：Journal of cellular physiology

authors： Arnaud-Dabernat S,Yadav D,Sarvetnick N

更新日期：2008-07-01 00:00:00

abstract：:Proteinuria in diabetic nephropathy has been correlated with reduction in heparan sulfate proteoglycan (HSPG) content of the glomerular basement membrane. We have previously shown that the underlying mechanism probably involves reduction in the synthesis by glomerular epithelial cells. In this study we explored whethe...

journal_title：Journal of cellular physiology

authors： Kasinath BS,Grellier P,Choudhury GG,Abboud SL

更新日期：1996-04-01 00:00:00

abstract：:Both mammary gland development and mammary carcinogenesis involve extensive remodeling of the mammary gland extracellular matrix. The expression of four membrane-type matrix metalloproteinases (MT-MMPs) with matrix remodeling potential in development and tumorigenesis was evaluated by in-situ hybridization on mouse ma...

journal_title：Journal of cellular physiology

authors： Szabova L,Yamada SS,Birkedal-Hansen H,Holmbeck K

更新日期：2005-10-01 00:00:00

abstract：:Proprotein convertase subtilisin/kexin 4 (PCSK4) is implicated for sperm fertilizing ability, based on studies using Pcsk4-null mice. Herein we demonstrated proprotein convertase (PC) activity in intact sperm and acrosomal vesicles. To determine whether this activity was important for sperm fertilizing ability, a pept...

journal_title：Journal of cellular physiology

authors： Iamsaard S,Vanichviriyakit R,Hommalai G,Saewu A,Srakaew N,Withyachumnarnkul B,Basak A,Tanphaichitr N

更新日期：2011-11-01 00:00:00

abstract：:Surface membrane expression and conformational activation of CD18 integrins into an open molecular configuration play critical roles in neutrophil ligand binding, membrane attachment, spreading on the endothelium, and cell migration to sites of inflammation. Previously, we observed pseudopod retraction and concomitant...

journal_title：Journal of cellular physiology

authors： Shin HY,Simon SI,Schmid-Schönbein GW

更新日期：2008-02-01 00:00:00

abstract：:Mitofusin 2 (MFN2) is a regulatory protein participating in mitochondria dynamics, cell proliferation, death, differentiation, and so on. This study aims at revealing the functional role of MFN2 in the pluripotency maintenance and primitive differetiation of embryonic stem cell (ESCs). A dox inducible silencing and ro...

journal_title：Journal of cellular physiology

authors： Yi S,Cui C,Huang X,Yin X,Li Y,Wen J,Luan Q

更新日期：2020-02-01 00:00:00

abstract：:Exposure of neutrophils to a variety of agonists including soluble chemoattractant peptides and cytokines results in degranulation and activation of the oxidative burst (effector functions) that are required for bacterial killing. At present, the signaling pathways regulating these important functions are incompletely...

journal_title：Journal of cellular physiology

authors： Sue-A-Quan AK,Fialkow L,Vlahos CJ,Schelm JA,Grinstein S,Butler J,Downey GP

更新日期：1997-07-01 00:00:00

abstract：:Diabetic retinopathy (DR) is complication resulted from Type 2 diabetes mellitus. Accumulating evidence has proved the functions of long noncoding RNAs (lncRNAs) in the progression of DR. Recent reports exert the numerous regulatory functions of lncRNA nuclear-enriched abundant transcript 1 (NEAT1) in various diseases...

journal_title：Journal of cellular physiology

authors： Shao K,Xi L,Cang Z,Chen C,Huang S

更新日期：2020-12-01 00:00:00

abstract：:In previous studies on HeLa cells we demonstrated estrogen-responsiveness of the epidermal growth factor receptor (EGFR) gene, as 17beta-estradiol (E(2)) and selective estrogen receptor modulators (SERMs) genistein (G), daidzein (D), and 4-hydroxytamoxifen (4OH-T) modulated its transcription in a ligand- and estrogen ...

journal_title：Journal of cellular physiology

authors： Salvatori L,Caporuscio F,Coroniti G,Starace G,Frati L,Russo MA,Petrangeli E

更新日期：2009-07-01 00:00:00

abstract：:The clonal hematopoiesis when occurring without hematologic abnormalities is defined as clonal hematopoiesis of indeterminate potential (CHIP). Aging causes accumulation of somatic mutations, and hematopoietic stem cells (HSCs) can develop clonal expansion of different lineages by these mutations. CHIP has a correlati...

journal_title：Journal of cellular physiology

authors： Haybar H,Shahrabi S,Ghanavat M,Khodadi E

更新日期：2019-06-01 00:00:00

abstract：:The concentration of ATP in cysts of the brine shrimp, Artemia salina, has been studied as a function of cyst hydration. Cysts dried over CaSO4 contain 0.02 gH2O/g cysts and 0.54 +/- 0.05 (S.D.) mumoles of ATP/g dried cysts. Addition of water up to 0.05 g/g cysts produced no net change in the level of ATP during incub...

journal_title：Journal of cellular physiology

authors： Clegg JS,Cavagnaro J

更新日期：1976-06-01 00:00:00

abstract：:There is evidence that cadmium can initiate carcinogenesis. However, the underlying mechanisms remain unknown. There is also evidence that moderate centrosome amplification can initiate tumorigenesis. The present study investigated whether cadmium could trigger cell centrosome amplification, and examined the underlyin...

journal_title：Journal of cellular physiology

authors： Zhang RK,Wang P,Lu YC,Lang L,Wang L,Lee SC

更新日期：2019-08-01 00:00:00

abstract：:To test the hypothesis that football training would be accompanied by physiological adaptations and hormonal changes, we analyzed the effects of a whole football season on physical fitness and hormonal concentrations in youth football players. Male football players (n = 29, age 16.51 ± 0.7 years) in a regional profess...

journal_title：Journal of cellular physiology

authors： Muscella A,Vetrugno C,Spedicato M,Stefàno E,Marsigliante S

更新日期：2019-11-01 00:00:00

abstract：:Erythropoietin (EPO), the key hormone for erythropoiesis, also increases nitric oxide (NO) bioavailability in endothelial cells (ECs), yet the definitive mechanisms are not fully understood. Increasing evidence has demonstrated that β common receptor (βCR) plays a crucial role in EPO-mediated non-hematopoietic effects...

journal_title：Journal of cellular physiology

authors： Su KH,Shyue SK,Kou YR,Ching LC,Chiang AN,Yu YB,Chen CY,Pan CC,Lee TS

更新日期：2011-12-01 00:00:00

abstract：:Increased vascular resistance in the fetoplacental circulation is a characteristic of preeclampsia. However, the potential molecular mechanisms of this condition remain obscure. The current study aimed to determine the direct effect of the peptide antigen corresponding to the second extracellular loop of the angiotens...

journal_title：Journal of cellular physiology

authors： Zhang S,Zheng R,Yang L,Zhang X,Zuo L,Yang X,Bai K,Song L,Tian J,Yang J,Liu H

更新日期：2013-01-01 00:00:00

abstract：:The effect of cell culture age and concomitant changes in cell density on the biosynthesis of sulfated-proteoglycan by rabbit articular chondrocytes in secondary monolayer culture was studied. Low density (LD, 2 d), middle density (MD, 5-7 d), and high density (HD, 12-15 d) cultures demonstrated changes in cellular mo...

journal_title：Journal of cellular physiology

authors： Malemud CJ,Papay RS

更新日期：1984-12-01 00:00:00

abstract：:Pterostilbene (PTS), a naturally occurring stilbene, confers protection against oxidative and cytokine stress induced pancreatic β-cell apoptosis in vitro and in vivo. To provide insights into the molecular mechanism, we performed a proteomic study on the pancreas of PTS-treated diabetic mice using electrospray ioniza...

journal_title：Journal of cellular physiology

authors： Dornadula S,Thiruppathi S,Palanisamy R,Umapathy D,Suzuki T,K Mohanram R

更新日期：2019-03-01 00:00:00