Abstract:
:Both mammary gland development and mammary carcinogenesis involve extensive remodeling of the mammary gland extracellular matrix. The expression of four membrane-type matrix metalloproteinases (MT-MMPs) with matrix remodeling potential in development and tumorigenesis was evaluated by in-situ hybridization on mouse mammary gland sections. MT1-MMP and MT3-MMP were found in the mammary stroma mainly around epithelial structures in both developing and mature mammary gland. In contrast, MT2-MMP was found exclusively in the mammary epithelium. Lactating gland expressed none of the examined MT-MMPs. Mammary gland tumors expressed MT1-MMP, MT2-MMP, and MT3-MMP while MT4-MMP was not expressed in any developmental or cancerous stage analyzed here. Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Szabova L,Yamada SS,Birkedal-Hansen H,Holmbeck Kdoi
10.1002/jcp.20385keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
123-32issue
1eissn
0021-9541issn
1097-4652journal_volume
205pub_type
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