Targeting IL-34 in inflammatory autoimmune diseases.

abstract：:Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses...

journal_title：Journal of cellular physiology

authors： Giordano A,Rossi A,Romano G,Bagella L

更新日期：2007-11-01 00:00:00

abstract：:Syndecan-1 belongs to a family of transmembrane proteoglycans, acts as a coreceptor for growth factor binding, as well as cell-matrix and cell-cell interactions, and is induced in smooth muscle cells (SMCs) following balloon catheter injury. In this report, we investigated syndecan-1 expression in SMCs in response to ...

journal_title：Journal of cellular physiology

authors： Julien MA,Haller CA,Wang P,Wen J,Chaikof EL

更新日期：2007-04-01 00:00:00

abstract：:Chronic hyperglycemia and activation of receptor for advanced glycation end products (RAGE) are known risk factors for microvascular disease development in diabetic retinopathy. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin (TRX), plays a causative role in diabetes and its...

journal_title：Journal of cellular physiology

authors： Perrone L,Devi TS,Hosoya K,Terasaki T,Singh LP

更新日期：2009-10-01 00:00:00

abstract：:Extracellular high K(+) (75 mM) increased intracellular Ca(2+) concentrations in cultured rat hippocampal astrocytes, and the Ca(2+) rise was abolished by deleting extracellular Ca(2+) or cadmium, a non-selective inhibitor of voltage-dependent calcium channels (VDCCs). In the reverse transcription-polymerase chain rea...

journal_title：Journal of cellular physiology

authors： Yaguchi T,Nishizaki T

更新日期：2010-11-01 00:00:00

abstract：:Hemopoietic cell proliferation is controlled by a set of polypeptide growth factors and regulatory molecules that bind to cell surface receptors inducing cellular responses. Maintenance of a viable state, cell growth, DNA synthesis and mitosis are basic properties of proliferating cells, but links between growth facto...

journal_title：Journal of cellular physiology

authors： Berridge MV,Horsfield JA,Tan AS

更新日期：1995-06-01 00:00:00

abstract：:Using methods designed for isolation of mutants defective in receptor-mediated endocytosis, a novel L-cell mutant was obtained that exhibits resistance to three different protein toxins as well as alterations in secretion. This mutant, LEFIC, is resistant to modeccin, Pseudomonas exotoxin, and ricin. These toxins, whi...

journal_title：Journal of cellular physiology

authors： Laurie SM,Robbins AR

更新日期：1991-05-01 00:00:00

abstract：:The concentration of ATP in cysts of the brine shrimp, Artemia salina, has been studied as a function of cyst hydration. Cysts dried over CaSO4 contain 0.02 gH2O/g cysts and 0.54 +/- 0.05 (S.D.) mumoles of ATP/g dried cysts. Addition of water up to 0.05 g/g cysts produced no net change in the level of ATP during incub...

journal_title：Journal of cellular physiology

authors： Clegg JS,Cavagnaro J

更新日期：1976-06-01 00:00:00

abstract：:A neuroblastoma cell line was assessed for its capacity to bind tetanus toxin (TT) by using immunofluorescence and flow cytometry to analyze cells on a single cell basis. A clone of Neuro 2a, N2AB-1, was shown to bind variable amounts of TT per cell and this binding could be saturated by increasing doses of the toxin....

journal_title：Journal of cellular physiology

authors： Notter MF,Leary JF

更新日期：1985-12-01 00:00:00

abstract：:Transient Receptor Potential Canonical (TRPC) channels are implicated in modulating neurite outgrowth. The expression pattern of TRPCs changes significantly during brain development, suggesting that fine-tuning TRPC expression may be important for orchestrating neuritogenesis. To study how alterations in the TRPC expr...

journal_title：Journal of cellular physiology

authors： Kumar S,Chakraborty S,Barbosa C,Brustovetsky T,Brustovetsky N,Obukhov AG

更新日期：2012-04-01 00:00:00

abstract：:Cervical cancer is a deadly gynecological malignancy in need of innovative treatment strategies. Emerging preclinical data has suggested the benefits of nanocarriers over the traditional chemotherapy for cancer treatment. In particular, gold nanoparticles are gaining popularity due to gold's inert nature, limited side...

journal_title：Journal of cellular physiology

authors： Guan YH,Tian M,Liu XY,Wang YN

更新日期：2019-02-20 00:00:00

abstract：:The role of individual supplements necessary for the long-term self-renewal of embryonic stem (ES) cells is poorly characterized in feeder/serum-free culture systems. This study sought to characterize the relationship between the effects of glucose on ES cell proliferation and fibronectin (FN) synthesis, and to assess...

journal_title：Journal of cellular physiology

authors： Kim YH,Ryu JM,Lee YJ,Han HJ

更新日期：2010-05-01 00:00:00

abstract：:The epithelium-specific ETS (ESE)-1 transcription factor is induced in chondrocytes by interleukin-1beta (IL-1beta). We reported previously that early activation of EGR-1 by IL-1beta results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes. Here we report that ESE-1 is a pot...

journal_title：Journal of cellular physiology

authors： Peng H,Tan L,Osaki M,Zhan Y,Ijiri K,Tsuchimochi K,Otero M,Wang H,Choy BK,Grall FT,Gu X,Libermann TA,Oettgen P,Goldring MB

更新日期：2008-05-01 00:00:00

abstract：:Clinicians have observed that keloids preferentially form in body areas subject to increased skin tension. We hypothesized a difference exists in the transcriptional response of keloid fibroblasts to mechanical strain compared with normal fibroblasts. Normal and keloid fibroblasts were seeded in a device calibrated to...

journal_title：Journal of cellular physiology

authors： Wang Z,Fong KD,Phan TT,Lim IJ,Longaker MT,Yang GP

更新日期：2006-02-01 00:00:00

abstract：:Despite a high degree of structural homology and shared exchange factors, effectors and GTPase activating proteins, a large body of evidence suggests functional heterogeneity among Ras isoforms. One aspect of Ras biology that may explain this heterogeneity is the differential subcellular localizations driven by the C-...

journal_title：Journal of cellular physiology

authors： Lynch SJ,Snitkin H,Gumper I,Philips MR,Sabatini D,Pellicer A

更新日期：2015-03-01 00:00:00

abstract：:The ratio of mouse to rat albumin secreted by mouse hepatoma x rat hepatoma hybrid cells is constant (of the order of 5.0) irrespective of the total amounts produced. The present results establish for seven independent hybrid clones that the coordination in the ratio of mouse to rat product applies also at the level o...

journal_title：Journal of cellular physiology

authors： Sellem CH,Cassio D,Sala-Trepat JM,Weiss MC

更新日期：1983-05-01 00:00:00

abstract：:Epimorphin/syntaxin 2 is a high conserved and very abundant protein involved in epithelial morphogenesis in various organs. We have shown recently that epimorphin (EPM), a protein exclusively expressed on the surface of hepatic stellate cells and myofibroblasts of the liver, induces bile duct formation of hepatic stem...

journal_title：Journal of cellular physiology

authors： Jia Y,Yao H,Zhou J,Chen L,Zeng Q,Yuan H,Shi L,Nan X,Wang Y,Yue W,Pei X

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Cigarette smoke exposure, increasing Toll-like receptor 4 (TLR4) and reactive oxygen species (ROS), promotes inflammatory responses in airway epithelial cells. Chronic inflammation, microRNA (miRNA), and oxidative stress are associated with cancer development. AIMS:The present study was aimed to explore whe...

journal_title：Journal of cellular physiology

authors： Pace E,Di Vincenzo S,Di Salvo E,Genovese S,Dino P,Sangiorgi C,Ferraro M,Gangemi S

更新日期：2019-12-01 00:00:00

abstract：:Baclofen is used clinically as a drug that treats spasticity, which is a syndrome characterized by excessive contraction of the muscles and hyperflexia in the central nervous system (CNS), by activating GABA(B) receptors (GABA(B)Rs). Baclofen was recently reported to desensitize chemokine receptors and to suppress inf...

journal_title：Journal of cellular physiology

authors： Huang S,Mao J,Wei B,Pei G

更新日期：2015-07-01 00:00:00

abstract：:Cardiac hypertrophy (CH) has become a huge threat to human health. Recent years, long noncoding RNAs (lncRNAs) have been studied in human diseases, including CH. According to bioinformatics analysis, 10 lncRNAs possibly involved in the progression of CH were screened out. Among which, lncRNA SYNE1 antisense RNA 1 (SYN...

journal_title：Journal of cellular physiology

authors： Wang Y,Cao R,Yang W,Qi B

更新日期：2019-08-01 00:00:00

abstract：:Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin-13/APJ confers a proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed to investig...

journal_title：Journal of cellular physiology

authors： He L,Zhou Q,Huang Z,Xu J,Zhou H,Lv D,Lu L,Huang S,Tang M,Zhong J,Chen JX,Luo X,Li L,Chen L

更新日期：2019-06-01 00:00:00

abstract：:When HL60 cells are exposed to 1,25-dihydroxyvitamin D3 (1,25D3), they undergo changes approximating the phenotype of the monocyte. Little is known, however, about the regulation and the mechanisms of this transition. It was previously noted that DNA binding by the Sp1 transcription factor in nuclear extracts of HL60 ...

journal_title：Journal of cellular physiology

authors： Rao J,Zhang F,Donnelly RJ,Spector NL,Studzinski GP

更新日期：1998-05-01 00:00:00

abstract：:We examined the role of superoxide in the increase in intracellular pH (pHi) of human histiocytic leukemia U937 cells treated with 4 beta-phorbol-12,13-didecanoate (4 beta-PDD) or serum. 4 beta-PDD or serum induced a rapid increase in pHi, and antioxidants such as superoxide dismutase (SOD), vitamin E, and butylated h...

journal_title：Journal of cellular physiology

authors： Shibanuma M,Kuroki T,Nose K

更新日期：1988-08-01 00:00:00

abstract：:Estrogen-responsive genes often have an estrogen response element (ERE) positioned next to activator protein-1 (AP-1) binding sites. Considering that the interaction between ERE and AP-1 elements has been described for the modulation of bone-specific genes, we investigated the 17-beta-estradiol responsiveness and the ...

journal_title：Journal of cellular physiology

authors： Lambertini E,Tavanti E,Torreggiani E,Penolazzi L,Gambari R,Piva R

更新日期：2008-07-01 00:00:00

abstract：:We examined the behavior of the transcription factor Max during retrograde neuronal degeneration of retinal ganglion cells. Using immunohistochemistry, we found a progressive redistribution of full-length Max from the nucleus to the cytoplasm and dendrites of the ganglion cells following axon damage. Then, the axotomi...

journal_title：Journal of cellular physiology

authors： Petrs-Silva H,de Freitas FG,Linden R,Chiarini LB

更新日期：2004-02-01 00:00:00

abstract：:Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological ...

journal_title：Journal of cellular physiology

authors： Wang H,Wang Q,Yang M,Yang L,Wang W,Ding H,Zhang D,Xu J,Tang X,Ding H,Wang Q

更新日期：2018-02-01 00:00:00

abstract：:In this study, we compared qualitative and quantitative changes in the lateral mobility of phospholipid molecules in the plasma membrane of intact cells under various conditions of specific interaction of integrins in the cell membrane with two extracellular matrix (ECM) components viz. fibronectin (FN) and laminin (L...

journal_title：Journal of cellular physiology

authors： Ramprasad OG,Rangaraj N,Srinivas G,Thiery JP,Dufour S,Pande G

更新日期：2008-05-01 00:00:00

abstract：:Signal transduction of fibroblast growth factor (FGF) receptors is known to involve tyrosine phosphorylation of several substrates, including Grb2, phospholipase C-gamma, and phosphatidylinositol 3-kinase, whereas the role of G-proteins in FGF receptor signaling is controversial. In the present study we investigated t...

journal_title：Journal of cellular physiology

authors： Piiper A,Stryjek-Kaminska D,Gebhardt R,Zeuzem S

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effect of polo-like kinase 1 (PLK1) inhibition on cisplatin (DDP)-resistant gastric cancer (GC) cells. METHODS:The transcriptional level of PLK1 was measured by quantitative reverse-transcription polymerase chain reaction. Expressions of PLK1 and its downstream mediators as...

journal_title：Journal of cellular physiology

authors： Chen Z,Chai Y,Zhao T,Li P,Zhao L,He F,Lang Y,Qin J,Ju H

更新日期：2019-05-01 00:00:00

abstract：:The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 +-activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human artic...

journal_title：Journal of cellular physiology

authors： Diaz-Romero J,Nesic D

更新日期：2017-08-01 00:00:00

abstract：:Histone deacetylases (HDACs) play a crucial role in the regulation of gene expression through remodeling of chromatin structures. However, the molecular mechanisms involved in this event remain unknown. In this study, we sought to examine whether HDAC inhibition-mediated protective effects involved HDAC4 sumoylation, ...

journal_title：Journal of cellular physiology

authors： Du J,Zhang L,Zhuang S,Qin GJ,Zhao TC

更新日期：2015-06-01 00:00:00