Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy.

Abstract:

:Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment.

journal_name

J Cell Physiol

authors

Giordano A,Rossi A,Romano G,Bagella L

doi

10.1002/jcp.21225

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

403-6

issue

2

eissn

0021-9541

issn

1097-4652

journal_volume

213

pub_type

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