Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells.

abstract：:Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP and UTP endorse [Ca2+ ]i accumulation and growth of DDR-2/α-SMA-expressing myofibroblasts from adult rat ventricles via P2Y4 and P2Y2 receptors activation, resp...

journal_title：Journal of cellular physiology

authors： Certal M,Vinhas A,Barros-Barbosa A,Ferreirinha F,Costa MA,Correia-de-Sá P

更新日期：2017-06-01 00:00:00

abstract：:Liver regeneration involves not only hepatocyte replication but progenitor aggregation and scarring. Partial hepatectomy (PH), an established model for liver regeneration, reactivates transforming growth factor-β (TGF-β) signaling. Hepatic stellate cells (HSCs) are primarily responding cells for TGF-β and resident in ...

journal_title：Journal of cellular physiology

authors： Chen Z,Wan L,Jin X,Wang W,Li D

更新日期：2020-03-01 00:00:00

abstract：:Photoperiod regulates the seasonal reproductive rhythms of mammals by influencing the development and function of sexual organs; however, the underlying mechanism remains unclear. We examined the morphology and functioning of the main sex organs of striped dwarf hamsters (Cricetulus barabensis) under different photope...

journal_title：Journal of cellular physiology

authors： Mou J,Xu J,Wang Z,Wang C,Yang X,Wang X,Xue H,Wu M,Xu L

更新日期：2021-03-01 00:00:00

abstract：:The coupled action of the Na(+)/H(+) exchanger NHE1 and the HCO3(-)/Cl(-) exchanger AE2 constitutes the principal mechanism for acute correction of decreased cell volume in mammalian somatic cells, while, when acting separately, they regulate intracellular pH. It was previously found that AE2 becomes inactivated durin...

journal_title：Journal of cellular physiology

authors： Zhou C,Fitzharris G,Alper SL,Baltz JM

更新日期：2013-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a potent mediator of endothelial proliferation and migration, has an important role also in brain edema formation during hypoxia and ischemia. VEGF binds to the tyrosine kinase receptors Flt-1 and Flk-1. Yet, their relative importance for hypoxia-induced hyperpermeability is ...

journal_title：Journal of cellular physiology

authors： Vogel C,Bauer A,Wiesnet M,Preissner KT,Schaper W,Marti HH,Fischer S

更新日期：2007-07-01 00:00:00

abstract：:Four cell lines, named nonparenchymal 11 (NP11), NP26, NP31, and NP32, were established from sinusoidal endothelial cells (SECs) of rat liver. They still retained expression of receptors for vascular endothelial growth factor (VEGF), Fit-1, and kinase domain-containing receptor (KDR). NP31 and NP32 turned out to be in...

journal_title：Journal of cellular physiology

authors： Maru Y,Yamaguchi S,Takahashi T,Ueno H,Shibuya M

更新日期：1998-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proli...

journal_title：Journal of cellular physiology

authors： Chen Y,Zhao ZX,Huang F,Yuan XW,Deng L,Tang D

更新日期：2019-04-01 00:00:00

abstract：:Acidic pH of the Golgi lumen is known to be crucial for correct glycosylation, transport and sorting of proteins and lipids during their transit through the organelle. To better understand why Golgi acidity is important for these processes, we have examined here the most pH sensitive events in N-glycosylation by seque...

journal_title：Journal of cellular physiology

authors： Rivinoja A,Hassinen A,Kokkonen N,Kauppila A,Kellokumpu S

更新日期：2009-07-01 00:00:00

abstract：:To analyze transforming growth factor-beta (TGF-beta) response during MCF-7 cell progression, early passage (MCF-7E, < 200 passage) and late passage (MCF-7L, > 500 passage) cells were compared. MCF-7E cells showed an IC50 of approximately 10 ng/ml of TGF-beta1, whereas MCF-7L cells were insensitive. MCF-7E cells conta...

journal_title：Journal of cellular physiology

authors： Ko Y,Banerji SS,Liu Y,Li W,Liang J,Soule HD,Pauley RJ,Willson JK,Zborowska E,Brattain MG

更新日期：1998-08-01 00:00:00

abstract：:In vitro generation of HSCs from pluripotent stem cells (PSCs) can be regarded as novel therapeutic approaches for replacing bone marrow (BM) transplantation without immune rejection or graft versus host disease(GVHD). To date, many differentiation approaches have been evaluated in terms of directing PSCs toward diffe...

journal_title：Journal of cellular physiology

authors： Shan W,Wang B,Xu Y,Li X,Li X,Wang H,Lin Y,Tie R,Zhao Q,Wang J,Zheng W,Hu Y,Shi J,Yu X,Huang H

更新日期：2018-01-31 00:00:00

abstract：:Small hepatocytes (SHs) are a subpopulation of hepatocytes that have high growth potential in culture and can differentiate into mature hepatocytes (MHs). The activin (Act)/follistatin (Fst) system critically contributes to homeostasis of cell growth in the normal liver. ActA and ActB consist of two disulfide-linked I...

journal_title：Journal of cellular physiology

authors： Ooe H,Chen Q,Kon J,Sasaki K,Miyoshi H,Ichinohe N,Tanimizu N,Mitaka T

更新日期：2012-06-01 00:00:00

abstract：:The epithelium-specific ETS (ESE)-1 transcription factor is induced in chondrocytes by interleukin-1beta (IL-1beta). We reported previously that early activation of EGR-1 by IL-1beta results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes. Here we report that ESE-1 is a pot...

journal_title：Journal of cellular physiology

authors： Peng H,Tan L,Osaki M,Zhan Y,Ijiri K,Tsuchimochi K,Otero M,Wang H,Choy BK,Grall FT,Gu X,Libermann TA,Oettgen P,Goldring MB

更新日期：2008-05-01 00:00:00

abstract：:The role of calmodulin (CaM) in modulating calcium (Ca) uptake by sarcoplasmic reticulum (SR) of vascular smooth muscle was studied in saponin skinned strips of rat caudal artery. Exogenous CaM concentrations ranging from 0.3-1.8 microM did not statistically change the steady state MgATP-dependent Ca content, the MgAT...

journal_title：Journal of cellular physiology

authors： Stout MA,Silver PJ

更新日期：1992-10-01 00:00:00

abstract：:The expression of a set of cell cycle dependent (CCD) genes (c-fos, c-myc, ornithine decarboxylase (ODC), and thymidine kinase (TK)) was comparatively studied in cultured arterial smooth muscle cells (SMC) during exit from quiescence and exponential proliferation. These genes, which were not expressed in quiescent SMC...

journal_title：Journal of cellular physiology

authors： Campan M,Desgranges C,Gadeau AP,Millet D,Belloc F

更新日期：1992-03-01 00:00:00

abstract：:In response to metabolic stress, GLUT4, the most abundant glucose transporter, translocates from intracellular vesicles to the plasma membrane. This appears to play an important role in protecting cardiac myocytes from ischemic injury. To investigate the precise mechanisms of GLUT4 translocation in cardiomyocytes, we ...

journal_title：Journal of cellular physiology

authors： Horie T,Ono K,Nagao K,Nishi H,Kinoshita M,Kawamura T,Wada H,Shimatsu A,Kita T,Hasegawa K

更新日期：2008-06-01 00:00:00

abstract：:Addition of bombesin in the presence of either forskolin or cholera toxin caused a marked (4-6 fold) enhancement of cAMP accumulation in Swiss 3T3 cells. This effect was time and concentration dependent, induced by various bombesin-like peptides and blocked by a bombesin antagonist. Enhancement of cAMP accumulation by...

journal_title：Journal of cellular physiology

authors： Millar JB,Rozengurt E

更新日期：1988-11-01 00:00:00

abstract：:miR-222 participates in many cardiovascular diseases, but its effect on cardiac remodeling induced by diabetes is unclear. This study evaluated the functional role of miR-222 in cardiac fibrosis in diabetic mice. Streptozotocin (STZ) was used to establish a type 1 diabetic mouse model. After 10 weeks of STZ injection,...

journal_title：Journal of cellular physiology

authors： Wang Z,Wang Z,Gao L,Xiao L,Yao R,Du B,Li Y,Wu L,Liang C,Huang Z,Li P,Zhang Y

更新日期：2020-03-01 00:00:00

abstract：:Insulin-like growth factor-I receptor (IGF-IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin-coated vescicles that transfer the receptor to th...

journal_title：Journal of cellular physiology

authors： Carelli S,Di Giulio AM,Paratore S,Bosari S,Gorio A

更新日期：2006-08-01 00:00:00

abstract：:Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clinical problem whose pathophysiology is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human re...

journal_title：Journal of cellular physiology

authors： Andreucci M,Faga T,Pisani A,Serra R,Russo D,De Sarro G,Michael A

更新日期：2018-05-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to be both an intercellular and intracellular messenger. We propose here that exogenous NO induces chemotactic locomotion of human neutrophils. Indeed, when human neutrophils were placed in a gradient of a nitric oxide donor (S-nitroso-N-acetylpenicillamine; SNAP), a directed locomotio...

journal_title：Journal of cellular physiology

authors： Beauvais F,Michel L,Dubertret L

更新日期：1995-12-01 00:00:00

abstract：:The C-terminal region of parathyroid hormone-related protein (PTHrP) containing the sequence (107-111) appears to be a potent inhibitor of osteoclastic bone resorption. In the present study, we have investigated the effect of human (h)PTHrP (107-139) and hPTHrP (107-111)NH2 on the proliferation of osteoblastic rat ost...

journal_title：Journal of cellular physiology

authors： Valín A,García-Ocaña A,De Miguel F,Sarasa JL,Esbrit P

更新日期：1997-02-01 00:00:00

abstract：:Although muscle satellite cells were identified almost 40 years ago, little is known about the induction of their proliferation and differentiation in response to physiological/pathological stimuli or to growth factors/cytokines. In order to investigate the role of the insulin-like growth factor (IGF)/IGF binding prot...

journal_title：Journal of cellular physiology

authors： Foulstone EJ,Savage PB,Crown AL,Holly JM,Stewart CE

更新日期：2003-04-01 00:00:00

abstract：:Mouse epidermal cells can be grown as a proliferating monolayer in medium containing 0.02-0.1 mM calcium. Terminal differentiation of these cells with formation of cornified cells and cell death is induced by elevating calcium in the medium to greater than 0.1 mM. A variety of agents were studied as potential modifier...

journal_title：Journal of cellular physiology

authors： Hennings H,Holbrook KA,Yuspa SH

更新日期：1983-09-01 00:00:00

abstract：:Zearalenone is a mycotoxin produced mainly by Fusarium. There are numerous incidences of mycotoxicosis in laboratory and domestic animals, especially in pigs. However, little is known about molecular mechanisms of zearalenone toxicity. Granulosa cells are the maximal cell population in follicles, and they play an esse...

journal_title：Journal of cellular physiology

authors： Zhu L,Yuan H,Guo C,Lu Y,Deng S,Yang Y,Wei Q,Wen L,He Z

更新日期：2012-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related death worldwide. About 1.8 million new cases were reported in 2018. Accordingly, there is an urgent need for development of effective strategies to lower the mortality and morbidity originated from this malignancy. MicroRNAs ...

journal_title：Journal of cellular physiology

authors： Anvarnia A,Mohaddes-Gharamaleki F,Asadi M,Akbari M,Yousefi B,Shanehbandi D

更新日期：2019-12-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-Smads) can be classi...

journal_title：Journal of cellular physiology

authors： Miyazono K,Kusanagi K,Inoue H

更新日期：2001-06-01 00:00:00

abstract：:Glioblastoma, the most common brain tumor, is characterized by high proliferation rate, invasion, angiogenesis, and chemo- and radio-resistance. One of most remarkable feature of glioblastoma is the switch toward a glycolytic energetic metabolism that leads to high glucose uptake and consumption and a strong productio...

journal_title：Journal of cellular physiology

authors： Cimini A,d'Angelo M,Benedetti E,D'Angelo B,Laurenti G,Antonosante A,Cristiano L,Di Mambro A,Barbarino M,Castelli V,Cinque B,Cifone MG,Ippoliti R,Pentimalli F,Giordano A

更新日期：2017-02-01 00:00:00

abstract：:Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

journal_title：Journal of cellular physiology

authors： Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

更新日期：2011-11-01 00:00:00

abstract：:Balb/C3T3 cells entered the quiescent Go state following serum deprivation. On addition of fresh serum, more than 95% of the culture resumed growth, but with asynchronous kinetics. If hydroxyurea were added just before the first cells reached S phase, at at least 90% of the cells accumulated at the Gl/S border over th...

journal_title：Journal of cellular physiology

authors： Dooley DC,Ozer HL

更新日期：1977-02-01 00:00:00

abstract：:The platelet-derived growth factor (PDGF) binds via a defined amino acid sequence to heparin (Fager et al., 1992, In Vitro Cell. Dev. Biol., 28A:176-180) and the protein moiety of low density lipoproteins (LDL; apo B-100) via a similar sequence to chondroitin sulfate (Camejo et al., 1988, Arteriosclerosis Thromb., 8:3...

journal_title：Journal of cellular physiology

authors： Fager G,Camejo G,Olsson U,Ostergren-Lundén G,Lustig F,Bondjers G

更新日期：1995-05-01 00:00:00