Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases.

abstract：:Extracellular ATP and other nucleotides induce autocrine and/or paracrine purinergic signalling via activation of the P2 receptors on the cell surface, which represents one of the most common signalling mechanisms. Mesenchymal stem cells (MSC) are a type of multipotent adult stem cells that have many promising applica...

journal_title：Journal of cellular physiology

authors： Jiang LH,Hao Y,Mousawi F,Peng H,Yang X

更新日期：2017-02-01 00:00:00

abstract：:Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP and UTP endorse [Ca2+ ]i accumulation and growth of DDR-2/α-SMA-expressing myofibroblasts from adult rat ventricles via P2Y4 and P2Y2 receptors activation, resp...

journal_title：Journal of cellular physiology

authors： Certal M,Vinhas A,Barros-Barbosa A,Ferreirinha F,Costa MA,Correia-de-Sá P

更新日期：2017-06-01 00:00:00

abstract：:The level of 1,25(OH)2D3 receptors in cultured mouse osteoblast-like (OB) cells is modulated by the rate of cell proliferation. We have studied two 1,25(OH)2D3-induced bioresponses to ascertain whether the changes in receptor levels during growth in culture alter cell responsiveness. Nuclear receptor levels were high ...

journal_title：Journal of cellular physiology

authors： Chen TL,Li JM,Ye TV,Cone CM,Feldman D

更新日期：1986-01-01 00:00:00

abstract：:Cells from kidney proximal tubules have been successfully isolated, characterized, and cultured from male Fischer 344 rats between 150-400 g using a two-step collagenase perfusion. The cells undergo high levels of DNA synthesis and mitosis in both serum free media (with an without hormone supplementation) and media co...

journal_title：Journal of cellular physiology

authors： Rosenberg MR,Michalopoulos G

更新日期：1987-04-01 00:00:00

abstract：:This study aimed at investigating the expression and function of uracil nucleotide-sensitive receptors (P2Y(2), P2Y(4), and P2Y(6)) on osteogenic differentiation of human bone marrow stromal cells (BMSCs) in culture. Bone marrow specimens were obtained from postmenopausal female patients (68 ± 5 years old, n = 18) und...

journal_title：Journal of cellular physiology

authors： Noronha-Matos JB,Costa MA,Magalhães-Cardoso MT,Ferreirinha F,Pelletier J,Freitas R,Neves JM,Sévigny J,Correia-de-Sá P

更新日期：2012-06-01 00:00:00

abstract：:Surface membrane expression and conformational activation of CD18 integrins into an open molecular configuration play critical roles in neutrophil ligand binding, membrane attachment, spreading on the endothelium, and cell migration to sites of inflammation. Previously, we observed pseudopod retraction and concomitant...

journal_title：Journal of cellular physiology

authors： Shin HY,Simon SI,Schmid-Schönbein GW

更新日期：2008-02-01 00:00:00

abstract：:Simian Virus 40 (SV40), a monkey polyomavirus, was administered to human populations by early anti-poliomylitis vaccines contaminated by this small DNA tumor virus. Data on SV40 infection in humans remain controversial. Elderly subjects represent an interesting cohort to investigate, because they were not immunized wi...

journal_title：Journal of cellular physiology

authors： Mazzoni E,Guerra G,Casali MV,Pietrobon S,Bononi I,Puozzo A,Tagliapietra A,Nocini PF,Tognon M,Martini F

更新日期：2017-01-01 00:00:00

abstract：:Podocyte injury is a critical factor for the initiation and progression of diabetic kidney disease (DKD). However, the underlying mechanisms of podocyte injury in DKD have not been completely elucidated. Studies suggested that intracellular cholesterol accumulation was correlated with podocyte injury, but the cause of...

journal_title：Journal of cellular physiology

authors： Hu J,Yang Q,Chen Z,Liang W,Feng J,Ding G

更新日期：2019-12-01 00:00:00

abstract：:Osteosarcoma is the most common malignant primary bone tumor in children and adolescents. The clinical outcome for osteosarcoma remains discouraging despite aggressive surgery and intensive radiotherapy and chemotherapy regimens. Thus, novel therapeutic approaches are needed. Previously, we have shown that inorganic p...

journal_title：Journal of cellular physiology

authors： Spina A,Sorvillo L,Di Maiolo F,Esposito A,D'Auria R,Di Gesto D,Chiosi E,Naviglio S

更新日期：2013-01-01 00:00:00

abstract：:Ephrin A1 has a role in a variety of biological events, including cell proliferation, differentiation, migration, and angiogenesis. Ephrin A1 expression is abundant in trophoblasts and endometrial cells during the implantation period; however, its intracellular activities have not yet been reported in bovine endometri...

journal_title：Journal of cellular physiology

authors： Lim W,Bae H,Bazer FW,Song G

更新日期：2019-04-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are clonogenic, self-renewing, and multi-potential DPSCs capable of differentiating into osteoblasts. In this study, primary cell cultures were obtained from human dental pulp tissue of developing third molars, and flow cytometry was used to sort the subpopulation of DPSCs with STRO-1 an...

journal_title：Journal of cellular physiology

authors： Huang CH,Tseng WY,Yao CC,Jeng JH,Young TH,Chen YJ

更新日期：2010-10-01 00:00:00

abstract：:Despite a high degree of structural homology and shared exchange factors, effectors and GTPase activating proteins, a large body of evidence suggests functional heterogeneity among Ras isoforms. One aspect of Ras biology that may explain this heterogeneity is the differential subcellular localizations driven by the C-...

journal_title：Journal of cellular physiology

authors： Lynch SJ,Snitkin H,Gumper I,Philips MR,Sabatini D,Pellicer A

更新日期：2015-03-01 00:00:00

abstract：:Using S1 nuclease protection assays, we have examined the representation of cell cycle-dependent H4 histone RNAs in the nuclear matrix and nonmatrix nuclear fractions of human cells. Cytoplasmic and nuclear fractions were prepared from exponentially growing HeLa S3 cells by double detergent (sodium deoxycholate and NP...

journal_title：Journal of cellular physiology

authors： Bandyopadhyay R,Stein G,Stein J

更新日期：1986-08-01 00:00:00

abstract：:Generation of fully functional hematopoietic multipotent progenitor (MPP) cells from human pluripotent stem cells (hPSCs) has a great therapeutic potential to provide an unlimited cell source for treatment of hematological disorders. We previously demonstrated that CD34(+) CD31(+) CD144(+) population derived from hPSC...

journal_title：Journal of cellular physiology

authors： Bai H,Liu Y,Xie Y,Hoyle DL,Brodsky RA,Cheng L,Cheng T,Wang ZZ

更新日期：2016-05-01 00:00:00

abstract：:The role of platelet-derived growth factor (PDGF) in the control of smooth muscle cell (SMC) differentiation was explored in vitro by examining its effects on expression of the smooth muscle (SM) specific contractile protein SM alpha actin in cultured rat aortic SMC. Quiescent, postconfluent SMC express maximal levels...

journal_title：Journal of cellular physiology

authors： Blank RS,Owens GK

更新日期：1990-03-01 00:00:00

abstract：:Cover: Diagram illustrating the chromatic median analysis. See article by Pliss et al. on pages 427-439. ...

journal_title：Journal of cellular physiology

authors：

更新日期：2015-02-01 00:00:00

abstract：:Resistance to conventional chemotherapy remains a major cause of cancer relapse and cancer-related deaths. Therefore, there is an urgent need to overcome resistance barriers. To improve cancer treatment approaches, it is critical to elucidate the basic mechanisms underlying drug resistance. Increasingly, the mechanism...

journal_title：Journal of cellular physiology

authors： Naghizadeh S,Mohammadi A,Duijf PHG,Baradaran B,Safarzadeh E,Cho WC,Mansoori B

更新日期：2020-10-01 00:00:00

abstract：:Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epithelial-to-mesenchymal transition (EMT). We developed a model system t...

journal_title：Journal of cellular physiology

authors： Fritz AJ,Hong D,Boyd J,Kost J,Finstaad KH,Fitzgerald MP,Hanna S,Abuarqoub AH,Malik M,Bushweller J,Tye C,Ghule P,Gordon J,Frietze S,Zaidi SK,Lian JB,Stein JL,Stein GS

更新日期：2020-10-01 00:00:00

abstract：:We have investigated the role of the plasminogen activation cascade in skeletal muscle differentiation. Migrating, undifferentiated myoblasts express urokinase plasminogen activator (uPA) and its cell surface receptor (uPAR). Consequently, uPA is localized predominantly to the cell surface. Preventing uPA from associa...

journal_title：Journal of cellular physiology

authors： Wells JM,Strickland S

更新日期：1997-05-01 00:00:00

abstract：:Signal transduction of fibroblast growth factor (FGF) receptors is known to involve tyrosine phosphorylation of several substrates, including Grb2, phospholipase C-gamma, and phosphatidylinositol 3-kinase, whereas the role of G-proteins in FGF receptor signaling is controversial. In the present study we investigated t...

journal_title：Journal of cellular physiology

authors： Piiper A,Stryjek-Kaminska D,Gebhardt R,Zeuzem S

更新日期：1996-04-01 00:00:00

abstract：:The knowledge of transforming growth factor (TGF)-beta receptors has greatly progressed in the recent years. TGF-beta receptors type I and II have been implicated in the modulation of cell proliferation, whereas type III (betaglycan) may act as a component presenting TGF-beta to its signaling receptors. In addition, f...

journal_title：Journal of cellular physiology

authors： Vivien D,Petitfrère E,Martiny L,Sartelet H,Galéra P,Haye B,Pujol JP

更新日期：1993-06-01 00:00:00

abstract：:The cholinergic system plays a crucial role in modulating in the central nervous system physiological responses such as neurogenesis, neuronal differentiation, synaptic plasticity, and neuroprotection. In a recent study, we showed that Oxotremorine-M, a non-selective muscarinic acetylcholine receptor agonist, is able ...

journal_title：Journal of cellular physiology

authors： Frinchi M,Scaduto P,Cappello F,Belluardo N,Mudò G

更新日期：2018-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, an...

journal_title：Journal of cellular physiology

authors： Blanco FJ,Santibanez JF,Guerrero-Esteo M,Langa C,Vary CP,Bernabeu C

更新日期：2005-08-01 00:00:00

abstract：:Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene. RA lowered RAR alpha transcript and protein, increased RAR beta transcripts, and had no effect on RAR gamma. H-ras transformation downregulated RAR expression and...

journal_title：Journal of cellular physiology

authors： De Luca LM,Scita G,Takatsuka J

更新日期：1997-11-01 00:00:00

abstract：:We have previously demonstrated that kidney embryonic structures are present in rats, and are still developing until postnatal Day 20. Consequently, at postnatal Day 10, the rat renal papilla contains newly formed collecting duct (CD) cells and others in a more mature stage. Performing primary cultures, combined with ...

journal_title：Journal of cellular physiology

authors： Del Valle Guaytima E,Brandán YR,Favale NO,Sterin-Speziale NB,Márquez MG

更新日期：2019-08-01 00:00:00

abstract：:An artificial wound in a confluent monolayer of human keratinocyte HaCaT cells or mouse embryo fibroblast Swiss NIH 3T3 cells was used to analyze the effects of the nitric oxide (NO) chemical donor, S-nitroso-N-acetylpenicillamine (SNAP). SNAP exposure promoted an enhanced rate of wound closure and accelerated motilit...

journal_title：Journal of cellular physiology

authors： La Torre C,Cinque B,Lombardi F,Miconi G,Palumbo P,Evtoski Z,Placidi G,Fanini D,Cimini AM,Benedetti E,Giuliani M,Cifone MG

更新日期：2016-10-01 00:00:00

abstract：:To clarify the manner by which erythropoietin (EP), stem cell factor (SCF), or insulin-like growth factor I (IGF-I) regulate erythropoiesis, apoptosis of human erythroid progenitor cells was investigated. Human burst-forming units-erythroid (BFU-E) partially purified from peripheral blood were cultured for 6 days to g...

journal_title：Journal of cellular physiology

authors： Muta K,Krantz SB

更新日期：1993-08-01 00:00:00

abstract：:Acute lung injury, sepsis, lung inflammation, and ventilator-induced lung injury are life-threatening conditions associated with lung vascular barrier dysfunction, which may lead to pulmonary edema. Increased levels of atrial natriuretic peptide (ANP) in lung circulation reported in these pathologies suggest its poten...

journal_title：Journal of cellular physiology

authors： Birukova AA,Zagranichnaya T,Alekseeva E,Bokoch GM,Birukov KG

更新日期：2008-06-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder caused by the oncogenic activity of the Bcr-Abl protein, a deregulated tyrosine kinase. Calcium may act directly on cellular enzymes and in conjunction with other cellular metabolites, such as cyclic nucleotides, to regulate cell functions. Alteratio...

journal_title：Journal of cellular physiology

authors： Ciarcia R,d'Angelo D,Pacilio C,Pagnini D,Galdiero M,Fiorito F,Damiano S,Mattioli E,Lucchetti C,Florio S,Giordano A

更新日期：2010-08-01 00:00:00

abstract：:The single-copy gene of human basic fibroblast growth factor (bFGF) encodes four co-expressed isoforms, with an apparent molecular weight (M(r)) of 24 kD, 22.5 kD, 22 kD, and 18 kD, co-translated from a single mRNA. As a tool for the study of the role exerted by the different bFGF isoforms in the biology of endothelia...

journal_title：Journal of cellular physiology

authors： Gualandris A,Urbinati C,Rusnati M,Ziche M,Presta M

更新日期：1994-10-01 00:00:00