RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells.

abstract：:Fibronectin is a component of the extracellular matrix of developing microvessels whose role in angiogenesis is poorly understood. This study evaluated the effect of plasma fibronectin on angiogenesis in serum-free collagen gel culture of rat aorta. Aortic explants embedded in collagen gels generated microvascular out...

journal_title：Journal of cellular physiology

authors： Nicosia RF,Bonanno E,Smith M

更新日期：1993-03-01 00:00:00

abstract：:The in vitro culture of porcine bone marrow-derived mesenchymal stem cells (MSCs) was used for the investigation of adult stem cell biology. Isolated porcine MSCs possessed the ability to proliferate extensively in an antioxidants-rich medium containing 5% fetal bovine serum (FBS). Greater than 40 serial MSC passages ...

journal_title：Journal of cellular physiology

authors： Vacanti V,Kong E,Suzuki G,Sato K,Canty JM,Lee T

更新日期：2005-11-01 00:00:00

abstract：:Fluorescence anisotropy measurements are widely used as sensitive indicators of cell membrane fluidity. 1-[4-(trimethylamino)phenyl]-6-phenyl hexa-1,3,5-triene (TMA-DPH) is a cationic fluorescent aromatic hydrocarbon that anchors at the lipid-water interface of membrane lipid bilayers. Its uptake into porcine pulmonar...

journal_title：Journal of cellular physiology

authors： Sheridan NP,Block ER

更新日期：1988-01-01 00:00:00

abstract：:The C3H/10T 1/2 embryo cell line, which is nontumorigenic when inoculated subcutaneously in saline suspension, produces tumors when implanted subcutaneously attached to 1 X 5 X 10 mm plastic plates. Under these in vivo conditions there is direct selection for "spontaneous" transformants that have undergone the specifi...

journal_title：Journal of cellular physiology

authors： Paranjpe M,del Ande Eaton S,Boone CW

更新日期：1978-07-01 00:00:00

abstract：:Exposure of cultured endothelial cells to endotoxin causes an increase in the amount of cellular heparan sulfate proteoglycan and a depletion of this molecule in the extracellular matrix. Concomitant with the decrease in the extracellular matrix is the appearance of a fraction of proteoglycan bearing altered carbohydr...

journal_title：Journal of cellular physiology

authors： Colburn P,Kobayashi E,Buonassisi V

更新日期：1994-04-01 00:00:00

abstract：:Cells of rat parotid glands were maximally stimulated to initiate DNA synthesis by injecting into the animal a single dose of 25 to 150 mg of isoproterenol/kg of body weight. During the 18- to 21-hr prereplicative period following injection of the highest dose of the drug, there were two predominant and transient redi...

journal_title：Journal of cellular physiology

authors： Campos Gonzales R,Whitfield JF,Boynton AL,MacManus JP,Rixon RH

更新日期：1984-03-01 00:00:00

abstract：:A human osteosarcoma cell line, U-2 OS, cultured under serum-free conditions, was shown to produce a growth factor (osteosarcoma-derived growth factor, ODGF) for human-cultured glial cells, fibroblasts, and other cells. ODGF, collected from the spent medium of 2 OS cultures, was purified by a sequence involving hepari...

journal_title：Journal of cellular physiology

authors： Heldin CH,Westermark B,Wasteson A

更新日期：1980-11-01 00:00:00

abstract：:Tumor progression is characterized by loss of cell adhesion and increase of invasion and metastasis. The cell adhesion molecule E-cadherin is frequently down-regulated or mutated in tumors. In addition to down-regulation of cell adhesion, degradation of the extracellular matrix by matrix metalloproteinases is necessar...

journal_title：Journal of cellular physiology

authors： Fuchs M,Hermannstädter C,Specht K,Knyazev P,Ullrich A,Rosivatz E,Busch R,Hutzler P,Höfler H,Luber B

更新日期：2005-03-01 00:00:00

abstract：:ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snai...

journal_title：Journal of cellular physiology

authors： Zhu D,Zhou J,Zhao J,Jiang G,Zhang X,Zhang Y,Dong M

更新日期：2019-06-01 00:00:00

abstract：:Catecholamines produce mitotic inhibition in primary cell cultures of human keratinocytes probably via a block in the G2 part of the cell cycle. Epinephrine produced significant mitotic inhibition (49%) at a concentration as low as 4.5 X 10(-10) M, while its analog, isoproterenol, produced 47% inhibition at 1 X 10(-10...

journal_title：Journal of cellular physiology

authors： Harper RA,Flaxman BA

更新日期：1975-10-01 00:00:00

abstract：:Several papers report a hypoxia-induced upregulation of the endothelial nitric oxide synthase (eNOS) mRNA expression. Since there is no known hypoxia-sensitive element binding site in the eNOS promoter, we reasoned that the effect of hypoxia could be simulated by a metabolically elicited alteration of the redox state....

journal_title：Journal of cellular physiology

authors： Hoffmann A,Gloe T,Pohl U

更新日期：2001-07-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) stimulates expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control of stromal barrier proteolysis and cell-to-matrix adhesion. Pharmacologic agents that target MEK (PD98059, U0126) or src family (PP1) kinas...

journal_title：Journal of cellular physiology

authors： Samarakoon R,Higgins CE,Higgins SP,Kutz SM,Higgins PJ

更新日期：2005-07-01 00:00:00

abstract：:Bovine pulmonary artery endothelial cells in culture were used to assess the influence of oxygen tension on proteoglycan synthesis. Cells exposed to 3% O2 (hypoxia) for 72 h and then labeled with [35S]sulfate for 5 h accumulated significantly less [35S]proteoglycan in medium than cells exposed to 20% O2 (control). Thi...

journal_title：Journal of cellular physiology

authors： Humphries DE,Lee SL,Fanburg BL,Silbert JE

更新日期：1986-02-01 00:00:00

abstract：:Rat thyroid follicles in both the normal and the inverted configuration have been cultured in suspension. It has been found that normal follicles (i.e., those having a structural organization similar to the follicles in vivo) express most functional properties of the thyroid gland. They trap iodide, synthesize, secret...

journal_title：Journal of cellular physiology

authors： Tacchetti C,Zurzolo C,Monticelli A,Nitsch L

更新日期：1986-01-01 00:00:00

abstract：:Pathological calcification represents an event that consequently leads to a distinct elevation in the morbidity and mortality of patients with chronic kidney disease (CKD) in addition to strengthening its correlation with hyperphosphatemia. Epigenomic regulation by specific microRNAs (miRNAs) is reported to be involve...

journal_title：Journal of cellular physiology

authors： Xu TH,Qiu XB,Sheng ZT,Han YR,Wang J,Tian BY,Yao L

更新日期：2019-08-01 00:00:00

abstract：:Three-dimensional (3D) culture platforms have been explored to establish physiologically relevant cell culture environment and permit expansion scalability; however, little is known about the mechanisms underlying the regulation of pluripotency of human induced pluripotent stem cells (hiPSCs). This study elucidated ep...

journal_title：Journal of cellular physiology

authors： Thanuthanakhun N,Kino-Oka M,Borwornpinyo S,Ito Y,Kim MH

更新日期：2020-12-10 00:00:00

abstract：:Eukaryotic translation initiation factor 5A (eIF5A) has a unique character: the presence of an unusual amino acid, hypusine, which is formed by post-translational modifications. Even before the identification of hypusination in eIF5A, the correlation between hypusine formation and protein synthesis, shifting cell prol...

journal_title：Journal of cellular physiology

authors： Parreiras-e-Silva LT,Luchessi AD,Reis RI,Oliver C,Jamur MC,Ramos RG,Oliveira EB,Curi R,Costa-Neto CM

更新日期：2010-11-01 00:00:00

abstract：:Cardiac fibrosis is a pathological remodeling response to myocardial infarction (MI) and impairs cardiac contractility. Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is increased in patients with MI. However, the functions of MALAT1 in cardiac fibrosis have not been elucid...

journal_title：Journal of cellular physiology

authors： Huang S,Zhang L,Song J,Wang Z,Huang X,Guo Z,Chen F,Zhao X

更新日期：2019-03-01 00:00:00

abstract：:Peripheral nerve physiology and regeneration has been observed and investigated in literature but surgical applications to reconstruct and restore motor or sensory functions are still in a developmental phase. The peripheral nerve progresses slowly and incompletely compared with other tissues, it may provoke separatio...

journal_title：Journal of cellular physiology

authors： Riccio M,Marchesini A,Pugliese P,De Francesco F

更新日期：2019-04-01 00:00:00

abstract：:Induction of vascular smooth muscle (VSM) alpha-actin mRNA expression during cytodifferentiation of mouse BC3H1 myogenic cells coincides with the accumulation of cell surface- and extracellular matrix-associated sulfated proteoglycans. Inhibition of proteoglycan biosynthesis in myogenic cells using an artificial beta-...

journal_title：Journal of cellular physiology

authors： Lee SH,Yan H,Reeser JC,Dillman JM,Strauch AR

更新日期：1995-07-01 00:00:00

abstract：:Up-regulation of atrial natriuretic peptide (ANP) mRNA in the kidneys in several disorders has been demonstrated; however, evidence that ANP synthesized by the kidney exerts a local function has never been produced. Therefore, we investigated whether endogenous ANP could modulate high glucose-stimulated TGF-beta1, col...

journal_title：Journal of cellular physiology

authors： Lo CS,Chen CH,Hsieh TJ,Lin KD,Hsiao PJ,Shin SJ

更新日期：2009-06-01 00:00:00

abstract：:Mouse L-929 cells were subjected to increasing concentrations of sorbitol, which remove cell water and reduce volume osmotically. The rate of lactate production from glucose was significantly higher in osmotically perturbed cells than in controls, both in monolayers and in suspensions. L cells can apparently use sorbi...

journal_title：Journal of cellular physiology

authors： Clegg JS,Jackson SA,Fendl K

更新日期：1990-02-01 00:00:00

abstract：:Interleukin (IL)-8 is released both in visceral adipose tissue and in contracting skeletal muscles. In this study, we examined cellular pathways associated with muscle hypertrophy, chosen on the basis of microRNA profiling, in differentiating rat primary skeletal muscle cells (RSkMC) treated with IL-8 (1 ng/ml) for 11...

journal_title：Journal of cellular physiology

authors： Milewska M,Domoradzki T,Majewska A,Błaszczyk M,Gajewska M,Hulanicka M,Ciecierska A,Grzelkowska-Kowalczyk K

更新日期：2019-11-01 00:00:00

abstract：:MC3T3-E1 cells in culture exhibit a temporal sequence of development similar to in vivo bone formation. To examine whether the developmental expression of the osteoblast phenotype depends on serum derived factors, we compared the time-dependent expression of alkaline phosphatase (ALP)-a marker of osteoblastic maturati...

journal_title：Journal of cellular physiology

authors： Yohay DA,Zhang J,Thrailkill KM,Arthur JM,Quarles LD

更新日期：1994-03-01 00:00:00

abstract：:The significance of low pH-induced stimulation of osteoclastic bone resorption has recently been questioned following the finding that embryonic chick osteoclasts were only weakly stimulated by extremely low pH (6.5) and that the effect was transient, apparently due to cytotoxicity. Although low pH in the range 6.8-7....

journal_title：Journal of cellular physiology

authors： Murrills RJ,Stein LS,Dempster DW

更新日期：1993-03-01 00:00:00

abstract：:Insufficient invasion ability of trophoblasts might be associated with the development of recurrent miscarriage (RM). Ubiquitin-specific protease 25 (USP25) can regulate the processes of invasion and migration in different types of cancer cells. However, the effect of USP25 on trophoblasts and its roles in the develop...

journal_title：Journal of cellular physiology

authors： Ding J,Cheng Y,Zhang Y,Liao S,Yin T,Yang J

更新日期：2019-11-01 00:00:00

abstract：:The effect of retinoic acid on human fibroblasts was studied in a cell culture model of chronologic aging and photoaging. During early exponential phase, all trans-retinoic acid significantly stimulated growth rate of adult arm-derived dermal fibroblasts but not of newborn or adult foreskin-derived fibroblasts. Retino...

journal_title：Journal of cellular physiology

authors： Stanulis-Praeger BM,Gilchrest BA

更新日期：1989-04-01 00:00:00

abstract：:The tumor-promoting phorbol ester, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), stimulates starch-elicited mouse peritoneal macrophages to undergo DNA synthesis in vitro, apparently without the generation of an endogenous macrophage growth factor (MGF). No evidence was found for any synergistic interaction between TPA...

journal_title：Journal of cellular physiology

authors： Hamilton JA

更新日期：1983-04-01 00:00:00

abstract：:The beneficial effects of light-emitting diode (LED) irradiation have been reported in various pathologies, including cancer. However, its effect in pancreatic cancer cells remains unclear. Herein, we demonstrated that blue LED of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the e...

journal_title：Journal of cellular physiology

authors： Kim YM,Ko SH,Shin YI,Kim Y,Kim T,Jung J,Lee SY,Kim NG,Park KJ,Ryu JH

更新日期：2021-02-01 00:00:00

abstract：:It was the goal of this study to determine whether during long-term quiescence WI-38 cells gradually lose labile components which then need to be resynthesized before a stimulated cell can progress through G-1 and enter S. The metabolic and molecular status of WI-38 cells was systematically analyzed as they entered an...

journal_title：Journal of cellular physiology

authors： Owen TA,Carter R,Whitman MM,Soprano DR,Soprano KJ

更新日期：1990-01-01 00:00:00