Abstract:
:The beneficial effects of light-emitting diode (LED) irradiation have been reported in various pathologies, including cancer. However, its effect in pancreatic cancer cells remains unclear. Herein, we demonstrated that blue LED of 460 nm regulated pancreatic cancer cell proliferation and apoptosis by suppressing the expression of apoptosis-related factors, such as mutant p53 and B-cell lymphoma 2 (Bcl-2), and decreasing the expression of RAC-β serine/threonine kinase 2 (AKT2), the phosphorylation of protein kinase B (AKT), and mammalian target of rapamycin (mTOR). Blue LED irradiation also increased the levels of cleaved poly-(ADP-ribose) polymerase (PARP) and caspase-3 in pancreatic cancer cells, while it suppressed AKT2 expression and inhibited tumor growth in xenograft tumor tissues. In conclusion, blue LED irradiation suppressed pancreatic cancer cell and tumor growth by regulating AKT/mTOR signaling. Our findings indicated that blue LEDs could be used as a nonpharmacological treatment for pancreatic cancer.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Kim YM,Ko SH,Shin YI,Kim Y,Kim T,Jung J,Lee SY,Kim NG,Park KJ,Ryu JHdoi
10.1002/jcp.29943subject
Has Abstractpub_date
2021-02-01 00:00:00pages
1362-1374issue
2eissn
0021-9541issn
1097-4652journal_volume
236pub_type
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