MAPK pathway activation and the origins of pediatric low-grade astrocytomas.

Abstract:

:Low-grade astrocytomas (LGAs) are the most common type of brain tumor in children. Until recently, very little was known about the underlying biology and molecular genetics of these tumors. However, within the past year a number of studies have shown that the MAPK pathway is constitutively activated in a high proportion of LGAs. Several genetic aberrations which generate this deregulation of the MAPK pathway have been identified, most notably gene fusions between KIAA1549 and BRAF. In this review we summarize these findings, discuss how these gene fusions may arise and consider possible implications for diagnosis and treatment.

journal_name

J Cell Physiol

authors

Tatevossian RG,Lawson AR,Forshew T,Hindley GF,Ellison DW,Sheer D

doi

10.1002/jcp.21978

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

509-14

issue

3

eissn

0021-9541

issn

1097-4652

journal_volume

222

pub_type

杂志文章,评审
  • Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer.

    abstract::Many critical factors such as hypoxia, nutrient deficiency, activation of glycolytic pathway/Warburg effect contribute to the observed low pH in tumors compared to normal tissue. Studies suggest that such tumor specific acidic environment can be exploited for the development of therapeutic strategies against cancer. I...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.22865

    authors: Shamim U,Hanif S,Albanyan A,Beck FW,Bao B,Wang Z,Banerjee S,Sarkar FH,Mohammad RM,Hadi SM,Azmi AS

    更新日期:2012-04-01 00:00:00

  • Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells.

    abstract::The C-terminal region of parathyroid hormone-related protein (PTHrP) containing the sequence (107-111) appears to be a potent inhibitor of osteoclastic bone resorption. In the present study, we have investigated the effect of human (h)PTHrP (107-139) and hPTHrP (107-111)NH2 on the proliferation of osteoblastic rat ost...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199702)170:2<209::AID-JCP1

    authors: Valín A,García-Ocaña A,De Miguel F,Sarasa JL,Esbrit P

    更新日期:1997-02-01 00:00:00

  • Distinct characteristics of heregulin signals mediated by HER3 or HER4.

    abstract::Members of the epidermal growth-factor-receptor tyrosine-kinase (EGFR) family play important roles both in normal growth regulation/cell differentiation and in the genesis and progression of human neoplasia. In the present study, we analysed distinct heregulin (HRG) signals mediated by the HRG receptors HER3 and HER4....

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199711)173:2<187::AID-JCP1

    authors: Weiss FU,Wallasch C,Campiglio M,Issing W,Ullrich A

    更新日期:1997-11-01 00:00:00

  • Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation.

    abstract::Core binding factor β (Cbfβ) is a partner protein of Runx family transcription factors with minimally characterized function in cartilage. Here we address the role of Cbfβ in cartilage by generating chondrocyte-specific Cbfβ-deficient mice (Cbfb(Δch/Δch) ) from Cbfb-floxed mice crossed with mice expressing Cre from th...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25068

    authors: Park NR,Lim KE,Han MS,Che X,Park CY,Kim JE,Taniuchi I,Bae SC,Choi JY

    更新日期:2016-01-01 00:00:00

  • "APRIL hath put a spring of youth in everything": Relevance of APRIL for survival.

    abstract::A proliferation inducing ligand (APRIL or TALL-2 and TRDL-1) was first discovered as a cytokine over-expressed in many transformed cells and with the capacity to stimulate proliferation. APRIL was shown to bind two different receptors of the TNF receptor superfamily: B cell maturation antigen (BCMA) and transmembrane ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.21561

    authors: Kimberley FC,Hahne M,Medema JP

    更新日期:2009-01-01 00:00:00

  • The half-lives of platelet-derived growth factor A- and B-chain mRNAs are similar in endothelial cells and unaffected by heparin-binding growth factor-1 or cycloheximide.

    abstract::Platelet-derived growth factor (PDGF) is mitogenic and chemotactic for vascular smooth muscle cells cultured in vitro, and, thus, may play a role in the smooth muscle cell proliferation and migration that occurs during atherosclerotic lesion development. Two related PDGF polypeptides, designated as the A and B chains,...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041470116

    authors: Gay CG,Winkles JA

    更新日期:1991-04-01 00:00:00

  • Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1.

    abstract::Autocrine activation of the epidermal growth factor (EGF) receptor on keratinocytes has been recognized as an important growth regulatory mechanism involved in epithelial homeostasis, and, possibly, hyperproliferative diseases. Insulin-like growth factor (IGF)-1 and insulin have been shown to be paracrine keratinocyte...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041630206

    authors: Vardy DA,Kari C,Lazarus GS,Jensen PJ,Zilberstein A,Plowman GD,Rodeck U

    更新日期:1995-05-01 00:00:00

  • Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors.

    abstract::Bradykinin (BK) is a potent short-lived effector belonging to a class of peptides known as kinins. It participates in inflammatory and vascular regulation and processes including angioedema, tissue permeability, vascular dilation, and smooth muscle contraction. BK exerts its biological effects through the activation o...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.10175

    authors: Prado GN,Taylor L,Zhou X,Ricupero D,Mierke DF,Polgar P

    更新日期:2002-12-01 00:00:00

  • β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase.

    abstract::Erythropoietin (EPO), the key hormone for erythropoiesis, also increases nitric oxide (NO) bioavailability in endothelial cells (ECs), yet the definitive mechanisms are not fully understood. Increasing evidence has demonstrated that β common receptor (βCR) plays a crucial role in EPO-mediated non-hematopoietic effects...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.22678

    authors: Su KH,Shyue SK,Kou YR,Ching LC,Chiang AN,Yu YB,Chen CY,Pan CC,Lee TS

    更新日期:2011-12-01 00:00:00

  • Influence of nidogen complexed or not with laminin on attachment, spreading, and albumin and laminin B2 mRNA levels of rat hepatocytes.

    abstract::Nidogen/entactin is a Mr = 150,000 glycoprotein which is present within basement membranes in a noncovalent stable complex with laminin. We have studied the effects of nidogen/entactin complexed or not with laminin on attachment, spreading, and functions of adult rat hepatocytes in primary culture. Freshly isolated he...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041610210

    authors: Levavasseur F,Mayer U,Guillouzo A,Clement B

    更新日期:1994-11-01 00:00:00

  • Evidence suggesting a stimulatory role for interleukin-10 in erythropoiesis in vitro.

    abstract::Interleukin-10 (IL-10) has been shown to exert anti-inflammatory effects by suppressing macrophage proliferation and inhibiting cytokine production. In this study we show that in the presence of erythropoietin (EPO), the addition of IL-10 results in a significant dose-dependent increase in both Burst Forming Unit-Eryt...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4652(199602)166:2<305::AID-JCP8

    authors: Wang CQ,Udupa KB,Lipschitz DA

    更新日期:1996-02-01 00:00:00

  • Enhanced transbilayer mobility of phospholipids in malaria-infected monkey erythrocytes: a spin-label study.

    abstract::Using a recently described technique of electron spin resonance spectroscopy, we determined the rate of transbilayer mobility (flip) of the four major simian-erythrocyte phospholipids in the erythrocyte membrane after infection by Plasmodium knowlesi. The development of the malarial parasite induces a very large incre...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041350113

    authors: Beaumelle BD,Vial HJ,Bienvenüe A

    更新日期:1988-04-01 00:00:00

  • LPS Induces Hyper-Permeability of Intestinal Epithelial Cells.

    abstract::Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder leading to high morbidity and mortality rates. A growing body of evidence demonstrate the key role of the Toll like receptor 4 (TLR4) in NEC. This membranal receptor recognizes lipopolysaccharides (LPS) from the bacterial wall and triggers an inflammato...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25435

    authors: Bein A,Zilbershtein A,Golosovsky M,Davidov D,Schwartz B

    更新日期:2017-02-01 00:00:00

  • Regulation of cerebroside sulfotransferase activity in cultured oligodendrocytes: effect of growth factors and insulin.

    abstract::Cerebroside sulfotransferase (EC 2.8.2.11, CST) specific activity has been determined in oligodendrocyte (OL)-enriched glial cell cultures from newborn rat brain grown in serum supplemented medium. This activity is detectable at 5 days in vitro (DIV) and reaches its maximum value at 12 DIV. This period corresponds to ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041410327

    authors: Fressinaud C,Sarliève LL,Labourdette G

    更新日期:1989-12-01 00:00:00

  • Insulin-like growth factor binding protein (IGFBP)-5 is upregulated during both differentiation and apoptosis in primary cultures of mouse mammary epithelial cells.

    abstract::We have previously demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) is upregulated following treatment of the mouse mammary epithelial cell line HC11 with lactogenic hormones (dexamethasone, insulin, and prolactin-DIP). In addition, we have also shown that IGFBP-5 is upregulated in mammary epit...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.20587

    authors: Lochrie JD,Phillips K,Tonner E,Flint DJ,Allan GJ,Price NC,Beattie J

    更新日期:2006-05-01 00:00:00

  • Acyl-CoA synthetase short-chain family member 2 (ACSS2) is regulated by SREBP-1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells.

    abstract::Sterol regulatory element binding protein 1 (SREBP-1) is well-known as the master regulator of lipogenesis in rodents. Acyl-CoA synthetase short-chain family member 2 (ACSS2) plays a key role in lipogenesis by synthesizing acetyl-CoA from acetate for lipogenesis. ATP citrate lyase (ACLY) catalyzes the conversion of ci...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.25954

    authors: Xu H,Luo J,Ma G,Zhang X,Yao D,Li M,Loor JJ

    更新日期:2018-02-01 00:00:00

  • PERIOSTIN: role in formation and maintenance of dental tissues.

    abstract::The matricellular protein periostin is strongly expressed in collagen-rich connective tissues such as periodontal ligaments (PDLs), skeletal muscle, adipose tissue, tendons, skin, and bone. It is prominent in tumorigenesis, angiogenesis, and cardiac repair. It is localized in the periosteum and PDL, where it is seen i...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.24407

    authors: Romanos GE,Asnani KP,Hingorani D,Deshmukh VL

    更新日期:2014-01-01 00:00:00

  • Factors affecting the generation of mast cells from multipotential colony-forming cells.

    abstract::The cells responsible for the long-term in vitro generation of murine mast cells have been examined. Sequential analysis of all colony types obtained from cultures of spleen or bone marrow cells showed that only colonies derived from multipotential cells (mixed-erythroid colonies) or mast cell progenitors, contained c...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041210121

    authors: Li CL,Johnson GR

    更新日期:1984-10-01 00:00:00

  • Androgen receptor-related micro RNAs in prostate cancer and their role in antiandrogen drug resistance.

    abstract::Prostate cancer (PCa) is one of the most common cancers and the fifth most common reason for cancer deaths in the males. Surgical castration combined with androgen deprivation therapy, antiandrogens, and androgen synthesis inhibitors is the current therapeutic modalities for PCa. These strategies inhibit androgen synt...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章,评审

    doi:10.1002/jcp.29275

    authors: Rezaei S,Mahjoubin Tehran M,Sahebkar A,Jalili A,Aghaee-Bakhtiari SH

    更新日期:2020-04-01 00:00:00

  • Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells.

    abstract::Hedgehog (Hh) family members are involved in multiple cellular processes including proliferation, migration, differentiation, and cell fate determination. Recently, the novel Hh agonists Hh-Ag 1.3 and 1.7 were identified in a high-throughput screening of small molecule compounds that activate the expression of Gli1, a...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.24823

    authors: Nakamura T,Naruse M,Chiba Y,Komori T,Sasaki K,Iwamoto M,Fukumoto S

    更新日期:2015-04-01 00:00:00

  • Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation.

    abstract::Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory respo...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.27469

    authors: Fujihara C,Kanai Y,Masumoto R,Kitagaki J,Matsumoto M,Yamada S,Kajikawa T,Murakami S

    更新日期:2019-05-01 00:00:00

  • The alterations of circular RNA expression in plasma exosomes from patients with schizophrenia.

    abstract::Schizophrenia (SZ) is characterized by a high morbidity and disability rate and has gradually increased in rate and caused much burden. However, the pathogenesis of SZ is elusive and may include changes in the biological molecules in exosomes. In this study, we first compared the alterations of plasma exosomal circula...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.29873

    authors: Tan G,Wang L,Liu Y,Zhang H,Feng W,Liu Z

    更新日期:2021-01-01 00:00:00

  • Increasing content of poly A(+) mRNA of serum-stimulated cells in the absence of ribosome synthesis.

    abstract::When 3T6 cells undergo a serum-induced transition from resting to growing state, the number of ribosomes and the amounts of mRNA increase as the cells prepare for DNA synthesis. We have examined the effect of preventing ribosome synthesis during this transition. When resting cells are stimulated to grow in the presenc...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1040870202

    authors: Johnson LF,Penman S,Green H

    更新日期:1975-12-01 00:00:00

  • Evaluation of efficacy on RANKL induced osteoclast from RAW264.7 cells.

    abstract::Established RAW264.7 cell lines for osteoclastic differentiation has been widely engaged in bone homeostasis research, however, the efficacy of RANKL independently stimulating has rarely been defined, because protocols were usually developed and modified by various laboratories. Otherwise, problematic issues are also ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.27852

    authors: Song C,Yang X,Lei Y,Zhang Z,Smith W,Yan J,Kong L

    更新日期:2019-07-01 00:00:00

  • Identification of a prognostic alternative splicing signature in oral squamous cell carcinoma.

    abstract::Alternative splicing (AS) is critically associated with tumorigenesis and patient's prognosis. Here, we systematically analyzed survival-associated AS signatures in oral squamous cell carcinoma (OSCC) and evaluated their prognostic predictive values. Survival-related AS events were identified by univariate and multiva...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.29357

    authors: Zhang S,Wu X,Diao P,Wang C,Wang D,Li S,Wang Y,Cheng J

    更新日期:2020-05-01 00:00:00

  • Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA.

    abstract::The objective of this study was to establish whether human recombinant tumor necrosis factor (TNF) can significantly stimulate the proliferation of some tumor cells. Treatment with TNF had little or no effect on the growth of human tumor cells and murine NIH/3T3 cells cultured in medium with high serum concentration. ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041340321

    authors: Kirstein M,Baglioni C

    更新日期:1988-03-01 00:00:00

  • Effects of amphotericin B on ion transport proteins in airway epithelial cells.

    abstract::Topical intranasal application of the antifungal Amphotericin B (AmphoB) has been shown as an effective medical treatment of chronic rhinosinusitis. Because this antibiotic forms channels in lipid membranes, we considered the possibility that it affects the properties and/or cell surface expression of ion channels/pum...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.20347

    authors: Jornot L,Rochat T,Caruso A,Lacroix JS

    更新日期:2005-09-01 00:00:00

  • β2 adrenoceptor signaling regulates ion transport in 16HBE14o- human airway epithelial cells.

    abstract::We investigated the regulation of Cl- secretion by adrenoceptors in polarized 16HBE14o- human bronchial epithelial cells. Treatment with the nonselective β adrenoceptor agonist isoprenaline stimulated an increase in short-circuit current (ISC ), which was inhibited by the β adrenoceptor blocker propranolol. Treatment ...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.29683

    authors: Zhang RG,Yip CY,Pan KW,Cai MY,Ko WH

    更新日期:2020-11-01 00:00:00

  • Selective induction of enhanced complement receptor 3 activity on murine macrophages.

    abstract::A high proportion of murine resident peritoneal macrophages bear complement receptors 1 and 3 (CR1, CR3) which bind C3b and iC3b components of complement, respectively. By contrast, macrophages derived from bone marrow, blood, and the elicited peritoneal exudate are predominantly CR1+3. To determine if the microenviro...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.1041150110

    authors: Yen SE,Walker WS

    更新日期:1983-04-01 00:00:00

  • Upregulation of amphiregulin by retinoic acid and Wnt signalling promotes liver cancer cell proliferation.

    abstract::Activated hepatic stellate cells promote hepatocellular carcinoma (HCC) progression. Hepatic stellate cells play a key role in retinoid metabolism, and activation of stellate cells increases retinoic acid (RA) in the liver. However, the role of RA in HCC proliferation remains unclear. We aimed to analyse the mechanism...

    journal_title:Journal of cellular physiology

    pub_type: 杂志文章

    doi:10.1002/jcp.29088

    authors: Lin HH,Peng YJ,Tsai MJ,Wu YY,Tsai TN,Huang HH,Shih YL,Chang WK,Hsieh TY

    更新日期:2020-02-01 00:00:00