Abstract:
:We determined the mitogenic and comitogenic properties of tumor promoters in the indole alkaloid series; agents that differ structurally from 12-0-tetradecanoylphorbol-13-acetate (TPA), which is known to be a lymphocyte mitogen. Teleocidin and dihydroteleocidin B were mitogenic for human lymphocytes, and lyngbyatoxin A elicited little or no mitogenesis. Catalase enhanced the mitogenicity of teleocidin and dihydroteleocidin B, and lyngbyatoxin A was also mitogenic in the presence of catalase. The potency of the agents was TPA = teleocidin greater than dihydroteleocidin B greater than lyngbyatoxin A. Dimethylsulfoxide and butyric acid markedly inhibited proliferation induced by these agents in human lymphocytes. The indole alkaloid tumor promoters were all comitogenic for murine thymocytes and induced production of interleukin-2. While the comitogenic effect of teleocidin was similar to that of TPA in its susceptibility to inhibition by dimethylsulfoxide and butyric acid, the comitogenic effect of dihydroteleocidin B and lyngbyatoxin A were less susceptible to these agents. These findings may facilitate the identification of cellular sites responsible for the inhibitory effect of differentiating agents on proliferative responses of lymphocytes.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Novogrodsky A,Patya M,Fujiki H,Rubin AL,Stenzel KHdoi
10.1002/jcp.1041200106subject
Has Abstractpub_date
1984-07-01 00:00:00pages
36-40issue
1eissn
0021-9541issn
1097-4652journal_volume
120pub_type
杂志文章abstract::When calcium is removed from culture medium, motility of cultured cells is decreased. The effect is rapid, reversible and pronounced. Decreased motility is observed with normal mouse Balb/c 3T3 cells, mouse L929 cells, rat kidney fibroblasts and chick embryo fibroblasts. The calcium dependence of movement can be obser...
journal_title:Journal of cellular physiology
pub_type: 杂志文章
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journal_title:Journal of cellular physiology
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Journal of cellular physiology
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journal_title:Journal of cellular physiology
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更新日期:2012-10-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:1982-10-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of cellular physiology
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journal_title:Journal of cellular physiology
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doi:10.1002/jcp.21356
更新日期:2008-06-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2018-09-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:1990-12-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:1987-03-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:1986-06-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2021-02-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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更新日期:1999-10-01 00:00:00
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journal_title:Journal of cellular physiology
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of cellular physiology
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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更新日期:2020-10-01 00:00:00