α2A -AR antagonism by BRL-44408 maleate attenuates acute lung injury in rats with downregulation of ERK1/2, p38MAPK, and p65 pathway.

abstract：:In order to study the generation, factors controlling endogenous folate pools, and their functional importance, Friend erythroleukemia cells were grown in media containing 100; 1,000; and 10,000 ng/ml of tritiated pteroylglutamic acid (3H)PteGlu1 and then studied in unlabeled media with varying amounts of PteGlu1. The...

journal_title：Journal of cellular physiology

authors： Steinberg SE,Fonda S,Campbell CL,Hillman RS

更新日期：1983-02-01 00:00:00

abstract：:Construction of artificial organs and tissues by tissue engineering is strongly dependent on the availability of viable cells. For that reason, the viability and the physiological status of cells kept in culture must be evaluated before the cells can be used for clinical purposes. In this work, we determined the viabi...

journal_title：Journal of cellular physiology

authors： Alaminos M,Sanchez-Quevedo MC,Muñoz-Avila JI,García JM,Crespo PV,González-Andrades M,Campos A

更新日期：2007-06-01 00:00:00

abstract：:In certain epithelial tissues, activation of transient receptor potential (TRP) vanilloid subtype 1 (TRPV1) by noxious stimuli induces pro-inflammatory cytokine release, which helps to mitigate the challenge. While the corneal epithelium elicits such responses to a variety of challenges, it remains unknown whether TRP...

journal_title：Journal of cellular physiology

authors： Zhang F,Yang H,Wang Z,Mergler S,Liu H,Kawakita T,Tachado SD,Pan Z,Capó-Aponte JE,Pleyer U,Koziel H,Kao WW,Reinach PS

更新日期：2007-12-01 00:00:00

abstract：:The serum-free medium conditioned by the human colon cancer cell line HT-29 contains insulin-like growth factors (IGF) that are entirely complexed to binding proteins (IGF-BP). Gel filtration in acid conditions of the cell-conditioned medium permits separation of IGF-BP from two molecular forms of IGF of 15,000 and 7,...

journal_title：Journal of cellular physiology

authors： Culouscou JM,Remacle-Bonnet M,Garrouste F,Fantini J,Marvaldi J,Pommier G

更新日期：1990-06-01 00:00:00

abstract：:Aberrations of DNA methylation are early events in the development of tumors. In this study, we investigated the DNA methylation status of growth hormone secretagogue receptor (GHSR), a promising pan-cancer biomarker, in gastric cancer (GC). Initially, data sets from DNA methylation and gene expression studies availab...

journal_title：Journal of cellular physiology

authors： Amini M,Foroughi K,Talebi F,Aghagolzade Haji H,Kamali F,Jandaghi P,Hoheisel JD,Manoochehri M

更新日期：2019-01-24 00:00:00

abstract：:Syndecan-1 belongs to a family of transmembrane proteoglycans, acts as a coreceptor for growth factor binding, as well as cell-matrix and cell-cell interactions, and is induced in smooth muscle cells (SMCs) following balloon catheter injury. In this report, we investigated syndecan-1 expression in SMCs in response to ...

journal_title：Journal of cellular physiology

authors： Julien MA,Haller CA,Wang P,Wen J,Chaikof EL

更新日期：2007-04-01 00:00:00

abstract：:Cell therapy is one of the important therapeutic approaches in the treatment of many diseases such as cancer, degenerative diseases, and cardiovascular diseases. Among various cell types, which could be used as cell therapies, stem cell therapy has emerged as powerful tools in the treatment of several diseases. Multip...

journal_title：Journal of cellular physiology

authors： Baniebrahimi G,Khanmohammadi R,Mir F

更新日期：2019-03-01 00:00:00

abstract：:Smooth muscle responds to IP(3)-generating agonists by producing Ca(2+) waves. Here, the mechanism of wave progression has been investigated in voltage-clamped single smooth muscle cells using localized photolysis of caged IP(3) and the caged Ca(2+) buffer diazo-2. Waves, evoked by the IP(3)-generating agonist carbach...

journal_title：Journal of cellular physiology

authors： McCarron JG,Chalmers S,MacMillan D,Olson ML

更新日期：2010-08-01 00:00:00

abstract：:Asthma is the most common respiratory disease accompanied by lung inflammatory disorders. The main symptoms are airway obstruction, chronic inflammation due to mast cell and eosinophil activity, and the disturbance of immune responses mostly mediated by the Th2 response. Genetic background and environmental factors al...

journal_title：Journal of cellular physiology

authors： Mousavi SR,Ahmadi A,Jamalkandi SA,Salimian J

更新日期：2019-12-01 00:00:00

abstract：:3-Hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR) is the key and rate-limiting enzyme of cholesterol biosynthetic pathway. Although HMG-CoAR activity has already been related to the differentiation of some cellular lines there are no studies that analyze the role of HMG-CoAR, and the pathway it is involved wi...

journal_title：Journal of cellular physiology

authors： Martini C,Trapani L,Narciso L,Marino M,Trentalance A,Pallottini V

更新日期：2009-08-01 00:00:00

abstract：:The progression of cancer is often associated with genomic instability, which may develop as a result of compromised defense mechanisms responsible for the maintenance of chromosomal integrity. These include defects in telomere preservation, chromosomal segregation, and DNA repair. In this review, we discuss molecular...

journal_title：Journal of cellular physiology

authors： Reiss K,Khalili K,Giordano A,Trojanek J

更新日期：2006-02-01 00:00:00

abstract：:Current osteoinductive protein therapy utilizes bolus administration of large doses of bone morphogenetic proteins (BMPs), which is costly, and may not replicate normal bone healing. The limited in vivo biologic activity of BMPs requires the investigation of growth factors that may enhance this activity. In this study...

journal_title：Journal of cellular physiology

authors： Arosarena OA,Del Carpio-Cano FE,Dela Cadena RA,Rico MC,Nwodim E,Safadi FF

更新日期：2011-11-01 00:00:00

abstract：:A temperature-sensitive mutant with a defect in glycoprotein synthesis and a cell cycle (G1)-specific arrest at the nonpermissive temperature (Tenner et al., J. Cell. Physiol., 90:145-160, 1977; Tenner and Scheffler, J. Cell. Physiol., 98:251-266, 1979) was investigated further after a human epidermal growth factor (E...

journal_title：Journal of cellular physiology

authors： Feige JJ,Scheffler IE

更新日期：1987-12-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) hyperplasia plays a central role in chronic and acute vascular pathology including arteriosclerosis and restenosis following vascular surgery. The glycosaminoglycans of the heparan sulfate class, including heparin, inhibit VSMC proliferation in animals and in culture. Heparin binds t...

journal_title：Journal of cellular physiology

authors： Delmolino LM,Castellot JJ Jr

更新日期：1997-12-01 00:00:00

abstract：:Calcium-activated nucleotidase 1 (CANT1, belongs to the apyrase family, is widely expressed in various organs. However, the biological function of CANT1 remains poorly explored. In this study, we aimed to investigate the expression profile and functions of CANT1 in clear cell renal cell carcinoma (ccRCC). Our data sho...

journal_title：Journal of cellular physiology

authors： Liu X,Yang Z,Luo X,Luo J,Fu W,Fang Z,Xia D,Li L,Xu J

更新日期：2019-12-01 00:00:00

abstract：:Splenic erythroblasts obtained from mice during the acute disease caused by either the polycythemia-inducing (FVP) or anemia-inducing (FVA) strain of Friend virus were examined for their degree of terminal differentiation. Morphology, benzidine staining, and heme synthesis kinetics showed that many erythroblasts from ...

journal_title：Journal of cellular physiology

authors： Koury MJ,Sawyer ST,Bondurant MC

更新日期：1984-12-01 00:00:00

abstract：:BP3T3, a clonal benzo(a)pyrene-transformed BALB/c-3T3 cell line, is conditionally responsive to growth factor stimulation. Density arrested cell populations deprived of growth factors by pretreatment with 0.5% platelet-poor plasma synthesized DNA both in response to ng/ml concentrations of PDGF, EGF, and somatomedin C...

journal_title：Journal of cellular physiology

authors： Whipple AP,Furlanetto RW,Scher CD

更新日期：1987-02-01 00:00:00

abstract：:The v-src oncogene is one of only two oncogenes capable of transforming mouse embryo fibroblasts (MEFs) lacking the IGF-IR gene (R-cells). R-/v-src cells grow robustly in the absence of serum, suggesting the hypothesis that they may produce one or more growth factors that would sustain their ability to proliferate in ...

journal_title：Journal of cellular physiology

authors： Deangelis T,Quong A,Morrione A,Baserga R

更新日期：2013-07-01 00:00:00

abstract：:To clarify the manner by which erythropoietin (EP), stem cell factor (SCF), or insulin-like growth factor I (IGF-I) regulate erythropoiesis, apoptosis of human erythroid progenitor cells was investigated. Human burst-forming units-erythroid (BFU-E) partially purified from peripheral blood were cultured for 6 days to g...

journal_title：Journal of cellular physiology

authors： Muta K,Krantz SB

更新日期：1993-08-01 00:00:00

abstract：:When 3T6 cells undergo a serum-induced transition from resting to growing state, the number of ribosomes and the amounts of mRNA increase as the cells prepare for DNA synthesis. We have examined the effect of preventing ribosome synthesis during this transition. When resting cells are stimulated to grow in the presenc...

journal_title：Journal of cellular physiology

authors： Johnson LF,Penman S,Green H

更新日期：1975-12-01 00:00:00

abstract：:Adipogenesis plays a key role in the pathogenesis of obesity. It begins with the commitment of mesenchymal stem cells (MSCs) to the adipocyte lineage, followed by terminal differentiation of preadipocytes to mature adipocytes. A critical, but poorly understood, component of adipogenesis involves proliferation of MSCs ...

journal_title：Journal of cellular physiology

authors： Stewart A,Guan H,Yang K

更新日期：2010-06-01 00:00:00

abstract：:In recent years, research on glioma immunotherapy have grown rapidly. However, the autoimmune-like side effects that are caused by blocking immunological checkpoints hinder their clinical application in gliomas currently. Galectin-9, a ligand for T-cell immunoglobulin mucin 3, has shed a new light on the treatment of ...

journal_title：Journal of cellular physiology

authors： Yuan F,Ming H,Wang Y,Yang Y,Yi L,Li T,Ma H,Tong L,Zhang L,Liu P,Li J,Lin Y,Yu S,Ren B,Yang X

更新日期：2020-05-01 00:00:00

abstract：:We evaluated the role of cytoskeletal elements in the degradation of endogenous proteins via autophagy using biochemical and morphological techniques. In the absence of exogenous amino acids, degradation of endogenous proteins was enhanced in cultured normal rat kidney cells. This enhanced degradative state was accomp...

journal_title：Journal of cellular physiology

authors： Aplin A,Jasionowski T,Tuttle DL,Lenk SE,Dunn WA Jr

更新日期：1992-09-01 00:00:00

abstract：:The regulation of low-density lipoprotein (LDL) receptor activity in the human hepatoma cell line Hep-G2 by serum components was examined. Incubation of dense monolayers of Hep-G2 cells with fresh medium containing 10% fetal calf serum (FM) produced a time-dependent increase in LDL receptor activity. Uptake and degrad...

journal_title：Journal of cellular physiology

authors： Ellsworth JL,Brown C,Cooper AD

更新日期：1988-05-01 00:00:00

abstract：:Metabolic network modeling of microbial communities provides an in-depth understanding of community-wide metabolic and regulatory processes. Compared to single organism analyses, community metabolic network modeling is more complex because it needs to account for interspecies interactions. To date, most approaches foc...

journal_title：Journal of cellular physiology

authors： Henry CS,Bernstein HC,Weisenhorn P,Taylor RC,Lee JY,Zucker J,Song HS

更新日期：2016-11-01 00:00:00

abstract：:An increasing body of evidence shows that many of the key inositol lipids and enzymes responsible for their metabolism reside in nuclei. Moreover, the association of the nuclear phosphoinositide cycle with progression through the cell cycle and commitment toward differentiation has built a wider picture of the implica...

journal_title：Journal of cellular physiology

authors： Maraldi NM,Zini N,Santi S,Manzoli FA

更新日期：1999-11-01 00:00:00

abstract：:The mechanisms that regulate γ-tubulin, including its post-translational modifications, are poorly understood. γ-Tubulin is important for the duplication of centrioles and structurally similar basal bodies (BBs), organelles which contain a ring of nine triplet microtubules. The ciliate Tetrahymena thermophila carries ...

journal_title：Journal of cellular physiology

authors： Joachimiak E,Jerka-Dziadosz M,Krzemień-Ojak Ł,Wacławek E,Jedynak K,Urbanska P,Brutkowski W,Sas-Nowosielska H,Fabczak H,Gaertig J,Wloga D

更新日期：2018-11-01 00:00:00

abstract：:Cultures of HeLa cells, strains S3G (HeLa65) and S3K (HeLa71) were grown in plastic dishes until firmly attached and were then treated with sonic dispersions of Rosenthal's phospholipase inhibitor. A rapid increase in alkaline phosphatase activity occurred following this treatment in the S3G strain (low inducible alka...

journal_title：Journal of cellular physiology

authors： Melnykovych G,Lopez IC

更新日期：1977-07-01 00:00:00

abstract：:Fluorescence anisotropy measurements are widely used as sensitive indicators of cell membrane fluidity. 1-[4-(trimethylamino)phenyl]-6-phenyl hexa-1,3,5-triene (TMA-DPH) is a cationic fluorescent aromatic hydrocarbon that anchors at the lipid-water interface of membrane lipid bilayers. Its uptake into porcine pulmonar...

journal_title：Journal of cellular physiology

authors： Sheridan NP,Block ER

更新日期：1988-01-01 00:00:00

abstract：:The molecular and cellular mechanisms underlying vascular remodeling are currently investigated by experimental strategies which aim to mimic the complex environmental conditions found in vivo. Some of them focus on the tubulogenic activity of dispersed endothelial cell populations, while others evaluate vascular spro...

journal_title：Journal of cellular physiology

authors： Scianna M,Bassino E,Munaron L

更新日期：2017-02-01 00:00:00