Chemical and biological properties of a growth factor from human-cultured osteosarcoma cells: resemblance with platelet-derived growth factor.

abstract：:Diabetic nephropathy (DN) is an important factor leading to end-stage kidney disease that affects diabetes mellitus patients globally. Our previous transcriptome sequencing has identified a large group of differentially expressed long noncoding RNA (lncRNA) in early development of DN. On basis of this, we aimed to inv...

journal_title：Journal of cellular physiology

authors： Peng W,Huang S,Shen L,Tang Y,Li H,Shi Y

更新日期：2019-08-01 00:00:00

abstract：:Using a serum-free system, we have investigated the influence of human fibronectin (HFN) and selected growth factors (GF) on the attachment and growth of normal human keratinocytes in vitro. Single-cell suspensions of keratinocytes from near-confluent primary plates, plated on 5-10 microgram/cm2 HFN, showed approximat...

journal_title：Journal of cellular physiology

authors： Gilchrest BA,Calhoun JK,Maciag T

更新日期：1982-08-01 00:00:00

abstract：:Although it is well established that epidermal growth factor receptors (EGFRs) are asymmetrically expressed at the basolateral plasma membrane in polarized epithelial cells, how this process is regulated is not known. The purpose of this study was to address the mechanism of directed EGFR basolateral sorting using the...

journal_title：Journal of cellular physiology

authors： Hobert M,Carlin C

更新日期：1995-03-01 00:00:00

abstract：:Despite the improvements in fracture healing, about 10% of patients undergo abnormal healing. As a tumor suppressor, upregulation of microRNA (miR)-203 has been observed in osteogenic differentiation. Herein, we aimed to explore the functional role of miR-203 in osteoblasts as well as the underlying mechanisms. The ex...

journal_title：Journal of cellular physiology

authors： Liu H,Chen B,Li Y

更新日期：2019-08-01 00:00:00

abstract：:Nerve-evoked contractile activity in skeletal muscle regulates transcript and protein levels of many metabolic genes in a coordinate fashion, including the muscle isozyme of glycogen phosphorylase (MGP). Cellular signaling mechanisms mediating the activity-dependent modulation of MGP transcript levels were investigate...

journal_title：Journal of cellular physiology

authors： Vali S,Carlsen R,Pessah I,Gorin F

更新日期：2000-11-01 00:00:00

abstract：:Several studies have shown that interleukin-4 (IL-4) down-regulates synthesis of prostaglandin E2 (PGE2). We evaluated the mechanisms for this suppression in human alveolar macrophages (HAMs). Normal HAMs were obtained from healthy nonsmoking volunteers. The cells either remained unstimulated, or were exposed to 10 mi...

journal_title：Journal of cellular physiology

authors： Yano T,Hopkins HA,Hempel SL,Monick M,Hunninghake GW

更新日期：1995-10-01 00:00:00

abstract：:The serine protease thrombin has been proposed to be involved in neuromuscular plasticity. Its specific receptor "protease activated receptor-1" (PAR-1), a G protein-coupled receptor, has been shown to be expressed in myoblasts but not after fusion (Suidan et al., 1996 J Biol Chem 271:29162-29169). In the present work...

journal_title：Journal of cellular physiology

authors： Chevessier F,Hantaï D,Verdière-Sahuqué M

更新日期：2001-11-01 00:00:00

abstract：:Accumulating evidence demonstrates that PKCι is an oncogene and prognostic marker that is frequently targeted for genetic alteration in many major forms of human cancer. Functional data demonstrate that PKCι is required for the transformed phenotype of lung, pancreatic, ovarian, prostate, colon, and brain cancer cells...

journal_title：Journal of cellular physiology

authors： Murray NR,Kalari KR,Fields AP

更新日期：2011-04-01 00:00:00

abstract：:Activation of the epidermal growth factor receptor (EGFR) has been shown to occur by ligand-dependent and ligand-independent mechanisms. Different molecular mechanisms have been found to be responsible for ligand-independent receptor transactivation. Here, we show that hyperosmolar concentrations of sorbitol activate ...

journal_title：Journal of cellular physiology

authors： Cheng H,Kartenbeck J,Kabsch K,Mao X,Marqués M,Alonso A

更新日期：2002-08-01 00:00:00

abstract：:We performed a network meta-analysis (NMA) to compare the short- and long-term efficacy of Gemcitabine, Gemcitabine + S-1 (tegafur), Gemcitabine + nab-paclitaxel, Gemcitabine + Capecitabine, Gemcitabine + Cisplatin, FOLFIRINOX (oxaliplatin + irinotecan + fluorouracil + leucovorin), Gemcitabine + oxaliplatin, Gemcitabi...

journal_title：Journal of cellular physiology

authors： Zhang SH,Liu GF,Li XF,Liu L,Yu SN

更新日期：2018-04-01 00:00:00

abstract：:A new system for studying growth of normal human mammary epithelial cells in an in vivo environment using athymic nude mice is described. Human mammary epithelial cells dissociated from reduction mammoplasty specimens were embedded within collagen gels and subsequently transplanted subcutaneously into nude mice. Histo...

journal_title：Journal of cellular physiology

authors： Popnikolov NK,Yang J,Guzman RC,Swanson SM,Thordarson G,Collins G,Talamantes F,Nandi S

更新日期：1995-04-01 00:00:00

abstract：:The effects of artificial cryptorchidism and its surgical reversal on spermatogenesis were examined in germ cell mutant, S1/+ and wild type, +/+, mice. In cryptorchid testes no difference was found between S1/+ and +/+ mice in the number of undifferentiated type A spermatogonia. The activity of type A spermatogonia in...

journal_title：Journal of cellular physiology

authors： Nishimune Y,Haneji T,Kitamura Y

更新日期：1980-10-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:Despite a high degree of structural homology and shared exchange factors, effectors and GTPase activating proteins, a large body of evidence suggests functional heterogeneity among Ras isoforms. One aspect of Ras biology that may explain this heterogeneity is the differential subcellular localizations driven by the C-...

journal_title：Journal of cellular physiology

authors： Lynch SJ,Snitkin H,Gumper I,Philips MR,Sabatini D,Pellicer A

更新日期：2015-03-01 00:00:00

abstract：:Detailed information regarding the synthesis rates of individual protein components is important in understanding the assembly and dynamics of the cytoskeletal matrix of eukaryotic cells. As an approach to this topic, the dual isotope technique of Clark and Zak (J. Biol. Chem., 256:4863-4870, 1981), was employed to me...

journal_title：Journal of cellular physiology

authors： Mitchell JJ,Low RB,Woodcock-Mitchell JL

更新日期：1990-06-01 00:00:00

abstract：:Endothelin (ET)-1 was originally characterized as a potent vasoconstrictor peptide secreted by vascular endothelial cells. It possesses a wide range of biological activities within the cardiovascular system and in other organs, including the brain. Also secreted by endothelial cells, nitric oxide (NO), has recently be...

journal_title：Journal of cellular physiology

authors： Durieu-Trautmann O,Fédérici C,Créminon C,Foignant-Chaverot N,Roux F,Claire M,Strosberg AD,Couraud PO

更新日期：1993-04-01 00:00:00

abstract：:Evidence is emerging that long noncoding RNAs (lncRNAs) play vital roles in tumorigenesis. LncRNA gastric cancer-associated transcript 3 (GACAT3) is reported to participate in the development of breast cancer, colorectal cancer, nonsmall cell lung cancer, and gastric cancer. However, whether it is implicated in glioma...

journal_title：Journal of cellular physiology

authors： Pan B,Zhao M,Xu L

更新日期：2019-06-01 00:00:00

abstract：:Cultured bovine aortic endothelial cells were fixed and stained with NBD-phallicidin and quantitated with a digital image analyzer for changes in actin cables and surface area. Serotonin (5-HT), norepinephrine (NE), dopamine and histamine (all at 10(-4)M concentrations) were tested for their ability to induce cytoskel...

journal_title：Journal of cellular physiology

authors： Welles SL,Shepro D,Hechtman HB

更新日期：1985-06-01 00:00:00

abstract：:To determine if Chinese Hamster Ovary (CHO) cells in culture are able to metabolize steroids, CHO cells were incubated in defined medium with [14C]pregnenolone. As shown, [14C]pregnenolone is metabolized to progesterone and other delta 53 beta steroids; this steroidogenic response is appreciably enhanced upon exposure...

journal_title：Journal of cellular physiology

authors： Evain D,Anderson WB,Saez MJ

更新日期：1981-07-01 00:00:00

abstract：:Long suspected, recently recognized, and increasingly studied, non protein-coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking findings, establis...

journal_title：Journal of cellular physiology

authors： Tye CE,Gordon JA,Martin-Buley LA,Stein JL,Lian JB,Stein GS

更新日期：2015-03-01 00:00:00

abstract：:Cultivation of human parotid glands in serum-free medium (Ca(2+) concentration, 0.2 mM) with growth supplements resulted in isolation of a homogeneous population of epithelial cells without any mesenchymal cells. The isolated cells showed an undifferentiated phenotype with scant cytoplasmic organelles, and low levels ...

journal_title：Journal of cellular physiology

authors： Hiraki A,Shirasuna K,Ikari T,Shinohara M,Garrod DR

更新日期：2002-10-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS), characterized by acute hypoxic respiratory dysfunction or failure, is a manifestation of multiple organ failure in the lung, and the most common risk factor is sepsis. We previously showed that blocking α2 -adrenoceptor (α2 -AR) could attenuate lung injury induced by endotox...

journal_title：Journal of cellular physiology

authors： Cong Z,Li D,Tao Y,Lv X,Zhu X

更新日期：2020-10-01 00:00:00

abstract：:Wnt5a, a member of the noncanonical Wnt proteins, is known to play important roles in the development of various organs and in postnatal cell functions. However, little is known about the effects of Wnt5a on human periodontal ligament (PDL) cells. In this study, we examined the localization and potential function of W...

journal_title：Journal of cellular physiology

authors： Hasegawa D,Wada N,Maeda H,Yoshida S,Mitarai H,Tomokiyo A,Monnouchi S,Hamano S,Yuda A,Akamine A

更新日期：2015-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) function as signaling molecules mainly by reversible oxidation of redox-sensitive target proteins. ROS can be produced in response to integrin ligation and growth factor stimulation through Rac1 and its effector protein NADPH oxidase. One of the central roles of Rac1-NADPH oxidase is acti...

journal_title：Journal of cellular physiology

authors： Flinder LI,Timofeeva OA,Rosseland CM,Wierød L,Huitfeldt HS,Skarpen E

更新日期：2011-09-01 00:00:00

abstract：:Phosphoribosylpyrophosphate synthetase activity was determined in Friend virus-inducted erythroleukemic cells in culture, stimulated to differentiate in the presence of dimethylsulfoxide. The activity of phosphoribosylpyrophosphate synthetase did not decrease in cells which had acquired the specialized function of hem...

journal_title：Journal of cellular physiology

authors： Reem GH,Friend C

更新日期：1976-06-01 00:00:00

abstract：:We have previously shown that retinoic acid (RA) has protective effects on high glucose (HG)-induced cardiomyocyte apoptosis. To further elucidate the molecular mechanisms of RA effects, we determined the interaction between nuclear factor (NF)-κB and RA signaling. HG induced a sustained phosphorylation of IKK/IκBα an...

journal_title：Journal of cellular physiology

authors： Nizamutdinova IT,Guleria RS,Singh AB,Kendall JA Jr,Baker KM,Pan J

更新日期：2013-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is prevalent chronic liver diseases with unknown mechanism and no curative treatment. Hepatokines have demonstrated importance in NAFLD but, role of selenoprotein P (SeP) in NAFLD is unknown. A total of 79 patients with NAFLD and 79 healthy controls were included in this case-c...

journal_title：Journal of cellular physiology

authors： Chen Y,He X,Chen X,Li Y,Ke Y

更新日期：2020-10-22 00:00:00

abstract：:DNA methylation can regulate gene expression and is pivotal in the occurrence and development of bladder cancer. In this study, we analyzed whole-genome DNA methylation on the basis of data from The Cancer Genome Atlas to select epigenetic biomarkers predictive of survival and further understand the molecular mechanis...

journal_title：Journal of cellular physiology

authors： Yang Z,Liu A,Xiong Q,Xue Y,Liu F,Zeng S,Zhang Z,Li Y,Sun Y,Xu C

更新日期：2019-08-01 00:00:00

abstract：:The mechanisms of agonist-induced calcium entry (ACE) following depletion of intracellular calcium stores have not been fully established. We report here that calcium-independent phospholipase A (iPLA(2)) is required for robust Ca(2+) entry in HaCaT keratinocytes following ATP or UTP stimulation. Lysophosphatidic acid...

journal_title：Journal of cellular physiology

authors： Ross K,Whitaker M,Reynolds NJ

更新日期：2007-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that are ubiquitous from animals to plants and have pivotal functions in nearly all biological and metabolic processes. Increasing evidence shows that miRNAs are also new players regulating many protein-coding genes and spec...

journal_title：Journal of cellular physiology

authors： Chen D,Farwell MA,Zhang B

更新日期：2010-11-01 00:00:00