Abstract：
:Resistance to conventional chemotherapy remains a major cause of cancer relapse and cancer-related deaths. Therefore, there is an urgent need to overcome resistance barriers. To improve cancer treatment approaches, it is critical to elucidate the basic mechanisms underlying drug resistance. Increasingly, the mechanisms involving micro-RNAs (miRNAs) are studied because miRNAs are also considered practical therapeutic options due to high degrees of specificity, efficacy, and accuracy, as well as their ability to target multiple genes at the same time. Years of research have firmly established miR-34 as a key tumor suppressor miRNA whose target genes are involved in drug resistance mechanisms. Indeed, numerous articles show that low levels of circulating miR-34 or tumor-specific miR-34 expression are associated with poor response to chemotherapy. In addition, elevation of inherently low miR-34 levels in resistant cancer cells effectively restores sensitivity to chemotherapeutic agents. Here, we review this literature, also highlighting some contradictory observations. In addition, we discuss the potential utility of miR-34 expression as a predictive biomarker for chemotherapeutic drug response. Although caution needs to be exercised, miR-34 is emerging as a biomarker that could improve cancer precision medicine.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Naghizadeh S,Mohammadi A,Duijf PHG,Baradaran B,Safarzadeh E,Cho WC,Mansoori Bdoi
10.1002/jcp.29640subject
Has Abstractpub_date
2020-10-01 00:00:00pages
6424-6440issue
10eissn
0021-9541issn
1097-4652journal_volume
235pub_type
杂志文章,评审abstract：:The significance of low pH-induced stimulation of osteoclastic bone resorption has recently been questioned following the finding that embryonic chick osteoclasts were only weakly stimulated by extremely low pH (6.5) and that the effect was transient, apparently due to cytotoxicity. Although low pH in the range 6.8-7....
journal_title：Journal of cellular physiology
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journal_title：Journal of cellular physiology
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journal_title：Journal of cellular physiology
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更新日期：2019-08-01 00:00:00
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更新日期：2020-12-28 00:00:00
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journal_title：Journal of cellular physiology
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更新日期：1998-06-01 00:00:00
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journal_title：Journal of cellular physiology
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更新日期：1986-08-01 00:00:00
