Dysregulated calcium homeostasis and oxidative stress in chronic myeloid leukemia (CML) cells.

abstract：:Bioactive lipid mediators derived from n-3 and n-6 fatty acids are known to modulate leukocytes. Metabolic transformation of essential fatty acids to endogenous bioactive molecules plays a major role in human health. Here we tested the potential of substrates; linoleic acid (LA) and docosahexaenoic acid (DHA) and thei...

journal_title：Journal of cellular physiology

authors： Kain V,Halade GV

更新日期：2019-04-01 00:00:00

abstract：:Rous sarcoma virus (RSV)-infected chicken embryo cells were used to study the effect of viral transformation on the hormone-stimulated synthesis of cyclic AMP. Transformation by RSV greatly increased the cells' ability to synthesize and accumulate cyclic AMP in response to the beta-adrenergic agonist isoproterenol as ...

journal_title：Journal of cellular physiology

authors： Howard RF,Friis RR,Sheppard JR,Glossmann H

更新日期：1982-06-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:Confluent cultures of adult bovine aortic endothelial (ABAE), corneal endothelial (BCE), and fetal bovine heart endothelial (FBHE) cells form a monolayer of highly flattened, closely apposed, and nonoverlapping cells. In ABAE and BCE cultures, this is associated with a 50-fold decrease in the rate of DNA sythesis and ...

journal_title：Journal of cellular physiology

authors： Savion N,Vlodavsky I,Greenburg G,Gospodarowicz D

更新日期：1982-02-01 00:00:00

abstract：:Terminal deoxynucleotidyl transferase (TdT) is a template-independent DNA polymerase that is transiently expressed during the normal development of T and B lymphocytes. Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines. We ...

journal_title：Journal of cellular physiology

authors： Beland JL,Yuille MA,Hugunin M,Zhang XM,Silverstone AE

更新日期：1990-03-01 00:00:00

abstract：:Exposure of neutrophils to a variety of agonists including soluble chemoattractant peptides and cytokines results in degranulation and activation of the oxidative burst (effector functions) that are required for bacterial killing. At present, the signaling pathways regulating these important functions are incompletely...

journal_title：Journal of cellular physiology

authors： Sue-A-Quan AK,Fialkow L,Vlahos CJ,Schelm JA,Grinstein S,Butler J,Downey GP

更新日期：1997-07-01 00:00:00

abstract：:We have reported previously that the production of a tumor cell factor that stimulates synthesis of fibroblast collagenase is influenced by a fibroblast-deposited matrix component, possibly heparan sulfate-proteoglycan. In this study, binding sites for heparin and heparan sulfate on mouse B-16 melanoma cells have been...

journal_title：Journal of cellular physiology

authors： Biswas C

更新日期：1988-07-01 00:00:00

abstract：:Human cell lines derived from a melanoma and a colon carcinoma, and cultures of human melanocytes and intestinal epithelial cells, as well as a mouse mesenchymal non-neoplastic cell line and a malignant subline of the same have been quantitatively studied in tissue culture for their sensitivity to thymidine. All three...

journal_title：Journal of cellular physiology

authors： Lee SS,Giovanella BC,Stehlin JS Jr

更新日期：1977-09-01 00:00:00

abstract：:The synthesis and turnover of metabolically labeled proteoglycans from medium, cell layer, and substratum-associated compartments were characterized in four cell lines of fibroblastic origin, including a fibrosarcoma line, and in the murine melanoma cell type, B16.F10. Substantial differences were apparent between the...

journal_title：Journal of cellular physiology

authors： Piepkorn M,Hovingh P,Linker A

更新日期：1988-05-01 00:00:00

abstract：:We can distinguish two classes of membrane transport changes in cultured cells: (a) growth-rate contingent changes are those which occur in coordination with the onset of density-dependent inhibition of growth; (b) transformation-specific changes are those which occur when cells become transformed, and which can be de...

journal_title：Journal of cellular physiology

authors： Weber MJ,Hale AH,Yau TM,Buckman T,Johnson M,Brady TM,LaRossa DD

更新日期：1976-12-01 00:00:00

abstract：:Protease nexin-I (PN-I, Mr approximately 43,000) is representative of a newly described class of cell-secreted protease inhibitors. PN-I has been purified to apparent homogeneity, partially sequenced, and monospecific antibodies have been raised against it. PN-I is a potent inhibitor of urokinase, thrombin, plasmin, a...

journal_title：Journal of cellular physiology

authors： Knauer DJ,Orlando RA,Rosenblatt D

更新日期：1987-08-01 00:00:00

abstract：:Muc4 (also called Sialomucin complex) is a heterodimeric glycoprotein complex consisting of a peripheral O-glycosylated subunit ASGP-1 (ascites sialoglycoprotein-1) tightly but non-covalently bound to an N-glycosylated transmembrane subunit ASGP-2. Muc4/SMC can act as an intramembrane ligand for ErbB2 via an EGF-like ...

journal_title：Journal of cellular physiology

authors： Price-Schiavi SA,Andrechek E,Idris N,Li P,Rong M,Zhang J,Carothers Carraway CA,Muller WJ,Carraway KL

更新日期：2005-04-01 00:00:00

abstract：:Prostate cancer (PCa) is the second leading cause of death among American men. Increasing evidence has shown that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis of PCa. In this study, we explored the biological functions of small nucleolar RNA host gene 12 (SNHG12) and investigated the interaction...

journal_title：Journal of cellular physiology

authors： Cheng G,Song Z,Liu Y,Xiao H,Ruan H,Cao Q,Wang K,Xiao W,Xiong Z,Liu D,Chen K,Zhang X

更新日期：2020-02-01 00:00:00

abstract：:Synovial fibroblasts (SFs) of rheumatoid arthritis (RA) are phenotypically aggressive, typically progressing into arthritic cartilage degradation. Throughout our study, we made explorations into the effects of microRNA-135a (miR-135a) on the SFs involved in RA by mediating the phosphatidylinositol 3-kinase (PI3K)/AKT ...

journal_title：Journal of cellular physiology

authors： Qu Y,Zhang YP,Wu J,Jie LG,Deng JX,Zhao DB,Yu QH

更新日期：2019-08-01 00:00:00

abstract：:Circular RNAs (circRNAs) are stable and abundantly expressed in vivo but are abnormally expressed in several diseases. This study aimed to identify circRNAs acting as potential biomarkers for cardiovascular disease (CVD). Research were retrieved from the articles published by September 2018 in eight databases to compa...

journal_title：Journal of cellular physiology

authors： Li JJ,Wang W,Wang XQ,He Y,Wang SS,Yan YX

更新日期：2019-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD), as a chronic and recurrent inflammatory disorder, is caused by a dysregulated and aberrant immune response to exposed environmental factors in genetically susceptible individuals. Despite huge efforts in determining the molecular pathogenesis of IBD, an increasing worldwide incidence ...

journal_title：Journal of cellular physiology

authors： Moein S,Vaghari-Tabari M,Qujeq D,Majidinia M,Nabavi SM,Yousefi B

更新日期：2019-04-01 00:00:00

abstract：:Detailed information regarding the synthesis rates of individual protein components is important in understanding the assembly and dynamics of the cytoskeletal matrix of eukaryotic cells. As an approach to this topic, the dual isotope technique of Clark and Zak (J. Biol. Chem., 256:4863-4870, 1981), was employed to me...

journal_title：Journal of cellular physiology

authors： Mitchell JJ,Low RB,Woodcock-Mitchell JL

更新日期：1990-06-01 00:00:00

abstract：:The glucose analogues, 3-O-methyl-D-glucose and 2-deoxy-D-glucose, have been used to characterize glucose transport and its regulation by serum and growth factors in monolayer cultures of granulosa cells obtained from bovine ovaries. Uptake of 3-O-methylglucose was shown to be independent of the Na+-gradient, independ...

journal_title：Journal of cellular physiology

authors： Allen WR,Nilsen-Hamilton M,Hamilton RT

更新日期：1981-07-01 00:00:00

abstract：:Neuronal activity-dependent gene transcription is a key feature of long-lasting synaptic strengthening associated with learning and memory, as well as activity-dependent neuroprotection. To comprehensively determine the molecular alterations, we carried out genome-wide microarray analysis in cultured rat cortical neur...

journal_title：Journal of cellular physiology

authors： Xiang G,Pan L,Xing W,Zhang L,Huang L,Yu J,Zhang R,Wu J,Cheng J,Zhou Y

更新日期：2007-07-01 00:00:00

abstract：:Prostate cancer (PCa) is one of the most common cancers and the fifth most common reason for cancer deaths in the males. Surgical castration combined with androgen deprivation therapy, antiandrogens, and androgen synthesis inhibitors is the current therapeutic modalities for PCa. These strategies inhibit androgen synt...

journal_title：Journal of cellular physiology

authors： Rezaei S,Mahjoubin Tehran M,Sahebkar A,Jalili A,Aghaee-Bakhtiari SH

更新日期：2020-04-01 00:00:00

abstract：:Cell fusion occurs during fertilization and in the formation of organs such as muscles, placenta, and bones. We have developed an experimental model for epithelial cell fusion which permits analysis of the processes during junction disintegration and formation of polykaryons (Palovuori and Eskelinen [2000] Eur. J. Cel...

journal_title：Journal of cellular physiology

authors： Palovuori R,Myrsky E,Eskelinen S

更新日期：2004-09-01 00:00:00

abstract：:To evaluate the regulation of endothelial cell Cu,Zn-SOD, we have exposed bovine pulmonary artery endothelial cells in culture to hyperoxia and hypoxia, second messengers or related agonists, hormones, free radical generating systems, endotoxin, and cytokines and have measured Cu,Zn-SOD protein of these cells by an EL...

journal_title：Journal of cellular physiology

authors： Kong XJ,Fanburg BL

更新日期：1992-12-01 00:00:00

abstract：:CCN1 is highly expressed in cancer cells and has been identified in the secretome of bone marrow-derived mesenchymal stem cells (BM-MSC). Although secreted CCN1 is known to promote angiogenesis, its underlying mechanism remains unclear. Here, we examined whether our recently-established tonsil-derived MSC (T-MSC) secr...

journal_title：Journal of cellular physiology

authors： Park YS,Hwang S,Jin YM,Yu Y,Jung SA,Jung SC,Ryu KH,Kim HS,Jo I

更新日期：2015-01-01 00:00:00

abstract：:Proliferative vitroretinopathy (PVR) is caused by retinal pigment epithelial (RPE) cell proliferation and transformation into fibrotic cells that produce extracellular matrix (ECM) components. Transforming growth factor beta1 (TGF-beta1) is known to play an important role in PVR pathogenesis. To determine how TGF-beta...

journal_title：Journal of cellular physiology

authors： Lee J,Ko M,Joo CK

更新日期：2008-08-01 00:00:00

abstract：:Considerable evidence has accumulated for a role of a nonsteroidal mevalonate product in the regulation of DNA replication and cell division. We report here a similar requirement for mevalonate in a nonreplicative function, that of natural killer (NK) cell cytotoxicity. Treatment of NK cells with 10 microM compactin f...

journal_title：Journal of cellular physiology

authors： Cutts JL,Scallen TJ,Watson J,Bankhurst AD

更新日期：1989-06-01 00:00:00

abstract：:The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mu...

journal_title：Journal of cellular physiology

authors： Johnson EM,Daniel DC,Gordon J

更新日期：2013-05-01 00:00:00

abstract：:Adhesion of human monocytes and granulocytes to vascular endothelium plays an important role in migration of these cells to inflammatory sites in tissues. A family of three human leukocyte heterodimeric surface molecules named Mo1, LFA-1, and p150,95 (LeuM5) has been shown to mediate leukocyte adhesion to confluent mo...

journal_title：Journal of cellular physiology

authors： Arnaout MA,Lanier LL,Faller DV

更新日期：1988-11-01 00:00:00

abstract：:Three-dimensional (3D) culture platforms have been explored to establish physiologically relevant cell culture environment and permit expansion scalability; however, little is known about the mechanisms underlying the regulation of pluripotency of human induced pluripotent stem cells (hiPSCs). This study elucidated ep...

journal_title：Journal of cellular physiology

authors： Thanuthanakhun N,Kino-Oka M,Borwornpinyo S,Ito Y,Kim MH

更新日期：2020-12-10 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) and the vitamin D receptor (VDR) have been reported to have an important role in the regulation of innate immunity. We earlier reported that the antimicrobial peptide cathelicidin is induced by 1,25(OH)2D3 in normal human bronchial epithelial cells with a resultant increase in an...

journal_title：Journal of cellular physiology

authors： Dhawan P,Wei R,Sun C,Gombart AF,Koeffler HP,Diamond G,Christakos S

更新日期：2015-02-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer death worldwide. As a platinum-based chemotherapeutic drug, cisplatin has been used for over 30 years in NSCLC treatment while its effects are diminished by drug resistance. Therefore, we aimed to study the potential role of UCA1 in the development...

journal_title：Journal of cellular physiology

authors： Li C,Fan K,Qu Y,Zhai W,Huang A,Sun X,Xing S

更新日期：2020-04-01 00:00:00