Small GTPase Arf6 regulates diabetes-induced cholesterol accumulation in podocytes.

abstract：:Cytoskeleton not only controls cell morphology but also regulates cell growth, migration, differentiation, and gene expression, events which are fundamental to embryogenesis, carcinogenesis, and wound healing. We have recently reported that reorganization of cytoskeleton induces expression of mRNA for transforming gro...

journal_title：Journal of cellular physiology

authors： Varedi M,Ghahary A,Scott PG,Tredget EE

更新日期：1997-08-01 00:00:00

abstract：:Fibroblastic and epithelioid clones have been isolated from the normal rat kidney line, NRK. These clones were studied for their ability to bind epidermal growth factor (EGF), susceptibility to transformation by mouse sarcoma virus (MSV), and alteration in EGF binding upon sarcoma virus transformation. The epithelioid...

journal_title：Journal of cellular physiology

authors： de Larco JE,Todaro GJ

更新日期：1978-03-01 00:00:00

abstract：:Liver regeneration involves not only hepatocyte replication but progenitor aggregation and scarring. Partial hepatectomy (PH), an established model for liver regeneration, reactivates transforming growth factor-β (TGF-β) signaling. Hepatic stellate cells (HSCs) are primarily responding cells for TGF-β and resident in ...

journal_title：Journal of cellular physiology

authors： Chen Z,Wan L,Jin X,Wang W,Li D

更新日期：2020-03-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are clonogenic, self-renewing, and multi-potential DPSCs capable of differentiating into osteoblasts. In this study, primary cell cultures were obtained from human dental pulp tissue of developing third molars, and flow cytometry was used to sort the subpopulation of DPSCs with STRO-1 an...

journal_title：Journal of cellular physiology

authors： Huang CH,Tseng WY,Yao CC,Jeng JH,Young TH,Chen YJ

更新日期：2010-10-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) controls expression of plasminogen activator inhibitor type 1 (PAI-1), which regulates degradation of extracellular matrix proteins in fibrotic diseases. The TGFbeta receptor-specific Smad 3 has been implicated in the PAI-1 expression. The mechanism by which non-Smad signaling...

journal_title：Journal of cellular physiology

authors： Das F,Ghosh-Choudhury N,Venkatesan B,Li X,Mahimainathan L,Choudhury GG

更新日期：2008-02-01 00:00:00

abstract：:Lesional psoriatic epidermis displays a number of phenotypic changes that are distinct from the differentiation program found in normal interfollicular epidermis. In psoriatic epidermis, keratinocytes are hyperproliferative and several differentiation-associated molecules are expressed that are absent in normal skin (...

journal_title：Journal of cellular physiology

authors： Van Ruissen F,de Jongh GJ,Zeeuwen PL,Van Erp PE,Madsen P,Schalkwijk J

更新日期：1996-08-01 00:00:00

abstract：:Heart failure is a major cause of death throughout the world. Hyperthyroidism has been shown to induce cardiac hypertrophy, which is a contributing factor to heart failure. However, the mechanism underling effect of thyroid hormone is not completely clear. The present study investigates the role of peroxisome prolifer...

journal_title：Journal of cellular physiology

authors： Xu W,Hou D,Jiang X,Lu Z,Guo T,Liu Y,Wang D,Zen K,Yu B,Zhang CY

更新日期：2012-09-01 00:00:00

abstract：:There is strong evidence that thyroid hormones through triiodothyronine (T3) regulate Sertoli cell proliferation and differentiation in the neonatal testis. However, the mechanism(s) by which they are able to control Sertoli cell proliferation is unclear. In the present study in vivo approaches (PTU-induced neonatal h...

journal_title：Journal of cellular physiology

authors： Gilleron J,Nebout M,Scarabelli L,Senegas-Balas F,Palmero S,Segretain D,Pointis G

更新日期：2006-10-01 00:00:00

abstract：:Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage, and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcriptional changes in h...

journal_title：Journal of cellular physiology

authors： Yano S,Banno T,Walsh R,Blumenberg M

更新日期：2008-01-01 00:00:00

abstract：:Prostaglandin F2α (PGF2α) plays multiple roles on bone metabolism by regulating a wide range of signaling pathways. PGF2α, via activation of PKC, stimulates Na-dependent inorganic phosphate (Pi) transport system in osteoblasts; up-regulates interleukin (IL)-6 synthesis; increases vascular endothelial growth factor (VE...

journal_title：Journal of cellular physiology

authors： Agas D,Marchetti L,Hurley MM,Sabbieti MG

更新日期：2013-01-01 00:00:00

abstract：:During the early period after poliovirus infection of HeLa cells, cellular Na+/K+ ATPase activity is transiently activated. We investigated the possibility that Na+/K+ ATPase activation is a consequence of Na+/H+ antiporter activation. Increased uptake of the weak organic acid 5,5-dimethyloxazolidine-2,4-dione by infe...

journal_title：Journal of cellular physiology

authors： Holsey C,Cragoe EJ Jr,Nair CN

更新日期：1990-03-01 00:00:00

abstract：:Increasing evidence has demonstrated that abnormal expression of lncRNA is correlated with various malignant tumors, including hepatocellular carcinoma (HCC). Our current study was aimed to investigate the role of LINC00707 in HCC development. We observed that LINC00707 was upregulated in HCC cell lines compared with ...

journal_title：Journal of cellular physiology

authors： Wang J,Luo Z,Yao T,Li W,Pu J

更新日期：2019-05-01 00:00:00

abstract：:Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

journal_title：Journal of cellular physiology

authors： Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

更新日期：1994-12-01 00:00:00

abstract：:The proliferation of most cells is strictly dependent on cell-matrix interactions, a phenomenon called anchorage dependence. Because tumor cells are often independent of this regulation, it is important to characterize the molecular components that are involved in this control. We therefore investigated a possible rol...

journal_title：Journal of cellular physiology

authors： Villalobos Campos S,Schönthal AH

更新日期：2000-01-01 00:00:00

abstract：:Laminin is a basement membrane-specific glycoprotein that promotes cell adhesion, proliferation, differentiation, and tumor cell migration. Synthetic peptides from the amino acid sequence deduced from a cDNA clone of the B1 chain of laminin were tested for their ability to promote the migration of B16F10 melanoma cell...

journal_title：Journal of cellular physiology

authors： Iwamoto Y,Graf J,Sasaki M,Kleinman HK,Greatorex DR,Martin GR,Robey FA,Yamada Y

更新日期：1988-02-01 00:00:00

abstract：:It has been shown that the insulin-like growth factor (IGF-I) gene is spliced in response to mechanical signals producing forms of IGF-I which have different actions. In order to study how mechanical signals influence this gene splicing in developing muscle, C2C12 cells were grown in three-dimensional (3D) culture and...

journal_title：Journal of cellular physiology

authors： Cheema U,Brown R,Mudera V,Yang SY,McGrouther G,Goldspink G

更新日期：2005-01-01 00:00:00

abstract：:CCN1 is highly expressed in cancer cells and has been identified in the secretome of bone marrow-derived mesenchymal stem cells (BM-MSC). Although secreted CCN1 is known to promote angiogenesis, its underlying mechanism remains unclear. Here, we examined whether our recently-established tonsil-derived MSC (T-MSC) secr...

journal_title：Journal of cellular physiology

authors： Park YS,Hwang S,Jin YM,Yu Y,Jung SA,Jung SC,Ryu KH,Kim HS,Jo I

更新日期：2015-01-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) are considered as the main cell source for myelination in the central nervous system. Following demyelination, proliferation, migration, and differentiation capability of endogenous OPCs remarkably increase leading to remyelination in damaged areas. Despite the beneficial impacts...

journal_title：Journal of cellular physiology

authors： Yavarpour-Bali H,Nakhaei-Nejad M,Yazdi A,Ghasemi-Kasman M

更新日期：2020-03-01 00:00:00

abstract：:Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation. It is well established that HCO3- is essential for capacitation because it activates the atypical soluble adenylate cyclase ADCY10 leading to cAMP production, an...

journal_title：Journal of cellular physiology

authors： Puga Molina LC,Pinto NA,Torres Rodríguez P,Romarowski A,Vicens Sanchez A,Visconti PE,Darszon A,Treviño CL,Buffone MG

更新日期：2017-06-01 00:00:00

abstract：:The release of vasodilating substances from the vascular endothelium has been postulated to depend on a rise in the level of intracellular free calcium (Cai++). We measured Cai++ in intact monolayers of calf endothelial cells, grown in culture, that were loaded with the fluorescent calcium indicator quin 2. Fluorescen...

journal_title：Journal of cellular physiology

authors： Lückhoff A,Busse R

更新日期：1986-03-01 00:00:00

abstract：:Atherothrombotic cardiovascular disease is a major cause of mortality throughout the world. Platelet activation and aggregation play a central role in hemostasis and thrombosis. Herbal medicines have been traditionally used in the management of cardiovascular disease and can help in modifying its progression, particul...

journal_title：Journal of cellular physiology

authors： Keihanian F,Saeidinia A,Bagheri RK,Johnston TP,Sahebkar A

更新日期：2018-06-01 00:00:00

abstract：:Neuropathological and clinical evidence indicates that the clinical expression of Alzheimer's disease (AD) occurs as neuropathology exceeds the brain reserve capacity. The brain or cognitive reserve (BCR) hypothesis states that high premorbid intelligence, education, and an active and stimulating lifestyle provide res...

journal_title：Journal of cellular physiology

authors： Giovacchini G,Giovannini E,Borsò E,Lazzeri P,Riondato M,Leoncini R,Duce V,Mansi L,Ciarmiello A

更新日期：2019-02-19 00:00:00

abstract：:Mutant forms of the p53 gene have been shown to cooperate with an activated ras gene in transforming primary cells in culture. The aberrant proteins encoded by p53 mutants are thought to act in a dominant negative manner in these assays. In vivo data, however, reveal that where p53 has undergone genetic change in tumo...

journal_title：Journal of cellular physiology

authors： Slingerland JM,Benchimol S

更新日期：1991-09-01 00:00:00

abstract：:Proliferative vitroretinopathy (PVR) is caused by retinal pigment epithelial (RPE) cell proliferation and transformation into fibrotic cells that produce extracellular matrix (ECM) components. Transforming growth factor beta1 (TGF-beta1) is known to play an important role in PVR pathogenesis. To determine how TGF-beta...

journal_title：Journal of cellular physiology

authors： Lee J,Ko M,Joo CK

更新日期：2008-08-01 00:00:00

abstract：:The 94-kDa glucose-regulated protein (GRP94) is a glycoprotein in the endoplasmic reticulum (ER). It has been characterized as a Ca2+-binding protein and a molecular chaperone. In this report we show that highly purified GRP94 exhibits an active Mg2+-dependent serine kinase activity (termed 94-kinase). The 94-kinase c...

journal_title：Journal of cellular physiology

authors： Ramakrishnan M,Schönthal AH,Lee AS

更新日期：1997-02-01 00:00:00

abstract：:Early biochemical changes associated with adjuvant stimulation of macrophage protein synthesis were studied using two murine macrophage cell lines, PU5-1.8 and J774.1. An induction of ornithine decarboxylase (ODC) was detected 2 hours after exposure of PU5-1.8 and J774.1 cells to two crude immunoadjuvants, BCG cell wa...

journal_title：Journal of cellular physiology

authors： Prosser FH,Schmidt CJ,Nichols SV,Nichols WK

更新日期：1984-07-01 00:00:00

abstract：:Circular RNAs (circRNAs) are reported to regulate the development and progression of multiple cancers. However, the functions of circRNAs in nasopharyngeal carcinoma (NPC) are unclear. In this study, we identified that circular homeodomain interacting protein kinase 3 (circHIPK3) was highly expressed in NPC tissues an...

journal_title：Journal of cellular physiology

authors： Ke Z,Xie F,Zheng C,Chen D

更新日期：2019-02-01 00:00:00

abstract：:A high proportion of murine resident peritoneal macrophages bear complement receptors 1 and 3 (CR1, CR3) which bind C3b and iC3b components of complement, respectively. By contrast, macrophages derived from bone marrow, blood, and the elicited peritoneal exudate are predominantly CR1+3. To determine if the microenviro...

journal_title：Journal of cellular physiology

authors： Yen SE,Walker WS

更新日期：1983-04-01 00:00:00

abstract：:Small intestinal crypt cells play a critical role in modulating Cl- secretion during digestion. The types of Cl- channels mediating Cl- secretion in the small intestine was investigated using the intestinal epithelial cell line, IEC-18, which was derived from rat small intestine crypt cells. In initial radioisotope ef...

journal_title：Journal of cellular physiology

authors： Basavappa S,Vulapalli SR,Zhang H,Yule D,Coon S,Sundaram U

更新日期：2005-01-01 00:00:00

abstract：:A temperature-sensitive mutant with a defect in glycoprotein synthesis and a cell cycle (G1)-specific arrest at the nonpermissive temperature (Tenner et al., J. Cell. Physiol., 90:145-160, 1977; Tenner and Scheffler, J. Cell. Physiol., 98:251-266, 1979) was investigated further after a human epidermal growth factor (E...

journal_title：Journal of cellular physiology

authors： Feige JJ,Scheffler IE

更新日期：1987-12-01 00:00:00