Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex.

abstract：:Marrow stromal cells (MSCs) are stem-like cells having a striking somatic plasticity. In fact, besides differentiating into mesenchymal lineages (bone, cartilage, and fat), they are capable of differentiating into neurons and astrocytes in vitro and in vivo. The RB and RB2/P130 genes, belonging to the retinoblastoma g...

journal_title：Journal of cellular physiology

authors： Jori FP,Napolitano MA,Melone MA,Cipollaro M,Cascino A,Giordano A,Galderisi U

更新日期：2004-08-01 00:00:00

abstract：:Arginine vasopressin (AVP) regulates glomerular hemodynamics, alters extracellular matrix production, and induces proliferation of glomerular mesangial cells (MCs). Therefore, AVP may play a role in glomerular sclerosis and the progression of chronic renal failure. To investigate changes in early gene expression which...

journal_title：Journal of cellular physiology

authors： Rupprecht HD,Sukhatme VP,Rupprecht AP,Sterzel RB,Coleman DL

更新日期：1994-05-01 00:00:00

abstract：:The glucose analogues, 3-O-methyl-D-glucose and 2-deoxy-D-glucose, have been used to characterize glucose transport and its regulation by serum and growth factors in monolayer cultures of granulosa cells obtained from bovine ovaries. Uptake of 3-O-methylglucose was shown to be independent of the Na+-gradient, independ...

journal_title：Journal of cellular physiology

authors： Allen WR,Nilsen-Hamilton M,Hamilton RT

更新日期：1981-07-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6-methyladenosine (m6 A) modification is the most common modification of ...

journal_title：Journal of cellular physiology

authors： Xu R,Pang G,Zhao Q,Yang L,Chen S,Jiang L,Shen Y,Shao W

更新日期：2020-11-01 00:00:00

abstract：:Embryo implantation is essential for normal pregnancy, and the process of decidualization is critical for embryo implantation. However, the mechanism of decidualization during early pregnancy is still unknown. Forkhead box O3a (FOXO3a) is the most important functional transcription factor of the forkhead box family an...

journal_title：Journal of cellular physiology

authors： Long J,Yang CS,He JL,Liu XQ,Ding YB,Chen XM,Tong C,Peng C,Wang YX,Gao RF

更新日期：2019-04-01 00:00:00

abstract：:The endogenous thiols (PSH, protein sulfhydryls; NPSH, nonprotein sulfhydryls; and GSH, glutathione) were measured in the 66 and 67 murine carcinoma cells growing under different physiological conditions in vitro (e.g., proliferation, P; nutrient-deprived quiescence QI; and QI cells stimulated by refeeding the monolay...

journal_title：Journal of cellular physiology

authors： Dethlefsen LA,Biaglow JE,Peck VM,Ridinger DN

更新日期：1987-07-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB), a family of master regulated dimeric transcription factors, signaling transduction pathways are active players in the cell signaling that control vital cellular processes, including cell growth, proliferation, differentiation, apoptosis, morphogenesis, angiogenesis, and immune responses. Nev...

journal_title：Journal of cellular physiology

authors： Shokri S,Mahmoudvand S,Taherkhani R,Farshadpour F,Jalalian FA

更新日期：2019-02-11 00:00:00

abstract：:Although immortalized cultured cells are useful for various functional assays or transcriptome analysis, highly efficient and reproducible immortalization methods have not been developed in avian-derived cells. We introduced the simian virus 40 T antigen (SV40T) and human papillomavirus (HPV)-E6E7 to chick and Okinawa...

journal_title：Journal of cellular physiology

authors： Katayama M,Kiyono T,Ohmaki H,Eitsuka T,Endoh D,Inoue-Murayama M,Nakajima N,Onuma M,Fukuda T

更新日期：2019-05-01 00:00:00

abstract：:BAG3 protein, a member of the BAG co-chaperones family, sustains cell survival in a variety of normal and neoplastic cell types, via its interaction with a variety of partners, such as the heat shock protein (HSP) 70, Bcl-2, Raf-1 and others. Expression of BAG3 is induced by some stressful stimuli, such as heat shock,...

journal_title：Journal of cellular physiology

authors： Du ZX,Zhang HY,Meng X,Gao YY,Zou RL,Liu BQ,Guan Y,Wang HQ

更新日期：2009-03-01 00:00:00

abstract：:We determined the mitogenic and comitogenic properties of tumor promoters in the indole alkaloid series; agents that differ structurally from 12-0-tetradecanoylphorbol-13-acetate (TPA), which is known to be a lymphocyte mitogen. Teleocidin and dihydroteleocidin B were mitogenic for human lymphocytes, and lyngbyatoxin ...

journal_title：Journal of cellular physiology

authors： Novogrodsky A,Patya M,Fujiki H,Rubin AL,Stenzel KH

更新日期：1984-07-01 00:00:00

abstract：:Ascorbic acid induces apoptosis, autophagy, and necrotic cell death in cancer cells. We investigated the mechanisms by which ascorbic acid induces death in laryngeal squamous cell carcinoma Hep2 cells. Ascorbic acid markedly reduced cell viability and induced death without caspase activation and an increase in cytochr...

journal_title：Journal of cellular physiology

authors： Baek MW,Cho HS,Kim SH,Kim WJ,Jung JY

更新日期：2017-02-01 00:00:00

abstract：:Erythropoietin (EPO) retards DNA breakdown characteristic of programmed cell death (apoptosis) and promotes survival in erythroid progenitor cells. The mechanism by which EPO inhibits programmed death is unknown. In the well-characterized model of glucocorticoid-treated thymocytes, activation of a Ca2+/Mg(2+)-sensitiv...

journal_title：Journal of cellular physiology

authors： Kelley LL,Koury MJ,Bondurant MC

更新日期：1992-06-01 00:00:00

abstract：:Clinicians have observed that keloids preferentially form in body areas subject to increased skin tension. We hypothesized a difference exists in the transcriptional response of keloid fibroblasts to mechanical strain compared with normal fibroblasts. Normal and keloid fibroblasts were seeded in a device calibrated to...

journal_title：Journal of cellular physiology

authors： Wang Z,Fong KD,Phan TT,Lim IJ,Longaker MT,Yang GP

更新日期：2006-02-01 00:00:00

abstract：:We previously showed that fluid flow, which chondrocytes experience in vivo and which results in a variety of morphological and metabolic changes in cultured articular chondrocytes, can also stimulate a rise in intracellular calcium concentration ([Ca2+]i). However, the mechanism by which Ca2+ is mobilized in response...

journal_title：Journal of cellular physiology

authors： Yellowley CE,Jacobs CR,Donahue HJ

更新日期：1999-09-01 00:00:00

abstract：:Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

journal_title：Journal of cellular physiology

authors： Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

更新日期：1994-12-01 00:00:00

abstract：:Cultures of HeLa cells, strains S3G (HeLa65) and S3K (HeLa71) were grown in plastic dishes until firmly attached and were then treated with sonic dispersions of Rosenthal's phospholipase inhibitor. A rapid increase in alkaline phosphatase activity occurred following this treatment in the S3G strain (low inducible alka...

journal_title：Journal of cellular physiology

authors： Melnykovych G,Lopez IC

更新日期：1977-07-01 00:00:00

abstract：:Cyclosporine A (CyA) is a powerful nonsteroidal immunosuppressive agent used to prevent graft rejection of organ and bone marrow transplants. A major side effect observed can be attributed to the fibroblast and its functions: proliferation of fibroblasts and formation of fibrotic tissue in the gingiva (fibrous hyperpl...

journal_title：Journal of cellular physiology

authors： Willershausen-Zönnchen B,Lemmen C,Schumacher U

更新日期：1992-08-01 00:00:00

abstract：:The ratio of mouse to rat albumin secreted by mouse hepatoma x rat hepatoma hybrid cells is constant (of the order of 5.0) irrespective of the total amounts produced. The present results establish for seven independent hybrid clones that the coordination in the ratio of mouse to rat product applies also at the level o...

journal_title：Journal of cellular physiology

authors： Sellem CH,Cassio D,Sala-Trepat JM,Weiss MC

更新日期：1983-05-01 00:00:00

abstract：:Hemodynamic forces influence many endothelial cell functions. The coupling between hemodynamic forces and cell function could be mediated by mechano-sensitive ion channels present in the plasma membrane of endothelial cells. Because one of these channels is permeable to Ca2+, we tested whether hemodynamic forces influ...

journal_title：Journal of cellular physiology

authors： Oliver JA,Chase HS Jr

更新日期：1992-04-01 00:00:00

abstract：:Baclofen is used clinically as a drug that treats spasticity, which is a syndrome characterized by excessive contraction of the muscles and hyperflexia in the central nervous system (CNS), by activating GABA(B) receptors (GABA(B)Rs). Baclofen was recently reported to desensitize chemokine receptors and to suppress inf...

journal_title：Journal of cellular physiology

authors： Huang S,Mao J,Wei B,Pei G

更新日期：2015-07-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is associated with atherosclerotic events involving the modulation of arachidonic acid (AA) metabolism and the activation of matrix metalloproteinase-9 (MMP-9). Cytochrome P450 (CYP) epoxygenase-2J2 (CYP2J2) is abundant in the heart endothelium, and its AA metabolites epoxyeicosatrienoic ac...

journal_title：Journal of cellular physiology

authors： Moshal KS,Zeldin DC,Sithu SD,Sen U,Tyagi N,Kumar M,Hughes WM Jr,Metreveli N,Rosenberger DS,Singh M,Vacek TP,Rodriguez WE,Ayotunde A,Tyagi SC

更新日期：2008-06-01 00:00:00

abstract：:This study establishes a causal link between the limitation of myofibre transitions and modulation of calcineurin activity, during different exercise paradigms. We have designed a new swimming-based training protocol in order to draw a comparison between a high frequency and amplitude exercise (swimming) and low frequ...

journal_title：Journal of cellular physiology

authors： Grondard C,Biondi O,Pariset C,Lopes P,Deforges S,Lécolle S,Gaspera BD,Gallien CL,Chanoine C,Charbonnier F

更新日期：2008-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the possible involvement of the phosphoinositide 3-kinase (PI3K)/Akt survival pathway in determining resistance to arsenic trioxide (As2O3)-induced apoptosis. We employed a HL60 cell clone (HL60AR) with a constitutively active PI3K/Akt survival pathway, as well as U937 and K56...

journal_title：Journal of cellular physiology

authors： Tabellini G,Cappellini A,Tazzari PL,Falà F,Billi AM,Manzoli L,Cocco L,Martelli AM

更新日期：2005-02-01 00:00:00

abstract：:Sleep-disordered breathing with recurrent apnea (periodic cessation of breathing) results in chronic intermittent hypoxia (IH), which leads to cardiovascular and respiratory pathology. Molecular mechanisms underlying IH-evoked cardio-respiratory co-morbidities have not been delineated. Mice with heterozygous deficienc...

journal_title：Journal of cellular physiology

authors： Yuan G,Nanduri J,Khan S,Semenza GL,Prabhakar NR

更新日期：2008-12-01 00:00:00

abstract：:Basic fibroblast growth factor (bFGF, FGF-2) is progressively lost from mammary epithelial cells as they become malignant. To investigate the effects of restoring the expression of bFGF in breast cancer cells, we constructed MCF-7 cells that permanently overexpress 18-kD cytoplasm-localizing bFGF (MCF-7/deltaA(FGF)(18...

journal_title：Journal of cellular physiology

authors： Wieder R,Fenig E,Wang H,Wang Q,Paglin S,Menzel T,Gabrilove J,Fuks Z,Yahalom J

更新日期：1998-12-01 00:00:00

abstract：:KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To i...

journal_title：Journal of cellular physiology

authors： Huang KC,Li TM,Liu X,Chen JH,Chien WK,Shiao YT,Tsang H,Lin TH,Liao CC,Huang SM,Li JP,Lin CW,Lin JC,Lin CC,Lai CH,Cheng CF,Liang WM,Hung CH,Chen CC,Lin YJ,Tsai FJ

更新日期：2017-12-01 00:00:00

abstract：:Cardiac hypertrophy (CH) has become a huge threat to human health. Recent years, long noncoding RNAs (lncRNAs) have been studied in human diseases, including CH. According to bioinformatics analysis, 10 lncRNAs possibly involved in the progression of CH were screened out. Among which, lncRNA SYNE1 antisense RNA 1 (SYN...

journal_title：Journal of cellular physiology

authors： Wang Y,Cao R,Yang W,Qi B

更新日期：2019-08-01 00:00:00

abstract：:This study describes the alterations induced by Interleukin-1 alpha and -beta (IL-1 alpha and IL-1 beta) on fibroblast-synthesized extracellular matrix. Fibroblasts were grown between pieces of dentin or in collagen-coated Terasaki wells for 3 or 6-9 weeks to create 3-dimensional cell-containing matrices constituted p...

journal_title：Journal of cellular physiology

authors： Qwarnström EE,MacFarlane SA,Page RC

更新日期：1989-06-01 00:00:00

abstract：:The effects of the polyamines putrescine (PUT), spermidine (SPD), and spermidine (SPM) on the secretion of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) were evaluated using cultured bovine aortic endothelial cells. All three polyamines enhanced PA secretion in a time- and dose-dependent manner,...

journal_title：Journal of cellular physiology

authors： Kuo BS,Korner G,Dryjski M,Bjornsson TD

更新日期：1988-10-01 00:00:00

abstract：:When human diploid fibroblasts IMR-90 are cultured in routinely used medium (Eagle's basal medium supplemented with 10% fetal calf serum), sulfhydryl compounds appear in the medium. The major component of these sulfhydryl compounds is cysteine, and it is shown that a part of medium cystine is converted into cysteine b...

journal_title：Journal of cellular physiology

authors： Bannai S,Ishii T

更新日期：1980-08-01 00:00:00