Influence of cyclosporine A on growth and extracellular matrix synthesis of human fibroblasts.

abstract：:An artificial wound in a confluent monolayer of human keratinocyte HaCaT cells or mouse embryo fibroblast Swiss NIH 3T3 cells was used to analyze the effects of the nitric oxide (NO) chemical donor, S-nitroso-N-acetylpenicillamine (SNAP). SNAP exposure promoted an enhanced rate of wound closure and accelerated motilit...

journal_title：Journal of cellular physiology

authors： La Torre C,Cinque B,Lombardi F,Miconi G,Palumbo P,Evtoski Z,Placidi G,Fanini D,Cimini AM,Benedetti E,Giuliani M,Cifone MG

更新日期：2016-10-01 00:00:00

abstract：:The expression of parathyroid hormone-related protein (PTHrP) was studied in a range of cell cultures representative of the osteoblast lineage and in rat calvarial sections. Primary newborn rat calvarial cells, a rat preosteoblastic cell line (UMR 201), a mouse stromal cell line (ST 2), a mouse calvaria-derived osteob...

journal_title：Journal of cellular physiology

authors： Suda N,Gillespie MT,Traianedes K,Zhou H,Ho PW,Hards DK,Allan EH,Martin TJ,Moseley JM

更新日期：1996-01-01 00:00:00

abstract：:The synthesis and degradation of pectoralis myosin have been investigated in chickens 15-23 days after hatching. An essentially nonreutilizable tracer amino acid was used to demonstrate differences in the rates of synthesis and degradation of myosin isolated from normal and hypertrophied, cystrophic breast tissue. The...

journal_title：Journal of cellular physiology

authors： Rourke AW

更新日期：1975-10-01 00:00:00

abstract：:Rat 3Y1 cells arrested at early S by hydroxyurea traversed the remainder of S and G2 and completed mitosis after removal of the drug, irrespective of the absence of serum from the culture medium. When cells were deprived of serum for a period between early S and mitosis after removal of hydroxyurea, the cells delayed ...

journal_title：Journal of cellular physiology

authors： Okuda A,Kimura G

更新日期：1982-03-01 00:00:00

abstract：:Mouse heptoma cells that secrete large amounts of alpha-fetoprotein (AFP) and albumin have been crossed with rat hepatoma cells that secret only albumin, and in relatively small amounts, to investigate the influence of each parental genome upon the expression of serum proteins. All of the ten independent hybrid clones...

journal_title：Journal of cellular physiology

authors： Cassio D,Hassoux R,Dupiers M,Uriel J,Weiss MC

更新日期：1980-09-01 00:00:00

abstract：:Exosomes contain regulatory signals such as lipids, proteins, and nucleic acids which can be transferred to adjacent or remote cells to mediate cell-to-cell communication. Exercise is a positive lifestyle for metabolic health and a nonpharmacological treatment of insulin resistance and metabolic diseases. Moreover, ex...

journal_title：Journal of cellular physiology

authors： Li G,Liu H,Ma C,Chen Y,Wang J,Yang Y

更新日期：2019-02-12 00:00:00

abstract：:We describe the isolation and characterization of a Chinese hamster ovary cell line selected for resistance to N-carbamoyloxyurea. Using the mammalian cell permeabilization assay developed in our laboratory, a detailed analysis of the target enzyme, ribonucleotide reductase (EC 1.17.4.1), was carried out. Both drug-re...

journal_title：Journal of cellular physiology

authors： Hards RG,Wright JA

更新日期：1981-02-01 00:00:00

abstract：:Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. M...

journal_title：Journal of cellular physiology

authors： Vandenburgh HH,Shansky J,Karlisch P,Solerssi RL

更新日期：1993-04-01 00:00:00

abstract：:The effects of three purified colony-stimulating factors (CSFs) with different specificities for the granulocyte (G) and macrophage (M) lineages (G-CSF, CSF-1 and GM-CSF) were studied in a serum-free clonal assay system. The results were compared with those obtained in similar cultures containing fetal calf serum (FCS...

journal_title：Journal of cellular physiology

authors： Eliason JF

更新日期：1986-08-01 00:00:00

abstract：:Concanavalin A (ConA)-induced hepatitis is an experimental model of human autoimmune hepatitis induced in rodents by i.v. injection of Con A. The disease is characterized by increase in serum levels of transaminases and massive immune infiltration of the livers. Type 1, type 2, and type 17 cytokines play a pathogenic ...

journal_title：Journal of cellular physiology

authors： Mangano K,Cavalli E,Mammana S,Basile MS,Caltabiano R,Pesce A,Puleo S,Atanasov AG,Magro G,Nicoletti F,Fagone P

更新日期：2018-05-01 00:00:00

abstract：:Cytoplasmic poly-A containing RNA, synthesized by cultured chick embryo cells, was examined during growth in 5-bromodeoxyuridine. The kinetics of 3H-adenosine incorporation into this species of RNA, when compared to the rest of the cytoplasmic RNA, and to control cells, indicates that the rate of synthesis of this RNA...

journal_title：Journal of cellular physiology

authors： Pawlowski PJ

更新日期：1976-09-01 00:00:00

abstract：:Cultures of HeLa cells, strains S3G (HeLa65) and S3K (HeLa71) were grown in plastic dishes until firmly attached and were then treated with sonic dispersions of Rosenthal's phospholipase inhibitor. A rapid increase in alkaline phosphatase activity occurred following this treatment in the S3G strain (low inducible alka...

journal_title：Journal of cellular physiology

authors： Melnykovych G,Lopez IC

更新日期：1977-07-01 00:00:00

abstract：:Despite the improvements in fracture healing, about 10% of patients undergo abnormal healing. As a tumor suppressor, upregulation of microRNA (miR)-203 has been observed in osteogenic differentiation. Herein, we aimed to explore the functional role of miR-203 in osteoblasts as well as the underlying mechanisms. The ex...

journal_title：Journal of cellular physiology

authors： Liu H,Chen B,Li Y

更新日期：2019-08-01 00:00:00

abstract：:Lipocalin-2 (LCN2) is a protein largely expressed in many tissues, associated with different biological phenomena such as cellular differentiation, inflammation and cancer acting as a survival/apoptotic signal. We found that LCN2 was expressed during osteoblast differentiation and we generated transgenic (Tg) mice ove...

journal_title：Journal of cellular physiology

authors： Costa D,Lazzarini E,Canciani B,Giuliani A,Spanò R,Marozzi K,Manescu A,Cancedda R,Tavella S

更新日期：2013-11-01 00:00:00

abstract：:Recent studies have indicated that endoplasmic reticulum stress, the unfolded protein response activation and altered GRP78 expression can play an important role in a variety of tumors development and progression. Very recently we reported for the first time that GRP78 is increased in endometrial tumors. However, whet...

journal_title：Journal of cellular physiology

authors： Calì G,Insabato L,Conza D,Bifulco G,Parrillo L,Mirra P,Fiory F,Miele C,Raciti GA,Di Jeso B,Terrazzano G,Beguinot F,Ulianich L

更新日期：2014-10-01 00:00:00

abstract：:Histone deacetylase 2 (HDAC2) catalyzes deacetylation of histones at the promoter and coding regions of transcribed genes and regulates chromatin structure and transcription. To explore the role of HDAC2 and phosphorylated HDAC2 in gene regulation, we studied the location along transcribed genes, the mode of recruitme...

journal_title：Journal of cellular physiology

authors： Jahan S,Sun JM,He S,Davie JR

更新日期：2018-02-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) controls expression of plasminogen activator inhibitor type 1 (PAI-1), which regulates degradation of extracellular matrix proteins in fibrotic diseases. The TGFbeta receptor-specific Smad 3 has been implicated in the PAI-1 expression. The mechanism by which non-Smad signaling...

journal_title：Journal of cellular physiology

authors： Das F,Ghosh-Choudhury N,Venkatesan B,Li X,Mahimainathan L,Choudhury GG

更新日期：2008-02-01 00:00:00

abstract：:We previously demonstrated that 4-oxoretinol (4-oxo-ROL) activated retinoic acid receptors (RARs) in F9 stem cells. We showed that 4-oxo-ROL inhibited the proliferation of normal human mammary epithelial cells (HMECs). To understand the mechanisms by which 4-oxo-ROL regulates HMEC growth we examined gene expression pr...

journal_title：Journal of cellular physiology

authors： Liu L,Derguini F,Gudas LJ

更新日期：2009-09-01 00:00:00

abstract：:We examined the behavior of the transcription factor Max during retrograde neuronal degeneration of retinal ganglion cells. Using immunohistochemistry, we found a progressive redistribution of full-length Max from the nucleus to the cytoplasm and dendrites of the ganglion cells following axon damage. Then, the axotomi...

journal_title：Journal of cellular physiology

authors： Petrs-Silva H,de Freitas FG,Linden R,Chiarini LB

更新日期：2004-02-01 00:00:00

abstract：:Cell therapy is one of the important therapeutic approaches in the treatment of many diseases such as cancer, degenerative diseases, and cardiovascular diseases. Among various cell types, which could be used as cell therapies, stem cell therapy has emerged as powerful tools in the treatment of several diseases. Multip...

journal_title：Journal of cellular physiology

authors： Baniebrahimi G,Khanmohammadi R,Mir F

更新日期：2019-03-01 00:00:00

abstract：:Keratin intermediate filaments play an important role in maintaining the integrity of the skin structure. Understanding the importance of this subject is possible with the investigation of keratin defects in epidermolysis bullosa simplex (EBS). Nowadays, in addition to clinical criteria, new molecular diagnostic metho...

journal_title：Journal of cellular physiology

authors： Khani P,Ghazi F,Zekri A,Nasri F,Behrangi E,Aghdam AM,Mirzaei H

更新日期：2018-01-01 00:00:00

abstract：:Biosensors are composed of (bio)receptors, transducers, and detection systems and are able to convert the biological stimulus into a measurable signal. This systematic review evaluates the current state of the art of innovation and research in this field, identifying the biosensors that in vitro monitor the musculoske...

journal_title：Journal of cellular physiology

authors： Veronesi F,Tschon M,Visani A,Fini M

更新日期：2019-12-01 00:00:00

abstract：:Although the role of several protooncogenes, including sis, myc, and myb in the regulation of growth and differentiation of vascular cells has been examined in some detail, limited information is available on the contribution of ras genes to these processes. In the present studies the influence of oncogenic ras transf...

journal_title：Journal of cellular physiology

authors： Sadhu DN,Lundberg MS,Burghardt RC,Ramos KS

更新日期：1994-12-01 00:00:00

abstract：:Endothelial cell-derived growth factor (ECDGF) is a soluble mitogen secreted in vitro by bovine aortic endothelium. ECDGF is a mixture of at least two distinct heat-stable and trypsin-sensitive mitogens. Large amounts of mitogenic activity were found in lysates prepared from cultured endothelial cells. Other nonmitoge...

journal_title：Journal of cellular physiology

authors： Gajdusek CM,Schwartz SM

更新日期：1984-11-01 00:00:00

abstract：:Long suspected, recently recognized, and increasingly studied, non protein-coding RNAs (ncRNAs) are emerging as key drivers of biological control and pathology. Since their discovery in 1993, microRNAs (miRNAs) have been the subject of intense research focus and investigations have revealed striking findings, establis...

journal_title：Journal of cellular physiology

authors： Tye CE,Gordon JA,Martin-Buley LA,Stein JL,Lian JB,Stein GS

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) have a severe vitamin D deficiency and increasing epidemiological data suggesting that this deficiency may play a role in overall morbidity and mortality associated with CKD. It is known that vitamin D regulates the immune system, however, in dialysis patients this ...

journal_title：Journal of cellular physiology

authors： Almeida ACSF,Siqueira MC,Bonan NB,Dambiski A,Bertuzzo G,Moreno-Amaral AN,Barreto FC

更新日期：2019-02-25 00:00:00

abstract：:Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro-environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro-inflammatory and polarized by lipopolysaccharide (LPS) either alone or in association with Th...

journal_title：Journal of cellular physiology

authors： Shapouri-Moghaddam A,Mohammadian S,Vazini H,Taghadosi M,Esmaeili SA,Mardani F,Seifi B,Mohammadi A,Afshari JT,Sahebkar A

更新日期：2018-09-01 00:00:00

abstract：:Prkdc encodes for the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) playing a key role in nonhomologous end joining pathway during DNA double-strand break repair and also influencing the homologous recombination (HR) repair system by phosphorylation of proteins involved in HR. In addition, Prkdc has...

journal_title：Journal of cellular physiology

authors： Soleimani F,Babaei E,H Feizi MA,Fathi F

更新日期：2020-04-01 00:00:00

abstract：:Colon cancer remains one of the lethal malignancies in the world. Aberrant activation of canonical Wnt/β-catenin signaling pathway has been observed in colon cancer. In contrast, the non-canonical Wnt signaling functions remain obscure. Wnt5a is a representative non-canonical Wnt ligand which has gained extensive atte...

journal_title：Journal of cellular physiology

authors： Cheng R,Sun B,Liu Z,Zhao X,Qi L,Li Y,Gu Q

更新日期：2014-12-01 00:00:00

abstract：:The hexose transport system of undifferentiated L6 rat myoblasts was investigated. 2-Deoxy-D-glucose (2-DOG) and 2-deoxy-2-fluoro-D-glucose (2FG) were used as analogues to investigate the rate-limiting step of hexose uptake into the cell. Virtually all of the 2-DOG or 2FG taken up into the cell was found to be in the ...

journal_title：Journal of cellular physiology

authors： D'Amore T,Lo TC

更新日期：1986-04-01 00:00:00