The role of microRNAs in embryonic stem cell and induced pluripotent stem cell differentiation in male germ cells.

abstract：:A successful aging could be gained by life satisfaction, social functioning, or psychological resources and, definitely, by increasing resistance to diverse age-related pathologies. Nowadays, cancer can be considered an age-related disease since the incidence of most cancers increases with age, rising more rapidly beg...

journal_title：Journal of cellular physiology

authors： Tramontano D,De Amicis F

更新日期：2018-11-01 00:00:00

abstract：:NEMO/IKKγ is the regulatory subunit of the IκB Kinase (IKK) complex, required for the activation of the NF-κB pathway, which is involved in a variety of key processes, including immunity, inflammation, differentiation, and cell survival. Termination of NF-κB activity on specific -κB responsive genes, which is crucial ...

journal_title：Journal of cellular physiology

authors： Esposito E,Napolitano G,Pescatore A,Calculli G,Incoronato MR,Leonardi A,Ursini MV

更新日期：2016-01-01 00:00:00

abstract：:Grb10 is a member of a superfamily of adapter proteins that includes Grb10, 7, 14, and a protein of Caenorhabditis elegans called Mig10. Grb10 proteins are binding partners for several trans-membrane tyrosine-kinase receptors, including the insulin-like growth factor receptor (IGF-IR) and the insulin receptor (IR). Ma...

journal_title：Journal of cellular physiology

authors： Morrione A

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy. METHODS:Bioinf...

journal_title：Journal of cellular physiology

authors： Tian X,Ji Y,Liang Y,Zhang J,Guan L,Wang C

更新日期：2019-08-01 00:00:00

abstract：:The serine protease thrombin has been proposed to be involved in neuromuscular plasticity. Its specific receptor "protease activated receptor-1" (PAR-1), a G protein-coupled receptor, has been shown to be expressed in myoblasts but not after fusion (Suidan et al., 1996 J Biol Chem 271:29162-29169). In the present work...

journal_title：Journal of cellular physiology

authors： Chevessier F,Hantaï D,Verdière-Sahuqué M

更新日期：2001-11-01 00:00:00

abstract：:Many critical factors such as hypoxia, nutrient deficiency, activation of glycolytic pathway/Warburg effect contribute to the observed low pH in tumors compared to normal tissue. Studies suggest that such tumor specific acidic environment can be exploited for the development of therapeutic strategies against cancer. I...

journal_title：Journal of cellular physiology

authors： Shamim U,Hanif S,Albanyan A,Beck FW,Bao B,Wang Z,Banerjee S,Sarkar FH,Mohammad RM,Hadi SM,Azmi AS

更新日期：2012-04-01 00:00:00

abstract：:The cellular proto-oncogene c-myc is an important transcription factor that plays a role in several cellular activities such as proliferation, differentiation, and apoptosis. It follows that regulation of c-myc expression is crucial for maintaining cell integrity. Amplification or translocation can convert this proto-...

journal_title：Journal of cellular physiology

authors： Habel ME,Lemieux R,Jung D

更新日期：2005-04-01 00:00:00

abstract：:3-Hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR) is the key and rate-limiting enzyme of cholesterol biosynthetic pathway. Although HMG-CoAR activity has already been related to the differentiation of some cellular lines there are no studies that analyze the role of HMG-CoAR, and the pathway it is involved wi...

journal_title：Journal of cellular physiology

authors： Martini C,Trapani L,Narciso L,Marino M,Trentalance A,Pallottini V

更新日期：2009-08-01 00:00:00

abstract：:The transcriptional factors implicated in the expression of the intermediate filament protein nestin in cardiomyocytes during embryogenesis remain undefined. In the heart of 9,5-10,5 day embryonic mice, nestin staining was detected in atrial and ventricular cardiomyocytes and a subpopulation co-expressed Tbx5. At late...

journal_title：Journal of cellular physiology

authors： Hertig V,Matos-Nieves A,Garg V,Villeneuve L,Mamarbachi M,Caland L,Calderone A

更新日期：2018-04-01 00:00:00

abstract：:The differentiation of human keratinocytes in most culture systems is incomplete; e.g., lamellar bodies, the characteristic lipid-delivery organelles of epidermis, are not present. Moreover, their lipid profile does not reflect the distinctive composition found in cornifying epidermis. In contrast, keratinocytes that ...

journal_title：Journal of cellular physiology

authors： Williams ML,Brown BE,Monger DJ,Grayson S,Elias PM

更新日期：1988-07-01 00:00:00

abstract：:Cell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the present investigation...

journal_title：Journal of cellular physiology

authors： Sardone F,Traina F,Tagliavini F,Pellegrini C,Merlini L,Squarzoni S,Santi S,Neri S,Faldini C,Maraldi N,Sabatelli P

更新日期：2014-07-01 00:00:00

abstract：:The polyphenolic compounds curcumin and quercetin increased sensitivity of ovarian cancer cells (CAOV3 and SKOV3) to cisplatin. The effect was obtained when the compounds were added simultaneously with cisplatin, as well as when they were added 24 h before. High serum levels of certain cytokines, for example interleuk...

journal_title：Journal of cellular physiology

authors： Chan MM,Fong D,Soprano KJ,Holmes WF,Heverling H

更新日期：2003-01-01 00:00:00

abstract：:Our study examines the effect of apoptosis on prothymosin alpha, an abundant, nuclear protein intimately involved with proliferation of all mammalian cells. When HeLa cells were treated with actinomycin D, with etoposide, or with staurosporine following synchronization with hydroxyurea, they underwent apoptosis based ...

journal_title：Journal of cellular physiology

authors： Enkemann SA,Wang RH,Trumbore MW,Berger SL

更新日期：2000-02-01 00:00:00

abstract：:The frequencies of 6-thioguanine-resistant primary clones from the kidneys and skeletal muscles of aging male cohorts of two F1 hybrid strains of Mus musculus varied from 0.59 to 10.96 X 10(-5) and did not increase as a function of donor age (up to 40 months). Resistant clones were shown to be severely deficient in th...

journal_title：Journal of cellular physiology

authors： Horn PL,Turker MS,Ogburn CE,Disteche CM,Martin GM

更新日期：1984-11-01 00:00:00

abstract：AIM:We investigated melanoma-associated antigen A1 (MAGE-A1) expression in lung cancer tissues and its correlation with prognostic factors. MATERIALS AND METHODS:In this cross-sectional study, samples from 101 patients with lung cancer were obtained between 2007 and 2014 and stained for MAGE-A1 by immunohistochemistry...

journal_title：Journal of cellular physiology

authors： Fanipakdel A,Seilanian Toussi M,Rezazadeh F,Mohamadian Roshan N,Javadinia SA

更新日期：2019-07-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a pleiotropic enzyme involved in DNA repair, cell cycle control, and transcription regulation. A potential role for DNA-PKcs in the regulation of osteoblastogenesis remains to be established. We show that pharmacological inhibition of DNA-PKcs kinase ...

journal_title：Journal of cellular physiology

authors： Farhat T,Dudakovic A,Chung JH,van Wijnen AJ,St-Arnaud R

更新日期：2021-02-01 00:00:00

abstract：:The growth-regulated vimentin gene contains a functional double AP-1 binding site formed by two nearly perfect inverted repeats. We present evidence for down-regulation of vimentin expression by the retinoic acid receptor (RAR) in two mesodermally derived cell types. By mutation analysis we prove that the double conse...

journal_title：Journal of cellular physiology

authors： Van de Klundert FA,Jansen HJ,Bloemendal H

更新日期：1995-07-01 00:00:00

abstract：:Proliferation of human skin fibroblasts was stimulated significantly by the presence of L-ascorbic acid 2-phosphate (Asc 2-P). The presence of Asc 2-P (0.1-1.0 mM) in the culture medium for 3 weeks enhanced the relative rate of collagen synthesis to total protein synthesis 2-fold as well as cell growth 4-fold. Coexist...

journal_title：Journal of cellular physiology

authors： Hata R,Senoo H

更新日期：1989-01-01 00:00:00

abstract：:In RBL-2H3 rat leukemic mast cells, cross-linking anti-DNP IgE-receptor complexes with multivalent antigen (DNP-BSA) activates a signal transduction pathway leading to Ca2+ influx and secretion. Cross-linking IgE-receptor complexes also stimulates a pathway that inactivates (desensitizes) receptors; this pathway becom...

journal_title：Journal of cellular physiology

authors： Wilson BS,Seagrave J,Oliver JM

更新日期：1991-12-01 00:00:00

abstract：:Circular RNA TCF25 (circTCF25) has been proven to be upregulated in human malignancy and correlated with tumor process. Our study aimed to unravel whether circTCF25 dictates cellular activities of osteosarcoma cells and address the possible mechanisms associated with microRNA (miR). circTCF25 and miR-206 in clinical s...

journal_title：Journal of cellular physiology

authors： Wang Y,Shi S,Zhang Q,Dong H,Zhang J

更新日期：2020-02-13 00:00:00

abstract：:The endocannabinoid system (ECS) is activated at the onset of obesity and diverse metabolic diseases. Endocannabinoids mediate their physiological and behavioral effects by activating specific cannabinoid receptors, mainly cannabinoid receptor 1 (CB(1)R). Diabetic nephropathy (DN) is induced by hyperlipidemia, and ren...

journal_title：Journal of cellular physiology

authors： Lim JC,Lim SK,Han HJ,Park SH

更新日期：2010-11-01 00:00:00

abstract：:In areolar "loose" connective tissue, fibroblasts remodel their cytoskeleton within minutes in response to static stretch resulting in increased cell body cross-sectional area that relaxes the tissue to a lower state of resting tension. It remains unknown whether the loosely arranged collagen matrix, characteristic of...

journal_title：Journal of cellular physiology

authors： Abbott RD,Koptiuch C,Iatridis JC,Howe AK,Badger GJ,Langevin HM

更新日期：2013-01-01 00:00:00

abstract：:Arterial smooth muscle cells undergo marked biochemical and morphological changes upon culturing. We have studied the time course of these changes in smooth muscle cells isolated from normal rabbit aortas by enzymic digestion and then maintained in Dulbecco's modified Eagle's medium with or without 10% rabbit serum. S...

journal_title：Journal of cellular physiology

authors： Yau-Young AO,Shio H,Fowler S

更新日期：1981-09-01 00:00:00

abstract：:Human dental pulp stem cells (hDPSCs) show significant potential for exploitation in novel regeneration strategies, although lack of understanding of their responses to bacterial challenge constrains their application. The present study aimed to investigate whether lipopolysaccharide (LPS), the major pathogenic factor...

journal_title：Journal of cellular physiology

authors： He W,Wang Z,Luo Z,Yu Q,Jiang Y,Zhang Y,Zhou Z,Smith AJ,Cooper PR

更新日期：2015-03-01 00:00:00

abstract：:Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT). MAT1A is silenced in hepatocellular carcinoma (HCC), and absence of MAT1A leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to silencing of MAT1A but definitive proof was lac...

journal_title：Journal of cellular physiology

authors： Tomasi ML,Li TW,Li M,Mato JM,Lu SC

更新日期：2012-04-01 00:00:00

abstract：:Fibroblast growth factor (FGF)-21 is a novel regulator of insulin-independent glucose transport in 3T3-L1 adipocytes and has glucose and triglyceride lowering effects in rodent models of diabetes. The precise mechanisms whereby FGF-21 regulates metabolism remain to be determined. Here we describe the early signaling e...

journal_title：Journal of cellular physiology

authors： Moyers JS,Shiyanova TL,Mehrbod F,Dunbar JD,Noblitt TW,Otto KA,Reifel-Miller A,Kharitonenkov A

更新日期：2007-01-01 00:00:00

abstract：:Alpha-2-glycoprotein 1, zinc-binding (AZGP1), known as zinc-alpha-2-glycoprotein (ZAG), is a multifunctional secretory glycoprotein and relevant to cancer metastasis. Little is known regarding the underlying mechanisms of AZGP1 in prostate cancer (PCa). In the present study, we report that AZGP1 is an androgen-respons...

journal_title：Journal of cellular physiology

authors： Cao R,Ke M,Wu Q,Tian Q,Liu L,Dai Z,Lu S,Liu P

更新日期：2019-08-01 00:00:00

abstract：:The myelin basic protein (MBP) gene contains sequences located upstream of its transcription start site which play a key role in glial-specific transcription of the MBP promoter. Earlier analysis of the 320 bp upstream regulatory sequence of MBP has revealed multiple cis-acting regulatory motifs which differentially r...

journal_title：Journal of cellular physiology

authors： Haque NS,Haas S,Knobler RL,Khalili K

更新日期：1995-05-01 00:00:00

abstract：:The non-POU-domain-containing octamer binding protein (NONO; also known as p54nrb) has various nuclear functions ranging from transcription, RNA splicing, DNA synthesis and repair. Although tyrosine phosphorylation has been proposed to account for the multi-functional properties of p54nrb, direct evidence on p54nrb as...

journal_title：Journal of cellular physiology

authors： Lee AR,Hung W,Xie N,Liu L,He L,Dong X

更新日期：2017-04-01 00:00:00

abstract：:Wnt5a, a member of the noncanonical Wnt proteins, is known to play important roles in the development of various organs and in postnatal cell functions. However, little is known about the effects of Wnt5a on human periodontal ligament (PDL) cells. In this study, we examined the localization and potential function of W...

journal_title：Journal of cellular physiology

authors： Hasegawa D,Wada N,Maeda H,Yoshida S,Mitarai H,Tomokiyo A,Monnouchi S,Hamano S,Yuda A,Akamine A

更新日期：2015-11-01 00:00:00